Sequence Detail

ID/Version

O08712 O70202 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Tumor necrosis factor receptor superfamily member 11B;AltName: Full=Osteoclastogenesis inhibitory factor;AltName: Full=Osteoprotegerin;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 401 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	21	112	3	16

Sequence references in MGI

J:39641 Simonet WS, et al., Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997 Apr 18;89(2):309-19
J:49549 Mizuno A, et al., Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis. Gene. 1998 Jul 30;215(2):339-43
J:64174 Min H, et al., Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis. J Exp Med. 2000 Aug 21;192(4):463-74
J:245306 Nelson CA, et al., RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor. Structure. 2012 Nov 07;20(11):1971-82