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Ppfia1 Gene Detail
Summary
  • Symbol
    Ppfia1
  • Name
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
  • Synonyms
    C030014K08Rik, liprin, Liprin-alpha1, Liprin-alpha1a, Liprin-alpha1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924750
    NCBI Gene: 233977
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:144030495-144107466 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1306 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924750
 protein coding gene Chr7:144030492-144107497 (-)
129S1/SvImJ ENSMUSG00200042043
 protein coding gene Chr7:130597681-130670915 (-)
A/J ENSMUSG00195001677
 protein coding gene Chr7:135081092-135154351 (-)
AKR/J ENSMUSG00220028759
 protein coding gene Chr7:128558055-128631557 (-)
BALB/cJ ENSMUSG00180035243
 protein coding gene Chr7:131770916-131844415 (-)
C3H/HeJ ENSMUSG00175003973
 protein coding gene Chr7:132502167-132575421 (-)
C57BL/6NJ ENSMUSG00215042180
 protein coding gene Chr7:131768097-131841610 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030754
 protein coding gene Chr7:146633381-146721193 (-)
CAST/EiJ ENSTCUG00005002767
 protein coding gene Chr7:135090844-135164187 (-)
CBA/J ENSMUSG00210003734
 protein coding gene Chr7:132259653-132332915 (-)
DBA/2J ENSMUSG00185014025
 protein coding gene Chr7:136538412-136611673 (-)
FVB/NJ ENSMUSG00205001918
 protein coding gene Chr7:132166443-132239958 (-)
JF1/MsJ ENSUMUG00000001716
 protein coding gene Chr7:141564685-141638162 (-)
LP/J ENSMUSG00230006376
 protein coding gene Chr7:142700118-142773348 (-)
NOD/ShiLtJ ENSMUSG00190003824
 protein coding gene Chr7:132367065-132440576 (-)
NZO/HlLtJ ENSMUSG00225047930
 protein coding gene Chr7:140910369-140983879 (-)
PWK/PhJ ENSLUMG00010036121
 protein coding gene Chr7:130734147-130807680 (-)
SPRET/EiJ ENSMSPG00010000981
 protein coding gene Chr7:132302748-132376907 (-)
WSB/EiJ ENSIUOG00005000894
 protein coding gene Chr7:133162794-133236247 (-)



Homology
more
  • Human Ortholog
    PPFIA1, PPFI scaffold protein A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPFIA1, PPFI scaffold protein A1
  • Synonyms
    LIP.1, LIP1, LIPRIN
  • Links
    NCBI Gene ID: 8500
    UniProt: Q13136

  • Chr Location
    11q13.3; chr11:70270655-70385312 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    57
  • cDNA Data
    164
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037519 Ensembl Gene Model | MGI Sequence Detail 76972 C57BL/6J ±  kb
transcript ENSMUST00000182226 Ensembl | MGI Sequence Detail 4829 Not Applicable  
polypeptide ENSMUSP00000138312 Ensembl | MGI Sequence Detail 1266 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 171
    cDNA 164
    Primer pair 7
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142372
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:389879 Emperador-Melero J, et al., Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release. Elife. 2026 Jun 17;14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory