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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lhx1
LIM homeobox protein 1
MGI:99783
80 phenotypes from 8 alleles in 11 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
En1tm2(cre)Wrst/En1+
Lhx1tm2.1Bhr/Lhx1tm2.1Bhr
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
no abnormal phenotype detected J:123471
H2afvTg(Wnt1-cre)11Rth/?
Tg(CAG-Lhx,-EGFP)1Eno/?
involves: C3H * C57BL/6
failure of intramembranous bone ossification J:150709
frontal bone foramen J:150709
intracranial hemorrhage J:150709
neonatal lethality, complete penetrance J:150709
Lhx1tm1a(EUCOMM)Wtsi/Lhx1+
C57BL/6N-Lhx1tm1a(EUCOMM)Wtsi/Ics
decreased circulating alkaline phosphatase level J:165965
Lhx1tm1Bhr/Lhx1+
involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR
no abnormal phenotype detected J:98485
Lhx1tm1Bhr/Lhx1tm1Bhr
involves: 129S7/SvEvBrd
abnormal primitive streak elongation J:74124
abnormal primitive streak formation J:74124
abnormal rostral-caudal axis patterning J:74124
Lhx1tm1Bhr/Lhx1tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6
abnormal allantois morphology J:24115
abnormal anterior head development J:24115
abnormal brain development J:24115
abnormal egg cylinder morphology J:24115
abnormal gastrulation movements J:24115
abnormal hindbrain development J:24115
abnormal primitive node morphology J:24115
abnormal spinal cord morphology J:24115
absent forebrain J:24115
absent kidney J:24115
absent midbrain J:24115
absent ovary J:24115
absent prechordal mesoderm J:24115
absent testes J:24115
acephaly J:24115
agonadal J:24115
decreased embryo size J:24115
dilated allantois J:24115
embryonic lethality during organogenesis, incomplete penetrance J:24115
embryonic-extraembryonic boundary constriction J:24115
incomplete embryo turning J:24115
perinatal lethality, complete penetrance J:24115
rostral-caudal axis duplication J:24115
small allantois J:24115
Lhx1tm1Bhr/Lhx1tm1Tmj
involves: 129S/SvEv * C57BL/6
abnormal anterior head development J:98831
abnormal female reproductive system morphology J:98831
abnormal male reproductive system morphology J:98831
absent metanephros J:98831
absent ureter J:98831
Lhx1tm1Bhr/Lhx1tm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA
abnormal endoderm development J:226614
abnormal heart looping J:226614
abnormal heart morphology J:226614
abnormal nervous system development J:226614
abnormal primitive node morphology J:226614
cardia bifida J:226614
cellular necrosis J:226614
embryonic growth retardation J:226614
enlarged pericardium J:226614
Lhx1tm1Tmj/Lhx1tm2.1Bhr
Tg(Pax2-cre)10Shwl/0
involves: 129S1/SvEv * C57BL/6 * CD-1 * SJL
abnormal kidney morphology J:104938
abnormal ureter morphology J:104938
abnormal ureteric bud elongation J:104938
abnormal Wolffian duct morphology J:104938
duplex kidney J:104938
hydronephrosis J:104938
impaired branching involved in ureteric bud morphogenesis J:104938
neonatal lethality, complete penetrance J:104938
renal hypoplasia J:104938
rudimentary Mullerian ducts J:104938
rudimentary Wolffian ducts J:104938
single kidney J:104938
small kidney J:104938
Wolffian duct degeneration J:104938
Lhx1tm2.1Bhr/Lhx1tm1Tmj
Tg(Hoxb7-cre)13Amc/0
involves: 129S/SvEv * C57BL/6
abnormal mesonephros morphology J:98831
abnormal Mullerian duct morphology J:98831
abnormal ureter development J:98831
abnormal ureteric bud morphology J:98831
absent epididymis J:98831
absent Mullerian ducts J:98831
absent uterus J:98831
absent vas deferens J:98831
decreased nephron number J:98831
decreased renal glomerulus number J:98831
ectopic ureter J:98831
hydronephrosis J:98831
hydroureter J:98831
Mullerian duct degeneration J:98831
renal hypoplasia J:98831
rudimentary Mullerian ducts J:98831
small metanephros J:98831
uterus hypoplasia J:98831
Wolffian duct degeneration J:98831
Lhx1tm2.1Bhr/Lhx1tm1Tmj
Tg(Rarb-cre)1Bhr/0
involves: 129S/SvEv * C57BL/6 * SJL
abnormal kidney development J:98831
abnormal kidney medulla development J:98831
abnormal urinary bladder morphology J:98831
absent nephron J:98831
absent renal glomerulus J:98831
neonatal lethality, complete penetrance J:98831
renal hypoplasia J:98831
small metanephros J:98831
Lhx1tm3.1Bhr/Lhx1tm3.1Bhr
involves: 129S7/SvEvBrd * C57BL/6
abnormal anterior head development J:63192
abnormal neural tube morphology J:63192
abnormal primitive streak elongation J:63192
absent forebrain J:63192
absent midbrain J:63192
embryonic lethality during organogenesis, complete penetrance J:63192
embryonic-extraembryonic boundary constriction J:63192
Lhx1tm4Bhr/Lhx1tm4Bhr
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
neonatal lethality, complete penetrance J:123471

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory