Gene Expression Literature Summary

• Symbol: Insr
• Name: insulin receptor
• ID: MGI:96575

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3.5	E4	E4.5	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)													1	2				1						1		1
In situ RNA (section)												1	2	1		2		3	2					1		2
Western blot													2	1				1	1		1		1	4	1	7
RT-PCR	2	2	1	2	2	1	1	1		2	3	3	6	5	1	6		4	7	3		2	1	7	2	16
cDNA clones									1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Insr  insulin receptor   (Synonyms: 4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B)
Results	Reference
2	J:305792 Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U, Lickert H, Inceptor counteracts insulin signalling in beta-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331
1*	J:130984 Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I, A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):270-5
1	J:203449 Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB, The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem. 2013 Aug 23;288(34):24528-39
2	J:184234 Chirivella L, Cano-Jaimez M, Perez-Sanchez F, Herraez L, Carretero J, Farinas I, Burks DJ, Kirstein M, IRS2 signalling is required for the development of a subset of sensory spinal neurons. Eur J Neurosci. 2012 Feb;35(3):341-52
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:106827 Duvillie B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ, Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin. Endocrinology. 2002 Apr;143(4):1530-7
2*	J:175639 Erickson RP, Strnatka D, Insulin receptor-related (Irr) is expressed in pre-implantation embryos: A possible relationship to 'growth factor Y' and sex determination. Mol Reprod Dev. 2011 Aug;78(8):552
1	J:227002 Ferron SR, Radford EJ, Domingo-Muelas A, Kleine I, Ramme A, Gray D, Sandovici I, Constancia M, Ward A, Menheniott TR, Ferguson-Smith AC, Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis. Nat Commun. 2015;6:8265
2	J:326089 Ghnaimawi S, Zhang S, Baum JI, Huang Y, The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
1*	J:314325 Glendining KA, Higgins MBA, Fisher LC, Jasoni CL, Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain Behav Immun. 2020 Aug;88:151-160
1	J:315113 Hafner R, Bohnenpoll T, Rudat C, Schultheiss TM, Kispert A, Fgfr2 is required for the expansion of the early adrenocortical primordium. Mol Cell Endocrinol. 2015 Sep 15;413:168-77
2	J:284494 Hancock ML, Meyer RC, Mistry M, Khetani RS, Wagschal A, Shin T, Ho Sui SJ, Naar AM, Flanagan JG, Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019 Apr 18;177(3):722-736.e22
2	J:228647 Heilig J, Paulsson M, Zaucke F, Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification. Bone. 2016 Feb;83:48-57
1	J:326543 Jiang A, Guo H, Jiang X, Tao J, Wu W, Liu H, G6PD Deficiency Is Crucial for Insulin Signaling Activation in Skeletal Muscle. Int J Mol Sci. 2022 Jul 4;23(13)
1	J:277295 Jin J, Ravindran P, Di Meo D, Puschel AW, Igf1R/InsR function is required for axon extension and corpus callosum formation. PLoS One. 2019;14(7):e0219362
4	J:326523 Kheirollahi V, Khadim A, Kiliaris G, Korfei M, Barroso MM, Alexopoulos I, Vazquez-Armendariz AI, Wygrecka M, Ruppert C, Guenther A, Seeger W, Herold S, El Agha E, Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis. Cells. 2022 Jun 20;11(12)
2	J:19199 Larsson-Blomberg L, Dzierzak E, Isolation of tyrosine kinase related genes expressed in the early hematopoietic system. FEBS Lett. 1994 Jul 11;348(2):119-25
10	J:171220 Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Bruning JC, Pashmforoush M, Sucov HM, IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 2011 May;138(9):1795-805
4*	J:158405 Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF, Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 2010 Feb;151(2):741-7
2	J:192831 Lin JC, Yan YT, Hsieh WK, Peng PJ, Su CH, Tarn WY, RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
3*	J:292617 Lin YC, Lu YH, Lee YC, Hung CS, Lin JC, Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism. Biochim Biophys Acta Gene Regul Mech. 2020 Jul 3;1863(9):194601
