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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		T
brachyury
MGI:1856184
Summary 31 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		T/T involves: BTBR MGI:3663267
hm2
 		T/T Not Specified MGI:2169509
ht3
 		T/T+ Not Specified MGI:3663264
ht4
 		Tc/T Not Specified MGI:3783797
cx5
 		Sp5tm1Rbe/Sp5tm1Rbe
T/T+ 		involves: 129P2/Ola * C57BL/6J MGI:3029242
cx6
 		T/T+
th7m2/t+
Itpr3tf/Itpr3+ 		involves: BTBR MGI:5465016
cx7
 		Itpr3tf/Itpr3+
T/T+
thr4/t+ 		involves: BTBR MGI:5465159
cx8
 		T/twPas1 involves: BTBR/Nev T * M. m. brevirostris MGI:4821115
cx9
 		T/T+
Tg(T)118.9Bgh/0 		involves: C57BL/6 * CBA MGI:3784873
cx10
 		T/tbtm involves: C57BL/6 * MOL-NIS MGI:4457262
cx11
 		T/twPas2 involves: M. m. brevirostris MGI:4821153
cx12
 		T/twPas3 involves: M. m. domesticus MGI:4821268
cx13
 		T/tw73 involves: M. m. musculus MGI:5288480
cx14
 		T/tbtm MOL-NIS MGI:4819839
cx15
 		T/t4 Not Specified MGI:4461305
cx16
 		T ts6/T+ t+ Not Specified MGI:4839335
cx17
 		T t+/T+ th17 Not Specified MGI:4844309
cx18
 		T t+/T+ th45 Not Specified MGI:4868204
cx19
 		T th20/T+ t+ Not Specified MGI:4868366
cx20
 		T t+/T+ tTu3 Not Specified MGI:5284985
cx21
 		T/T+
th7m/t+ 		Not Specified MGI:5465011
cx22
 		T/twN27 Not Specified MGI:4460903
cx23
 		T/T+
th7m2/t+ 		Not Specified MGI:5465018
cx24
 		T/T+
thr1/t+ 		Not Specified MGI:5465026
cx25
 		T/T+
thr15/t+ 		Not Specified MGI:5465028
cx26
 		T/T+
thr4/t+ 		Not Specified MGI:5465155
cx27
 		T/tks1 Not Specified MGI:4458399
cx28
 		T/T+
tlow2H/t+ 		Not Specified MGI:5465165
cx29
 		T/tw3 Not Specified MGI:5906043
cx30
 		T/t6 Not Specified MGI:3663265
cx31
 		T/tAE5 Not Specified MGI:4461426


Genotype
MGI:3663267
hm1
Allelic
Composition		 T/T
Genetic
Background		 involves: BTBR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart looping ( J:52218 )
• exhibit ventrally displaced ventricular loops and a 50% incidence of inverted heart situs
abnormal heart tube morphology ( J:52218 )
• the early heart tube is bilaterally symmetrical, with a distinct grove on both left and right sides, forming a figure-of-eight outline at E8.5




Genotype
MGI:2169509
hm2
Allelic
Composition		 T/T
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
caudal body truncation ( J:13018 )
• posterior region of the body is greatly reduced at E10
decreased embryo size ( J:11933 , J:13018 )
• structures posterior to the forelimb buds are not formed (J:11933)
abnormal forelimb bud morphology ( J:13018 )
• anterior limb buds are directed dorsad rather than ventrad
absent hindlimb buds ( J:13018 )
• posterior limb buds are absent as the posterior region of the body does not develop
abnormal neural tube morphology ( J:11933 , J:13018 , J:59271 )
• neural tube is slightly irregular at E8.5 and by E9, is markedly irregular in the posterior end; neural tube is more affected in the posterior than anterior end (J:13018)
• exhibit asymmetry of the neural tube in the mid-region at around E9 (J:13018)
• neural tube sends out branches with secondary lumina and often the branch becomes larger than the primary neural tube (J:13018)
• in some embryos, the neural tube lumen is ruptured to the outside and is continuous with the amniotic cavity (J:13018)
• few cases show fusion between the neural tube and the gut in the posterior region (J:13018)
• abnormal folding and kinking of the neural folds at E8 that culminates in ectopic tubular epithelial structures lying ventral to the developing endogenous neural folds (J:59271)
absent notochord ( J:13018 )
• notochord is absent, except for fragments in early stages
abnormal primitive streak formation ( J:11933 )
• backward growth does not occur preventing organization of the posterior axis and emergence of the allantoic placental stalk
abnormal somite development ( J:11933 , J:13018 )
• somites appear normal at early stages but at later stages, they are reduced and by E10, somite tissue is almost absent (J:13018)
abnormal placenta development ( J:11933 )
• results in embryonic death at at E10.75

