Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sor+
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
decreased susceptibility to dopaminergic neuron neurotoxicity |
J:166896
|
Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
decreased dopaminergic neuron number |
J:166896
|
|
decreased susceptibility to dopaminergic neuron neurotoxicity |
J:166896
|
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-Otx2,-EGFP)1Eno/?
involves: C3H * C57BL/6
|
failure of intramembranous bone ossification |
J:150709
|
|
frontal bone foramen |
J:150709
|
|
intracranial hemorrhage |
J:150709
|
|
neonatal lethality, complete penetrance |
J:150709
|
Otx1tm4(cre)Asim/Otx1+
Otx2tm6Asim/Otx2tm6.1Asim
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
|
abnormal midbrain-hindbrain boundary morphology |
J:83110
|
|
abnormal neuronal precursor proliferation |
J:83110
|
|
abnormal tegmentum morphology |
J:83110
|
|
neonatal lethality, complete penetrance |
J:83110
|
|
small tectum |
J:83110
|
Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
129/Sv
|
abnormal eye development |
J:116888
|
|
abnormal forebrain development |
J:116888
|
|
abnormal inferior colliculus morphology |
J:116888
|
|
abnormal mandible morphology |
J:116888
|
|
abnormal midbrain morphology |
J:116888
|
|
decreased body size |
J:116888
|
|
decreased inferior colliculus size |
J:116888
|
|
loss of dopaminergic neurons |
J:116888
|
|
postnatal growth retardation |
J:116888
|
|
postnatal lethality |
J:116888
|
Otx2tm1.2Tlam/Otx2tm1.2Tlam
involves: C57BL/6 * DBA/2
|
embryonic-extraembryonic boundary constriction |
J:116888
|
Otx2tm1Pas/Otx2+
involves: C57BL/6 * FVB/N
|
abnormal gonadotroph morphology |
J:210118
|
|
decreased circulating luteinizing hormone level |
J:210118
|
|
decreased gonadotroph cell number |
J:210118
|
|
decreased litter size |
J:210118
|
|
decreased testis weight |
J:210118
|
|
preweaning lethality, incomplete penetrance |
J:210118
|
|
reduced male fertility |
J:210118
|
Otx2tm1Pas/Otx2tm1Pas
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal amnion morphology |
J:29276
|
|
abnormal developmental patterning |
J:29276
|
|
abnormal embryonic tissue morphology |
J:29276
|
|
abnormal hindbrain development |
J:29276
|
|
abnormal mesoderm development |
J:29276
|
|
abnormal neural tube morphology |
J:29276
|
|
abnormal primitive node morphology |
J:29276
|
|
abnormal somite development |
J:29276
|
|
abnormal somite shape |
J:29276
|
|
absent forebrain |
J:29276
|
|
absent midbrain |
J:29276
|
|
absent nasal placodes |
J:29276
|
|
absent optic vesicle |
J:29276
|
|
absent pharyngeal arches |
J:29276
|
|
decreased embryo size |
J:29276
|
|
embryonic growth retardation |
J:29276
|
|
prenatal lethality, complete penetrance |
J:29276
|
|
rostral body truncation |
J:29276
|
|
small heart |
J:29276
|
Otx2tm1Pas/Otx2tm2Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal brain development |
J:71034,
J:72725
|
|
abnormal first pharyngeal arch morphology |
J:71034
|
|
abnormal forebrain development |
J:71034
|
|
abnormal maxillary prominence morphology |
J:71034
|
|
abnormal midbrain development |
J:71034
|
|
acephaly |
J:71034,
J:72725
|
Otx2tm1Sia/Otx2+
involves: C57BL/6 * CBA
|
abnormal adenohypophysis morphology |
J:29682
|
|
abnormal alisphenoid bone morphology |
J:29682
|
|
abnormal anterior eye segment morphology |
J:29682
|
|
abnormal basisphenoid bone morphology |
J:29682
|
|
abnormal ciliary ganglion morphology |
J:29682
|
|
abnormal craniofacial morphology |
J:70745
|
|
abnormal cranium morphology |
J:29682
|
|
abnormal embryonic neuroepithelium morphology |
J:29682
|
|
abnormal extraocular muscle morphology |
J:29682
|
|
abnormal eye distance/ position |
J:29682
|
|
abnormal eye morphology |
J:51989
|
|
abnormal eyelid morphology |
J:29682
|
|
abnormal hindbrain morphology |
J:29682
|
|
abnormal incus morphology |
J:29682
|
|
abnormal inferior colliculus morphology |
J:29682
|
|
abnormal malleus morphology |
J:29682
|
|
abnormal mandible morphology |
J:29682,
J:51989
|
|
abnormal Meckel's cartilage morphology |
J:29682
|
|
abnormal midbrain-hindbrain boundary morphology |
J:29682
|
|
abnormal nasal capsule morphology |
J:29682
|
|
abnormal nasal cavity morphology |
J:29682
|
|
abnormal nasal septum morphology |
J:29682
|
|
abnormal oculomotor nerve morphology |
J:29682
|
|
abnormal olfactory epithelium morphology |
J:29682
|
|
abnormal palate morphology |
J:29682
|
|
abnormal presphenoid bone morphology |
J:29682
|
|
abnormal pterygoid bone morphology |
J:29682
|
|
abnormal retina layer morphology |
J:29682
|
|
abnormal sclera morphology |
J:29682
|
|
abnormal snout morphology |
J:29682
|
|
abnormal temporal bone tympanic part morphology |
J:29682
|
|
abnormal third ventricle morphology |
J:29682
|
|
