Ace MGI Mouse Gene Detail - MGI:87874 - angiotensin I converting enzyme

Symbol

Ace
Name

angiotensin I converting enzyme
Synonyms

CD143

Feature Type

protein coding gene
IDs

MGI:87874
NCBI Gene: 11421
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:105858774-105880790 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.84 cM
Mapping Data

3 experiments

SNPs within 2kb

538 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87874	protein coding gene	Chr11:105858771-105880790 (+)
129S1/SvImJ	ENSMUSG00200031442	protein coding gene	Chr11:103171282-103193303 (+)
A/J	ENSMUSG00195018337	protein coding gene	Chr11:102865743-102887794 (+)
AKR/J	ENSMUSG00220030986	protein coding gene	Chr11:103083373-103105405 (+)
BALB/cJ	ENSMUSG00180016823	protein coding gene	Chr11:103192634-103214665 (+)
C3H/HeJ	ENSMUSG00175011944	protein coding gene	Chr11:103141753-103163779 (+)
C57BL/6NJ	ENSMUSG00215006663	protein coding gene	Chr11:102704337-102726361 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017305	protein coding gene	Chr11:101880015-101901439 (+)
CAST/EiJ	ENSTCUG00005034460	protein coding gene	Chr11:102613456-102635497 (+)
CBA/J	ENSMUSG00210013609	protein coding gene	Chr11:102850680-102872696 (+)
DBA/2J	ENSMUSG00185018581	protein coding gene	Chr11:103191573-103213600 (+)
FVB/NJ	ENSMUSG00205034132	protein coding gene	Chr11:102997029-103019053 (+)
JF1/MsJ	ENSUMUG00000019491	protein coding gene	Chr11:103452481-103475091 (+)
LP/J	ENSMUSG00230031492	protein coding gene	Chr11:104243751-104265776 (+)
NOD/ShiLtJ	ENSMUSG00190019246	protein coding gene	Chr11:103190046-103212059 (+)
NZO/HlLtJ	ENSMUSG00225052085	protein coding gene	Chr11:106279745-106301779 (+)
PWK/PhJ	ENSLUMG00010016106	protein coding gene	Chr11:102975579-102998216 (+)
SPRET/EiJ	ENSMSPG00010035148	protein coding gene	Chr11:103492552-103514907 (+)
WSB/EiJ	ENSIUOG00005017522	protein coding gene	Chr11:102976025-102998060 (+)

Human Ortholog

ACE, angiotensin I converting enzyme

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACE, angiotensin I converting enzyme
Synonyms

