Dab1^tm3.1Cpr
Targeted Allele Detail

Summary

• Symbol: Dab1^tm3.1Cpr
• Name: disabled 1; targeted mutation 3.1, Jonathan A Cooper
• MGI ID: MGI:2388312
• Synonyms: Dab1^p45
• Gene: Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
• Alliance: Dab1^tm3.1Cpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74239
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The floxed neo cassette was removed from Dab1^tm3Cpr via in vivo cre mediated excision. The inserted 271 codon cDNA fragment was left intact. Translation produces a truncated protein (p45) containing 30 unique residues in place of the endogenous 314 carboxy residues. Western blot analysis of homozygous mutant mice showed the exclusive presence of p45 protein, p80 was undetected. (J:74239)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab1 Mutation: 77 strains or lines available

References

• Original: J:74239 Herrick TM, et al., A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development. 2002 Feb 1;129(3):787-96
• All: 3 reference(s)