growth/size/body
abnormal head shape ( J:13018 )
• in a few cases, the head region, particularly the mouth, is malformed
decreased embryo size ( J:11933 , J:13018 )
• structures posterior to the forelimb buds are not formed (J:11933)

cardiovascular system
abnormal dorsal aorta morphology ( J:13018 )
• one of the two dorsal arotae is obliterated by a diverticulum from the neural tube
delayed heart development ( J:13018 )
• heart development is sometimes retarded
abnormal pericardial cavity morphology ( J:13018 )
• commonly, the pericardial cavity is enlarged
hemorrhage ( J:13018 )
• E10 homozygotes contain numerous blood-filled sinuses in the posterior end
hemopericardium ( J:13018 )
• pericardial cavity is often filled with blood at E10

craniofacial
abnormal head shape ( J:13018 )
• in a few cases, the head region, particularly the mouth, is malformed

limbs/digits/tail
abnormal forelimb bud morphology ( J:13018 )
• anterior limb buds are directed dorsad rather than ventrad
absent hindlimb buds ( J:13018 )
• posterior limb buds are absent as the posterior region of the body does not develop

nervous system
abnormal nervous system development ( J:13018 )
• no regular segmental dorsal ganglia are formed in E10 embryos although ganglion tissue is found
abnormal neural tube morphology ( J:11933 , J:13018 , J:59271 )
• neural tube is slightly irregular at E8.5 and by E9, is markedly irregular in the posterior end; neural tube is more affected in the posterior than anterior end (J:13018)
• exhibit asymmetry of the neural tube in the mid-region at around E9 (J:13018)
• neural tube sends out branches with secondary lumina and often the branch becomes larger than the primary neural tube (J:13018)
• in some embryos, the neural tube lumen is ruptured to the outside and is continuous with the amniotic cavity (J:13018)
• few cases show fusion between the neural tube and the gut in the posterior region (J:13018)
• abnormal folding and kinking of the neural folds at E8 that culminates in ectopic tubular epithelial structures lying ventral to the developing endogenous neural folds (J:59271)

integument
abnormal epidermal layer morphology ( J:13018 )
• exhibit transient blistering of the dorsal epithelium, first seen at the time of the formation of the first few somites but is completely gone by the time the embryo has attained the second flexure
bleb ( J:13018 )
• embryos exhibit small paired or unpaired blebs or small vesicles on either side of the mid-line at E8.5-9

homeostasis/metabolism
hemopericardium ( J:13018 )
• pericardial cavity is often filled with blood at E10




Genotype
MGI:3663264
ht3
Allelic
Composition		 T/T+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
decreased ventral ectodermal ridge size ( J:15081 )
• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size
decreased caudal vertebrae number ( J:15081 )
• caudal vertebrae numbers range from 10 to 24, with an average of 21
short tail ( J:13018 , J:15081 )
• seen by E11 (J:13018)
• tail is reduced by about 1/3 in most mutants (J:15081)

embryo
abnormal neural tube morphology ( J:13018 )
• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal
abnormal notochord morphology ( J:13018 , J:15081 )
• contain a notochord, however it can be retained in the roof of the gut or cloaca for varying distances and for a limited period, it may be slow to separate from the overlying neural plate or neural tube, or it may secondarily become incorporated completely into the neural tube or the tail-gut (J:15081)
• the notocord has a central lumen in places (J:15081)
• commonly see branching of the notochord proper; at E10-12.5, branches occur mainly in the region of the cloaca and the proximal parts of the tail (J:15081)
decreased ventral ectodermal ridge size ( J:15081 )
• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size

skeleton
decreased caudal vertebrae number ( J:15081 )
• caudal vertebrae numbers range from 10 to 24, with an average of 21

nervous system
abnormal neural tube morphology ( J:13018 )
• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal




Genotype
MGI:3783797
ht4
Allelic
Composition		 Tc/T
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
Tc mutation (3 available); any T mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:5003 )
• these compound heterozygotes display the same embryonic abnormalities at embryonic day 9 to 10 as T/T homozygotes




