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Symbol
Name
ID

Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
MGI:109587

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Cranial hyperostosis

Thickened calvaria

Macrocephaly

Relative macrocephaly

Bowing of the long bones

Lateral femoral bowing

Coarse metaphyseal trabecularization

Short humerus

Ankylosis

Recurrent fractures

Abnormal clavicle morphology

Barrel-shaped chest

Pectus carinatum

Kyphosis

Increased bone mineral density

Osteopenia

Osteoporosis

Disease(s) Associated with TNFRSF11B

Paget's disease of bone 5

Mouse Phenotypes

abnormal osteoclast differentiation

otosclerosis

abnormal parietal bone morphology

thin parietal bone

abnormal mandible morphology

abnormal middle ear ossicle morphology

abnormal incus body morphology

abnormal malleus morphology

abnormal stapes morphology

abnormal stapes annular ligament morphology

abnormal stapes footplate morphology

increased osteoclast cell number

abnormal osteoclast morphology

abnormal osteoclast physiology

short femur neck

abnormal long bone morphology

abnormal long bone epiphyseal plate morphology

abnormal long bone epiphysis morphology

increased diameter of long bones

abnormal bone structure

decreased bone mineral content

decreased bone mineral density

abnormal compact bone morphology

abnormal osteoblast morphology

abnormal trabecular bone morphology

absent bone trabeculae

decreased trabecular bone mass

osteoporosis

abnormal skeleton development

abnormal skeleton physiology

abnormal bone remodeling

fragile skeleton

Availability

Mouse Genotype

Tnfrsf11b^em1(IMPC)Mbp/Tnfrsf11b^em1(IMPC)Mbp

Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac

Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs

Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss

Tnfrsf11b^tm1Wss/Tnfrsf11b⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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