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Insr Gene Detail
Summary
  • Symbol
    Insr
  • Name
    insulin receptor
  • Synonyms
    4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96575
    NCBI Gene: 16337
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3200922-3329649 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.82 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2328 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96575
 protein coding gene Chr8:3172061-3329649 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033299
 protein coding gene Chr8:40653-173808 (-)
A/J MGP_AJ_G0033282
 protein coding gene Chr8:54725-184202 (-)
AKR/J MGP_AKRJ_G0033213
 protein coding gene Chr8:65881-199385 (-)
BALB/cJ MGP_BALBcJ_G0033282
 protein coding gene Chr8:88993-218917 (-)
C3H/HeJ MGP_C3HHeJ_G0032996
 protein coding gene Chr8:69500-202041 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033792
 protein coding gene Chr8:55684-192168 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030765
 protein coding gene Chr8:14725-147101 (-)
CAST/EiJ MGP_CASTEiJ_G0032319
 protein coding gene Chr8:58181-200321 (-)
CBA/J MGP_CBAJ_G0032969
 protein coding gene Chr8:54874-194904 (-)
DBA/2J MGP_DBA2J_G0033123
 protein coding gene Chr8:28083-157567 (-)
FVB/NJ MGP_FVBNJ_G0033070
 protein coding gene Chr8:72888-202090 (-)
LP/J MGP_LPJ_G0033215
 protein coding gene Chr8:46978-181996 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033105
 protein coding gene Chr8:71899-211810 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033810
 protein coding gene Chr8:35899-171728 (-)
PWK/PhJ MGP_PWKPhJ_G0032029
 protein coding gene Chr8:44522-177598 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031873
 protein coding gene Chr8:44062-175441 (-)
WSB/EiJ MGP_WSBEiJ_G0032432
 protein coding gene Chr8:36032-175685 (-)



Homology
more
  • Human Ortholog
    INSR, insulin receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INSR, insulin receptor
  • Synonyms
    CD220, HHF5
  • Links
    NCBI Gene ID: 3643
    UniProt: P06213

  • Chr Location
    19p13.2; chr19:7112255-7294414 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Insr mouse models; 7 with human INSR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
 View 2 "NOT" models
IDs
IDs
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 9 alleles in 20 genetic backgrounds
    70 phenotypes from multigenic genotypes
    378 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutants grow slowly and die by 7 days of age with ketoacidosis, high serum insulin and triglycerides, low glycogen stores and fatty livers. Tissue specific knockouts show milder lipid metabolism anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    214
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    53
  • cDNA Data
    75
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16337 NCBI Gene Model | MGI Sequence Detail 128728 C57BL/6J ±  kb
    transcript NM_001330056 RefSeq | MGI Sequence Detail 9391 ZRU/MplStud  
    polypeptide P15208 UniProt | EBI | MGI Sequence Detail 1372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      Genomic 5
      cDNA 76
      Primer pair 12
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11417, MGI:2442502, MGI:2443766
    References
    more
    • Summaries
      All 558
      Developmental Gene Expression 46
      Diseases 5
      Gene Ontology 42
      Phenotypes 378
    • Earliest
      J:9626 Wang LM, et al., Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors. Genomics. 1988 Aug;3(2):172-6
    • Latest
      J:374224 Rajala R, et al., Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes. Arterioscler Thromb Vasc Biol. 2025 Sep;45(9):1648-1663
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory