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Targeted Allele Detail
Symbol: Sp5tm1Rbe
Name: trans-acting transcription factor 5; targeted mutation 1, Rosa Beddington
MGI ID: MGI:1933409
Synonyms: Sp5lacZ
Gene: Sp5  Location: Chr2:70305267-70308070 bp, + strand  Genetic Position: Chr2, 41.49 cM
Alliance: Sp5tm1Rbe page
Germline Transmission:  Earliest citation of germline transmission: J:65743
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn IRES-LacZ-floxed-MC1-neomycin resistance cassette replaced much of the open reading frame. The authors predict that the targeted allele would encode a bicistronic message under control of the endogenous promoter that expresses both a truncated N-terminal SP5 protein and beta-galactosidase. (J:65743)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp5 Mutation:  15 strains or lines available
Original:  J:65743 Harrison SM, et al., Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury. Dev Biol. 2000 Nov 15;227(2):358-72
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory