H2-Eb1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H2-Eb1
histocompatibility 2, class II antigen E beta
MGI:95901

15 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB50101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas 129S7/SvEvBrd * C57BL/6	brain inflammation	J:189816
H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB50101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas 129S7/SvEvBrd * C57BL/6	brain inflammation	J:189816
H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB50101)hiKito/0 involves: 129S2/SvPas C57BL/6	normal nervous system phenotype	J:189816
H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB50101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas C57BL/6	abnormal axon morphology	J:189816
	abnormal cytokine secretion	J:189816
	abnormal motor capabilities/coordination/movement	J:189816
	axon degeneration	J:189816
	brain inflammation	J:189816
	CNS inflammation	J:189816
	increased CD4-positive, alpha-beta T cell number	J:189816
	increased inflammatory response	J:189816
	increased interferon-gamma secretion	J:189816
	increased interleukin-17 secretion	J:189816
	increased susceptibility to experimental autoimmune encephalomyelitis	J:189816
	increased T-helper 1 cell number	J:189816
	increased T-helper 17 cell number	J:189816
	neuron degeneration	J:189816
H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB50101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas C57BL/6	brain inflammation	J:189816
	increased susceptibility to experimental autoimmune encephalomyelitis	J:189816

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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