3	J:241923 Lopez IP, Pineiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG, Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PLoS One. 2016;11(11):e0166388
2	J:333829 Lopez-Tello J, Sferruzzi-Perri AN, Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Front Endocrinol (Lausanne). 2023;14:1116770
8	J:199085 Martinez-Campos E, Hernandez-Sanmiguel E, Lopez-Sanchez C, De Pablo F, Hernandez-Sanchez C, Alternative splicing variants of proinsulin mRNA and the effects of excess proinsulin on cardiac morphogenesis. FEBS Lett. 2013 Jul 11;587(14):2272-7
1	J:203690 Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R, Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803
1	J:154998 Mascarenhas MI, Parker A, Dzierzak E, Ottersbach K, Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling. Blood. 2009 Nov 19;114(21):4645-53
3*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
4	J:321229 Murakami-Kawaguchi S, Takasawa S, Onogawa T, Nata K, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Yamauchi A, Ota H, Takeda M, Kato M, Okamoto H, Expression of Ins1 and Ins2 genes in mouse fetal liver. Cell Tissue Res. 2014 Feb;355(2):303-14
4	J:86618 Nef S, Verma-Kurvari S, Merenmies J, Vassalli JD, Efstratiadis A, Accili D, Parada LF, Testis determination requires insulin receptor family function in mice. Nature. 2003 Nov 20;426(6964):291-5
1	J:123298 Nguyen TT, Sheppard AM, Kaye PL, Noakes PG, IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells. Reproduction. 2007 Jul;134(1):41-9
3	J:174705 Novitskaya T, Baserga M, de Caestecker MP, Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice. Endocrinology. 2011 Jun;152(6):2503-16
1	J:211117 Pais RS, Moreno-Barriuso N, Hernandez-Porras I, Lopez IP, De Las Rivas J, Pichel JG, Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation. PLoS One. 2013;8(12):e83028
2	J:197599 Pitetti JL, Calvel P, Romero Y, Conne B, Truong V, Papaioannou MD, Schaad O, Docquier M, Herrera PL, Wilhelm D, Nef S, Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
1	J:326026 Prokopuk L, Jarred EG, Blucher RO, McLaughlin EA, Stringer JM, Western PS, An essential role for Polycomb Repressive Complex 2 in the mouse ovary. Reproduction. 2022 Feb 17;163(3):167-182
4*	J:35225 Rappolee DA, Sturm KS, Behrendtsen O, Schultz GA, Pedersen RA, Werb Z, Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Genes Dev. 1992 Jun;6(6):939-52
2	J:305574 Shen H, Gan P, Wang K, Darehzereshki A, Wang K, Kumar SR, Lien CL, Patterson M, Tao G, Sucov HM, Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling. Elife. 2020 Mar 13;9:e53071
1	J:235082 Shimazu J, Wei J, Karsenty G, Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148. Cell Rep. 2016 Apr 5;15(1):27-35
6	J:67067 Stojanov T, O'Neill C, In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. Biol Reprod. 2001 Feb;64(2):696-705
5*	J:10840 Telford NA, Hogan A, Franz CR, Schultz GA, Expression of genes for insulin and insulin-like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells. Mol Reprod Dev. 1990 Oct;27(2):81-92
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:138822 Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR, New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008 Aug 21;454(7207):1000-4
3	J:91730 Verma-Kurvari S, Parada LF, Identification of tyrosine kinases expressed in the male mouse gubernaculum during development. Dev Dyn. 2004 Aug;230(4):660-5
9*	J:273626 Wang K, Shen H, Gan P, Cavallero S, Kumar SR, Lien CL, Sucov HM, Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development. BMC Dev Biol. 2019 Mar 25;19(1):5
1*	J:327184 Xiao Z, Liu S, Li Z, Cui J, Wang H, Wang Z, Ren Q, Xia L, Wang Z, Li Y, The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine. Front Cell Dev Biol. 2022;10:882994
3	J:121631 Xie L, Chen H, Overbeek PA, Reneker LW, Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens. Mol Vis. 2007;13:397-407
1	J:102264 Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE, Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res. 2003 Mar;53(3):411-8