ACE1, CD143, DCP, DCP1
Links

HGNC:2707

NCBI Gene ID: 1636

UniProt: P12821
Chr Location

17q23.3; chr17:63477058-63498380 (+) GRCh38

MGI Vertebrate Homology

Ace stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACE
Gene Tree

Ace

Diseases

48 with human ACE associations

				Human Disease	Mouse Models
				alcohol-associated liver disease IDs alcohol-associated liver disease DOID:0070658 ICD10CM:K70 ICD9CM:571.3 MESH:D008108 NCI:C34783 UMLS_CUI:C0023896
				allergic disease IDs allergic disease DOID:1205 ICD10CM:T78.40 MESH:D006967 NCI:C3114 UMLS_CUI:C0020517
				anemia IDs anemia DOID:2355 EFO:0004272 ICD10CM:D64.9 ICD9CM:285.9 MESH:D000740 NCI:C2869 UMLS_CUI:C0002871
				ankylosing spondylitis IDs ankylosing spondylitis DOID:7147 EFO:0003898 ICD10CM:M45 ICD9CM:720.0 MESH:D013167 NCI:C84564 OMIM:PS106300 ORDO:825 UMLS_CUI:C0038013
				aspiration pneumonia IDs aspiration pneumonia DOID:0050152 ICD10CM:J69.0 MESH:D011015 UMLS_CUI:C0032290
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				atrial fibrillation IDs atrial fibrillation DOID:0060224 ICD9CM:427.31 MESH:D001281 NCI:C50466 UMLS_CUI:C0004238
				Behcet's disease IDs Behcet's disease DOID:13241 EFO:0003780 ICD10CM:M35.2 ICD9CM:136.1 ICD9CM_2006:136.1 MESH:D001528 NCI:C34416 OMIM:109650 UMLS_CUI:C0004943
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				Coronavirus infectious disease IDs Coronavirus infectious disease DOID:0080599
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670
				diabetic angiopathy IDs diabetic angiopathy DOID:11713 MESH:D003925 NCI:C35610 UMLS_CUI:C0011871 UMLS_CUI:C0011875
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				diastolic heart failure IDs diastolic heart failure DOID:9775 ICD10CM:I50.30 ICD9CM:428.3 ICD9CM:428.30 MESH:D054144 NCI:C196137 UMLS_CUI:C1135196
				end stage renal disease IDs end stage renal disease DOID:783
				Fabry disease IDs Fabry disease DOID:14499 ICD10CM:E75.21 MESH:D000795 NCI:C84701 OMIM:301500 UMLS_CUI:C0002986
				familial Mediterranean fever IDs familial Mediterranean fever DOID:2987 ICD10CM:M04.1 ICD9CM:277.31 MESH:D010505 NCI:C84707 OMIM:134610 OMIM:249100 ORDO:342 UMLS_CUI:C0031069
				gallbladder adenocarcinoma IDs gallbladder adenocarcinoma DOID:3500 NCI:C9166 UMLS_CUI:C0279651
				heart valve disease IDs heart valve disease DOID:4079 DOID:989 MESH:D006349 MESH:D016127 NCI:C45525 UMLS_CUI:C0018824 UMLS_CUI:C0079485
				hepatitis A IDs hepatitis A DOID:12549 DOID:12547 MESH:D006506 NCI:C3096 UMLS_CUI:C0019159
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661
				IgA vasculitis IDs IgA vasculitis DOID:11123 ICD10CM:D69.0 ICD9CM_2006:287.0 ICD9CM:287.0 MESH:D011695 NCI:C34963 ORDO:761 UMLS_CUI:C0034152
				leukemia IDs leukemia DOID:1240 DOID:9145 ICD10CM:C95.90 ICD9CM:208 ICD9CM:208.9 MESH:D007938 NCI:C3161 UMLS_CUI:C0023418
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 NCI:C194105 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				mitral valve disease IDs mitral valve disease DOID:61 DOID:11505 DOID:58 DOID:59 ICD10CM:I05 ICD10CM:I05.1 ICD9CM_2006:394 ICD9CM:394 ICD9CM:394.1 ICD9CM:424.0 NCI:C197955 NCI:C197957 NCI:C78446 UMLS_CUI:C0026265 UMLS_CUI:C0155563 UMLS_CUI:C0264765
				mitral valve prolapse IDs mitral valve prolapse DOID:988 MESH:D008945 NCI:C50655 OMIM:157700 OMIM:607829 OMIM:610840 UMLS_CUI:C0026267
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				nephritis IDs nephritis DOID:10952 ICD10CM:N08 MESH:D009393 NCI:C26833 UMLS_CUI:C0027697
				non-arteritic anterior ischemic optic neuropathy IDs non-arteritic anterior ischemic optic neuropathy DOID:0050864
				obstructive sleep apnea IDs obstructive sleep apnea DOID:0050848 ICD10CM:G47.33 ICD9CM:327.23 ICD9CM:780.57 MESH:D020181 NCI:C116337 OMIM:107650 UMLS_CUI:C0520679
				pneumonia IDs pneumonia DOID:552 DOID:10509 DOID:11742 DOID:5871 MESH:D011014 NCI:C3333 UMLS_CUI:C0032285
				polycythemia IDs polycythemia DOID:8432 ICD10CM:D75.1 MESH:D011086 NCI:C26863 UMLS_CUI:C0032461
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 ORDO:275555 UMLS_CUI:C0032914
				proteinuria IDs proteinuria DOID:576 ICD10CM:R80 ICD9CM:791.0 MESH:D011507 NCI:C38012 UMLS_CUI:C0033687
				sarcoidosis IDs sarcoidosis DOID:11335 ICD10CM:D86 ICD9CM:135 MESH:D012507 NCI:C34995 ORDO:797 UMLS_CUI:C0036202
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C194067 NCI:C194069 NCI:C194070 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423
				stroke IDs stroke DOID:0051061
				subacute sclerosing panencephalitis IDs subacute sclerosing panencephalitis DOID:8970 ICD10CM:A81.1 ICD9CM:046.2 MESH:D013344 NCI:C85171 OMIM:260470 ORDO:2806 UMLS_CUI:C0038522
				toxic shock syndrome IDs toxic shock syndrome DOID:14115 ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 UMLS_CUI:C0600327
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

78 phenotypes from 12 alleles in 11 genetic backgrounds
34 phenotypes from multigenic genotypes
93 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

6
Targeted

18
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.

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All GO Annotations

151
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

911
Tissues

152
cDNA Data

25
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ACE

Xenbase ace

ZFIN ace

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All Sequences

60
RefSeq

6
UniProt

8
CCDS

CCDS25543.1, CCDS25544.1

Ensembl

ENSMUSG00000020681 (Evidence)
NCBI Gene

11421

			Length	Strain/Species	Flank
genomic	11421	NCBI Gene Model \| MGI Sequence Detail	22017	C57BL/6J	± kb
transcript	NM_001281819	RefSeq \| MGI Sequence Detail	5088	ZRU/MplStud
polypeptide	P09470	UniProt \| EBI \| MGI Sequence Detail	1312	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000001322 angiotensin-converting enzyme

(term hierarchy)
EC

3.4.-.-, 3.4.15.1
InterPro Domains

IPR001548 Peptidase M2, peptidyl-dipeptidase A
GlyGen

P09470 15 sites, 16 N-linked glycans (8 sites), 1 O-linked glycan (1 site)

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All nucleic 36

Genomic 6

cDNA 26

Primer pair 3

Other 1

Antibodies 2

Microarray probesets 5

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MGD-MRK-1032, MGI:2144508

Summaries

All 196

Developmental Gene Expression 23

Gene Ontology 27

Phenotypes 93
Earliest

J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
Latest

J:374183 Garcia-Gomez I, et al., Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture. Sci Adv. 2025 Oct 31;11(44):eadz3944

TSS for Ace:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105461	Chr11:105858468-105858488 (+)	-296 bp
Tssr105462	Chr11:105858740-105858753 (+)	-27 bp
Tssr105463	Chr11:105858764-105858782 (+)	-1 bp
Tssr105464	Chr11:105859341-105859349 (+)	571 bp
Tssr105465	Chr11:105860511-105860530 (+)	1,747 bp
Tssr105466	Chr11:105865465-105865484 (+)	6,701 bp
Tssr105467	Chr11:105865488-105865507 (+)	6,724 bp
Tssr105468	Chr11:105866007-105866021 (+)	7,240 bp
Tssr105469	Chr11:105866030-105866041 (+)	7,262 bp
Tssr3701	Chr11:105866046-105866053 (+)	7,276 bp
Tssr105470	Chr11:105876563-105876577 (+)	17,796 bp
Tssr105471	Chr11:105876580-105876604 (+)	17,818 bp
Tssr3702	Chr11:105876614-105876618 (+)	17,842 bp
Tssr105472	Chr11:105880073-105880082 (+)	21,304 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24