Genotype
MGI:3029242
cx5
Allelic
Composition		 Sp5tm1Rbe/Sp5tm1Rbe
T/T+
Genetic
Background		 involves: 129P2/Ola * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp5tm1Rbe mutation (0 available); any Sp5 mutation (15 available)
T mutation (23 available); any T mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
decreased caudal vertebrae number ( J:65743 )
• majority of tails are comprised of fewer than 8 vertebrae

skeleton
decreased caudal vertebrae number ( J:65743 )
• majority of tails are comprised of fewer than 8 vertebrae
abnormal lumbar vertebrae morphology ( J:65743 )
• lumbar vertebrae defect consisting of an imperfect fusion of the two ventral halves of the vertebra, resulting in an abnormal centrum




Genotype
MGI:5465016
cx6
Allelic
Composition		 T/T+
th7m2/t+
Itpr3tf/Itpr3+
Genetic
Background		 involves: BTBR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr3tf mutation (20 available); any Itpr3 mutation (174 available)
T mutation (23 available); any T mutation (60 available)
th7m2 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:34190 )
N
• mice exhibit normal fertility




Genotype
MGI:5465159
cx7
Allelic
Composition		 Itpr3tf/Itpr3+
T/T+
thr4/t+
Genetic
Background		 involves: BTBR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr3tf mutation (20 available); any Itpr3 mutation (174 available)
T mutation (23 available); any T mutation (60 available)
thr4 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:169366 )
• high transmission ratio distortion in favour of the thr4 haplotype from males




Genotype
MGI:4821115
cx8
Allelic
Composition		 T/twPas1
Genetic
Background		 involves: BTBR/Nev T * M. m. brevirostris
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
twPas1 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
absent tail ( J:6461 )
• when males of this genotype are mated to wild-type females the t-haplotype appears among teh offspring more frequently than expected

reproductive system




Genotype
MGI:3784873
cx9
Allelic
Composition		 T/T+
Tg(T)118.9Bgh/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
Tg(T)118.9Bgh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:3956 )
N
• in the presence of T, transgene carriers have normal length tails, indicative of a complete rescue of phenotype




Genotype
MGI:4457262
cx10
Allelic
Composition		 T/tbtm
Genetic
Background		 involves: C57BL/6 * MOL-NIS
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tbtm mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal rostral-caudal body axis extension ( J:21054 )
• attenuated development of the posterior part of the body
abnormal neural tube morphology ( J:21054 )
• generally distorted, duplicated or fused with the mesenchyme
meningomyelocele ( J:21054 )
• presents as a dorsal blood blister in the lumbosacral region
abnormal notochord morphology ( J:21054 )
• E11-12 embryos show abnormalities in the medio-dorsal area
notochord degeneration ( J:21054 )
• seen in E11-12 embryos
split notochord ( J:21054 )
• seen in E11-12 embryos
abnormal tail bud morphology ( J:21054 )
• at E10 a constriction occurs as the tail develops

nervous system
abnormal neural tube morphology ( J:21054 )
• generally distorted, duplicated or fused with the mesenchyme
meningomyelocele ( J:21054 )
• presents as a dorsal blood blister in the lumbosacral region
abnormal spinal cord morphology ( J:21054 )
• posterior to the lumbosacral level the cord is severely distorted or duplicated and devoid of vertebrae

limbs/digits/tail
abnormal tail bud morphology ( J:21054 )
• at E10 a constriction occurs as the tail develops
absent tail ( J:21054 )
• mice with this genotype lack a tail at birth and have blood listers or red scars on the dorsal skin at the middle of the lumbosacral region

skeleton
meningomyelocele ( J:21054 )
• presents as a dorsal blood blister in the lumbosacral region
abnormal thoracic vertebrae morphology ( J:21054 )
• rib fusions, lack of vertebral bodies and arches
abnormal lumbar vertebrae morphology ( J:21054 )
• rib fusions, lack of vertebral bodies and arches
absent vertebral arch ( J:21054 )
• an abnormality of thoracic and lumbar vertebrae
absent vertebral body ( J:21054 )
• an abnormality of thoracic and lumbar vertebrae




Genotype
MGI:4821153
cx11
Allelic
Composition		 T/twPas2
Genetic
Background		 involves: M. m. brevirostris
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
twPas2 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail

reproductive system
transmission ratio distortion ( J:6461 )
• in a test cross with a wild-type female mouse the t-haplotype is seen in offspring less frequently than expected




