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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dab1tm4Cpr
targeted mutation 1, Jonathan A Cooper
MGI:3050637
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dab1tm4Cpr/Dab1tm4Cpr involves: 129/Sv * C57BL/6 MGI:3050784
ht2
 		Dab1tm1Cpr/Dab1tm4Cpr involves: 129/Sv * C57BL/6 MGI:3050789
cx3
 		Dab1tm1Cpr/Dab1tm4Cpr
Relnrl/Reln+ 		involves: 129/Sv * C3HeB/Fe * C57BL/6 MGI:3050790


Genotype
MGI:3050784
hm1
Allelic
Composition		 Dab1tm4Cpr/Dab1tm4Cpr
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm4Cpr mutation (0 available); any Dab1 mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:91679 )
• homozygotes are viable and fertile and no defects are seen in the cortex, hippocampus, cerebellum, or other brain regions




Genotype
MGI:3050789
ht2
Allelic
Composition		 Dab1tm1Cpr/Dab1tm4Cpr
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation (1 available); any Dab1 mutation (77 available)
Dab1tm4Cpr mutation (0 available); any Dab1 mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cortical marginal zone morphology ( J:91679 )
• the marginal zone of the cortex is reduced compared to mice heterozygous for either allele alone
• at E16.5 cortical plate neurons are more superficial than normal




Genotype
MGI:3050790
cx3
Allelic
Composition		 Dab1tm1Cpr/Dab1tm4Cpr
Relnrl/Reln+
Genetic
Background		 involves: 129/Sv * C3HeB/Fe * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation (1 available); any Dab1 mutation (77 available)
Dab1tm4Cpr mutation (0 available); any Dab1 mutation (77 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cortical marginal zone morphology ( J:91679 )
• the marginal zone of the cortex is reduced, similar to compound heterozygous mice wild-type for Reln
abnormal hippocampus morphology ( J:91679 )
• the hippocampus is subtly disorganized in the CA2/3 region compared to mice heterozygous for Dab1tm1Cpr and Relnrl




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory