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Tnfrsf11b Gene Detail
Summary
  • Symbol
    Tnfrsf11b
  • Name
    tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • Synonyms
    OCIF, Opg, OPG, osteoclastogenesis inhibitory factor, TR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109587
    NCBI Gene: 18383
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54114014-54141700 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 21.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    924 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109587
 protein coding gene Chr15:54114014-54141880 (-)
129S1/SvImJ ENSMUSG00200019314
 protein coding gene Chr15:51100529-51128375 (-)
A/J ENSMUSG00195006013
 protein coding gene Chr15:51131944-51159791 (-)
AKR/J ENSMUSG00220020750
 protein coding gene Chr15:51137198-51165063 (-)
BALB/cJ ENSMUSG00180008782
 protein coding gene Chr15:51079169-51107028 (-)
C3H/HeJ ENSMUSG00175004547
 protein coding gene Chr15:51337755-51365615 (-)
C57BL/6NJ ENSMUSG00215011498
 protein coding gene Chr15:51077139-51105000 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019789
 protein coding gene Chr15:48454156-48482076 (-)
CAST/EiJ ENSTCUG00005013788
 protein coding gene Chr15:50968163-50996087 (-)
CBA/J ENSMUSG00210006843
 protein coding gene Chr15:51160082-51187940 (-)
DBA/2J ENSMUSG00185026587
 protein coding gene Chr15:51140651-51168497 (-)
FVB/NJ ENSMUSG00205006634
 protein coding gene Chr15:50981371-51009218 (-)
JF1/MsJ ENSUMUG00000018881
 protein coding gene Chr15:50954620-50982484 (-)
LP/J ENSMUSG00230007037
 protein coding gene Chr15:54462062-54489911 (-)
NOD/ShiLtJ ENSMUSG00190016435
 protein coding gene Chr15:51126938-51154796 (-)
NZO/HlLtJ ENSMUSG00225028285
 protein coding gene Chr15:54784724-54812582 (-)
PWK/PhJ ENSLUMG00010026321
 protein coding gene Chr15:51209486-51237270 (-)
SPRET/EiJ ENSMSPG00010023826
 protein coding gene Chr15:52289163-52315488 (-)
WSB/EiJ ENSIUOG00005006015
 protein coding gene Chr15:51147818-51175663 (-)



Homology
more
  • Human Ortholog
    TNFRSF11B, TNF receptor superfamily member 11b
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF11B, TNF receptor superfamily member 11b
  • Synonyms
    OCIF, OPG, PDB5, TR1
  • Links
    NCBI Gene ID: 4982
    UniProt: O00300

  • Chr Location
    8q24.12; chr8:118923557-118952055 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnfrsf11b mouse models; 3 with human TNFRSF11B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 4 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation. Progressive hearing loss also results due to abnormal remodeling of the otic capsule.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    683
  • Tissues
    55
  • cDNA Data
    30
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18383 NCBI Gene Model | MGI Sequence Detail 27687 C57BL/6J ±  kb
    transcript NM_001411506 RefSeq | MGI Sequence Detail 2756 C57BL/6  
    polypeptide O08712 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016480 tumor necrosis factor receptor superfamily member 11B
      (term hierarchy)
    • PDB
      4E4D
    • InterPro Domains
      IPR000488 Death domain
      IPR011029 Death-like domain superfamily
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR052459 Tumor necrosis factor receptor superfamily decoy receptor
      IPR057633 Tumor necrosis factor receptor superfamily member 11B, Death domain
      IPR022323 Tumour necrosis factor receptor 11
      IPR017371 Tumour necrosis factor receptor 11B
    • GlyGen
      O08712 4 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 30
      Primer pair 11
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39586
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 14
      Phenotypes 86
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:385787 Jiang Q, et al., Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development. Front Cell Dev Biol. 2026;14:1770176
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory