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H2-Eb1 Gene Detail
Summary
  • Symbol
    H2-Eb1
  • Name
    histocompatibility 2, class II antigen E beta
  • Synonyms
    H-2Eb, Ia-4, Ia4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95901
    NCBI Gene: 14969
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:34524841-34535648 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    7
  • RFLP
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95901
 protein coding gene Chr17:34524841-34535648 (+)
129S1/SvImJ ENSMUSG00200047267
 protein coding gene Chr17:30227962-30238774 (+)
A/J ENSMUSG00195033299
 protein coding gene Chr17:31094190-31105036 (+)
AKR/J ENSMUSG00220047321
 protein coding gene Chr17:30121823-30132673 (+)
BALB/cJ ENSMUSG00180031138
 protein coding gene Chr17:30478291-30488999 (+)
C3H/HeJ ENSMUSG00175053174
 protein coding gene Chr17:30007973-30018827 (+)
C57BL/6NJ ENSMUSG00215052246
 protein coding gene Chr17:30068143-30078949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021454
 protein coding gene Chr17:31114512-31124399 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210043533
 protein coding gene Chr17:29830086-29840934 (+)
DBA/2J ENSMUSG00185053078
 protein coding gene Chr17:32497570-32508278 (+)
FVB/NJ ENSMUSG00205027396
 protein coding gene Chr17:30344476-30355251 (+)
JF1/MsJ ENSUMUG00000043056
 protein coding gene Chr17:31764913-31775679 (+)
LP/J ENSMUSG00230054074
 protein coding gene Chr17:33626283-33637090 (+)
NOD/ShiLtJ ENSMUSG00190051695
 protein coding gene Chr17:29975840-29986600 (+)
NZO/HlLtJ ENSMUSG00225054299
 protein coding gene Chr17:35659999-35670507 (+)
PWK/PhJ ENSLUMG00010046341
 protein coding gene Chr17:29613316-29624105 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005047430
 protein coding gene Chr17:30681377-30692161 (+)



Homology
more
  • Human Ortholog
    HLA-DRB1, major histocompatibility complex, class II, DR beta 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DRB1, major histocompatibility complex, class II, DR beta 1
  • Synonyms
    DRB1, HLA-DR1B, HLA-DRB, SS1
  • Links
    NCBI Gene ID: 3123
    UniProt: P01911

  • Chr Location
    6p21.32; chr6:32577902-32589848 (-)  GRCh38
  • Human Ortholog
    HLA-DRB3, major histocompatibility complex, class II, DR beta 3
  • Synonyms
    DRB3, HLA-DR3B, HLA DRB3, HLA-DRB3*
  • Links
    NCBI Gene ID: 3125
    UniProt: P79483

  • Chr Location
    6p21.3
  • Human Ortholog
    HLA-DRB4, major histocompatibility complex, class II, DR beta 4
  • Synonyms
    DR4, DRB4, HLA-DR4B, HLA-DRB, HLA-DRB4*
  • Links
    NCBI Gene ID: 3126
    UniProt: P13762

  • Chr Location
    6p21.3
  • Human Ortholog
    HLA-DRB5, major histocompatibility complex, class II, DR beta 5
  • Synonyms
    DRB5, HLA-DRB5*
  • Links
    NCBI Gene ID: 3127
    UniProt: Q30154

  • Chr Location
    6p21.32; chr6:32517345-32530369 (-)  GRCh38
Human Diseases
more
  • Diseases
    94 with human HLA-DRB1,HLA-DRB3,HLA-DRB4,HLA-DRB5 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    285 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    151
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14969 NCBI Gene Model | MGI Sequence Detail 10808 C57BL/6J ±  kb
    transcript NM_010382 RefSeq | MGI Sequence Detail 1669 ZRU/MplStud  
    polypeptide P04230 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 200
      Genomic 37
      cDNA 155
      Primer pair 6
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10384, MGD-MRK-10497, MGD-MRK-11047, MGD-MRK-11052
    References
    more
    • Summaries
      All 365
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 285
    • Earliest
      J:5682 Murphy DB, et al., A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med. 1976 Sep 1;144(3):699-712
    • Latest
      J:391774 Pineda JE, et al., Antigen presentation requirements for effective cDC1-based cancer immunotherapy. J Immunol. 2026 Aug 4;215(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory