Dab1^tm4Cpr
Targeted Allele Detail

Summary

• Symbol: Dab1^tm4Cpr
• Name: disabled 1; targeted mutation 1, Jonathan A Cooper
• MGI ID: MGI:3050637
• Synonyms: Dab1^F158V
• Gene: Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
• Alliance: Dab1^tm4Cpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector inserted an F158V mutation as well as a pA-floxed neomycin cassette. Cre expression excised the floxed neo as mice were crossed with a strain expressing Cre in the germ line. Protein levels of mutants were very similar to those of heterozygotes and wild-types. (J:91679)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab1 Mutation: 77 strains or lines available

References

• Original: J:91679 Herrick TM, et al., High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res. 2004 Jul 26;126(2):121-8
• All: 1 reference(s)