Genotype
MGI:4821268
cx12
Allelic
Composition		 T/twPas3
Genetic
Background		 involves: M. m. domesticus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
twPas3 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail

reproductive system
transmission ratio distortion ( J:6461 )
• when males of this genotype are mated to wild-type females the t haplotype occurs among the offspring more frequently than expected




Genotype
MGI:5288480
cx13
Allelic
Composition		 T/tw73
Genetic
Background		 involves: M. m. musculus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tw73 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:175677 )
• males of this genotype transmit tw73 to 88.6 per cent of offspring

limbs/digits/tail
absent tail ( J:175677 )
• all mice of this genotype are tailless




Genotype
MGI:4819839
cx14
Allelic
Composition		 T/tbtm
Genetic
Background		 MOL-NIS
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tbtm mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:14919 )
• all mice are dead by 60 days of age; the few longest-lived have hind-limb paralysis
perinatal lethality, incomplete penetrance ( J:14919 )
• most die shortly after birth and have a blood blister in the lumbosacral area and hind-limb paralysis

limbs/digits/tail
absent tail ( J:14919 )
• all mice of this genotype are tailless

reproductive system
reproductive system phenotype ( J:14919 )
N
• mice are fertile and there is no evidence of transmission ratio distortion




Genotype
MGI:4461305
cx15
Allelic
Composition		 T/t4
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
t4 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail

reproductive system
transmission ratio distortion ( J:36683 )
• T-bearing gametes are in excess although not uniformly the case from male to male




Genotype
MGI:4839335
cx16
Allelic
Composition		 T ts6/T+ t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
ts6 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:6478 )
• 85% of offspring produced from 3 matings of Tts6 males to wild-type females are short-tailed; 15% are normal-tailed




Genotype
MGI:4844309
cx17
Allelic
Composition		 T t+/T+ th17
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
th17 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:5889 )
• mice with this genotype have short tails; they are not tailless as are mice heterozygous for brachyury and carrying any of the majority of other t haplotypes
• there is no transmission ratio distortion as might be expected from males of this genotype




Genotype
MGI:4868204
cx18
Allelic
Composition		 T t+/T+ th45
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
th45 mutation (1 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:4868366
cx19
Allelic
Composition		 T th20/T+ t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
th20 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:5284985
cx20
Allelic
Composition		 T t+/T+ tTu3
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tTu3 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:6700 )
N
• the tail length is normal although a mouse inheriting a t haplotype with T is frequently tailless




Genotype
MGI:5465011
cx21
Allelic
Composition		 T/T+
th7m/t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
th7m mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:4460903
cx22
Allelic
Composition		 T/twN27
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
twN27 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
absent tail ( J:32745 )
• indicative of the presence of a t haplotype




Genotype
MGI:5465018
cx23
Allelic
Composition		 T/T+
th7m2/t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
th7m2 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:5465026
cx24
Allelic
Composition		 T/T+
thr1/t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
thr1 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:5465028
cx25
Allelic
Composition		 T/T+
thr15/t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
thr15 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:5465155
cx26
Allelic
Composition		 T/T+
thr4/t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
thr4 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:4458399
cx27
Allelic
Composition		 T/tks1
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tks1 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail

reproductive system
transmission ratio distortion ( J:8922 )
• only 37% of sperm from males of this genotype carry the tks1 haplotype




Genotype
MGI:5465165
cx28
Allelic
Composition		 T/T+
tlow2H/t+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tlow2H mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:183153 )
N
• no effect on tail length




Genotype
MGI:5906043
cx29
Allelic
Composition		 T/tw3
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tw3 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:3663265
cx30
Allelic
Composition		 T/t6
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
t6 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
decreased ventral ectodermal ridge size ( J:15081 )
• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size

embryo
abnormal notochord morphology ( J:15081 )
• the notochord is increased in bulk not only in the distal growth zone (as in T heterozygotes) but in the whole tail, in the cloacal region and even more anteriorly in the lumbar region and has large lumina
• the notochord is present throughout the length of the tail, however it becomes incorporated into the neural tube throughout the tail and often the cloacal region
decreased ventral ectodermal ridge size ( J:15081 )
• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size




Genotype
MGI:4461426
cx31
Allelic
Composition		 T/tAE5
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (23 available); any T mutation (60 available)
tAE5 mutation (0 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory