About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp73tm1(cre)Agof
targeted mutation 1, Andre M Goffinet
MGI:4365581
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp73tm1(cre)Agof/Trp73tm1(cre)Agof involves: 129S1/Sv * 129X1/SvJ MGI:4365608
cn2
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Trp73tm1(cre)Agof/Trp73+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365609
cn3
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365610
cn4
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365612


Genotype
MGI:4365608
hm1
Allelic
Composition		 Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased neuron apoptosis ( J:153209 )
• at E13.5, apoptotic Cajal-Retzius cells are detected in the cortical marginal zone and cortical hem; in the trigeminal ganglion, apoptosis is drastically increased compared to wild-type controls
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers
abnormal forebrain development ( J:153209 )
• from E12.5 onward, number of Cajal-Retzius cells in marginal zone, thalamic eminence, or choroid plexuses labeling for the deleted Trp73 isoform DeltaNp73 progressively decreases compared to controls, becoming significant after birth; at P0, Reelin-positive cells are reduced by 50%
abnormal choroid plexus morphology ( J:153209 )
• choroid plexus is reduced in size at P0
abnormal hypothalamus morphology ( J:153209 )
• number of GnRH-positive neurons in preoptic area (generated initially in VNO) is dramatically reduced at P0

reproductive system
reduced fertility ( J:153209 )
• both males and females exhibit impaired fertility; this is particularly evident in females which generate only 2 or three litters

respiratory system
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers

craniofacial
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers

cellular
increased neuron apoptosis ( J:153209 )
• at E13.5, apoptotic Cajal-Retzius cells are detected in the cortical marginal zone and cortical hem; in the trigeminal ganglion, apoptosis is drastically increased compared to wild-type controls

growth/size/body
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers




Genotype
MGI:4365609
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Trp73tm1(cre)Agof/Trp73+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced




Genotype
MGI:4365610
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 72% at P0




Genotype
MGI:4365612
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (42 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0
• nearly all CRc in the hippocampal formation are ablated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory