Trp73tm1(cre)Agof
Targeted Allele Detail
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Symbol: |
Trp73tm1(cre)Agof |
Name: |
transformation related protein 73; targeted mutation 1, Andre M Goffinet |
MGI ID: |
MGI:4365581 |
Synonyms: |
DeltaNp73-, DeltaNp73-Cre, DeltaNp73CreiresEGFP |
Gene: |
Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
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Alliance: |
Trp73tm1(cre)Agof page
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Trp73tm1(cre)Agof expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A cre recombinase sequence was targeted to the Trp73 locus in frame at the alternative start codon located in exon 3' (where transcription of the DeltaNp73 isoform is initiated), inactivating the DeltaNp73 isoform and leaving the primary Trp73 transcript (TAp73) unaffected. The cre sequence is followed by an internal ribosomal entry site (IRES) and an EGFP coding sequence. The targeting construct that was used also contains an FRT-flanked Neo cassette and a diphtheria toxin A (DTA) negative selection cassette.
(J:153209)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Trp73
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trp73 Mutation: |
42 strains or lines available
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Original: |
J:153209 Tissir F, et al., DeltaNp73 regulates neuronal survival in vivo. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16871-6 |
All: |
15 reference(s) |
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