abnormal trigeminal nerve morphology |
J:29682
|
|
abnormal trigeminal V mesencephalic nucleus morphology |
J:29682
|
|
abnormal trochlear nerve morphology |
J:29682
|
|
abnormal vomeronasal organ morphology |
J:29682
|
|
absent choroid plexus |
J:29682
|
|
absent cornea |
J:29682
|
|
absent forebrain |
J:29682
|
|
absent mandible |
J:29682
|
|
absent mandibular coronoid process |
J:29682
|
|
absent metencephalon |
J:29682
|
|
absent midbrain |
J:29682
|
|
absent nasal capsule |
J:29682
|
|
absent nasal septum |
J:29682
|
|
absent nasopharynx |
J:29682
|
|
absent olfactory bulb |
J:29682
|
|
absent orbitosphenoid bone |
J:29682
|
|
absent tongue |
J:29682
|
|
absent vomeronasal organ |
J:29682
|
|
acephaly |
J:29682,
J:51989
|
|
aniridia |
J:29682
|
|
anophthalmia |
J:29682
|
|
aphakia |
J:29682
|
|
basisphenoid bone foramen |
J:29682
|
|
decreased embryonic neuroepithelium thickness |
J:29682
|
|
ethmocephaly |
J:29682
|
|
micrognathia |
J:29682
|
|
microphthalmia |
J:29682
|
|
neonatal lethality, incomplete penetrance |
J:29682
|
|
premature death |
J:29682
|
|
retina pigment epithelium hyperplasia |
J:29682
|
|
short snout |
J:29682
|
|
small cranium |
J:29682
|
Otx2tm1Sia/Otx2tm1Sia
involves: C57BL/6 * CBA
|
abnormal anterior head development |
J:29682
|
|
abnormal brain development |
J:51989
|
|
abnormal gastrulation |
J:51989
|
|
abnormal mesendoderm development |
J:51989
|
|
absent forebrain |
J:29682
|
|
absent foregut |
J:29682
|
|
absent heart |
J:29682
|
|
absent midbrain |
J:29682
|
|
embryonic growth arrest |
J:29682
|
|
embryonic lethality during organogenesis, complete penetrance |
J:29682
|
|
rostral body truncation |
J:29682
|
Otx2tm1Sia/Otx2tm4.1Sia
involves: C57BL/6 * CBA * FVB/N
|
no abnormal phenotype detected |
J:74631
|
Otx2tm1Sia/Otx2tm4Sia
involves: C57BL/6 * CBA
|
abnormal brain development |
J:74631
|
|
abnormal cranium morphology |
J:74631
|
|
abnormal metencephalon morphology |
J:74631
|
|
abnormal midbrain morphology |
J:74631
|
|
abnormal midbrain-hindbrain boundary morphology |
J:74631
|
|
abnormal nervous system development |
J:74631
|
|
absent diencephalon |
J:74631
|
|
absent embryonic telencephalon |
J:74631
|
|
anencephaly |
J:74631
|
|
normal
embryo phenotype |
J:74631
|
|
exencephaly |
J:74631
|
|
open neural tube |
J:74631
|
Otx2tm1Sia/Otx2tm5Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
abnormal brain development |
J:91011
|
|
absent diencephalon |
J:91011
|
|
absent midbrain |
J:91011
|
Otx2tm1Sia/Otx2tm6Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
abnormal brain development |
J:91011
|
Otx2tm1Sia/Otx2tm9Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
abnormal embryonic neuroepithelium morphology |
J:207608
|
|
abnormal forebrain morphology |
J:207608
|
Otx2tm1Sia/Otx2tm10Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
abnormal embryonic neuroepithelium morphology |
J:207608
|
|
abnormal forebrain morphology |
J:207608
|
Otx2tm1Sla/Otx2+
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
open neural tube |
J:30828
|
|
preweaning lethality, incomplete penetrance |
J:30828
|
Otx2tm1Sla/Otx2tm1Sla
involves: 129S1/Sv * 129X1/SvJ
|
abnormal primitive streak elongation |
J:74124
|
|
abnormal primitive streak formation |
J:74124
|
|
abnormal rostral-caudal axis patterning |
J:74124
|
Otx2tm1Sla/Otx2tm1Sla
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
abnormal allantois morphology |
J:30828
|
|
abnormal axial mesoderm morphology |
J:30828
|
|
abnormal brain development |
J:30828
|
|
abnormal developmental patterning |
J:30828
|
|
abnormal ectoderm development |
J:30828
|
|
abnormal gastrulation |
J:30828
|
|
abnormal mesoderm development |
J:30828
|
|
abnormal neural tube morphology |
J:30828
|
|
abnormal notochord morphology |
J:30828
|
|
abnormal primitive streak formation |
J:30828
|
|
abnormal somite shape |
J:30828
|
|
abnormal visceral yolk sac endoderm morphology |
J:30828
|
|
abnormal visceral yolk sac mesenchyme morphology |
J:30828
|
|
abnormal visceral yolk sac morphology |
J:30828
|
|
absent forebrain |
J:30828
|
|
absent metencephalon |
J:30828
|
|
absent midbrain |
J:30828
|
|
absent prechordal mesoderm |
J:30828
|
|
decreased embryo size |
J:30828
|
|
embryonic growth retardation |
J:30828
|
|
embryonic lethality during organogenesis, complete penetrance |
J:30828
|
|
embryonic-extraembryonic boundary constriction |
J:30828
|
|
fused somites |
J:30828
|
|
impaired somite development |
J:30828
|
|
rostral body truncation |
J:30828
|
Otx2tm1Sla/Otx2tm2Sla
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
abnormal hindbrain development |
J:46641
|
|
absent forebrain |
J:46641
|
|
absent midbrain |
J:46641
|
Otx2tm2.1Imat/Otx2tm2.1Imat
involves: C57BL/6 * CBA
|
abnormal rostral-caudal axis patterning |
J:64866
|
|
acephaly |
J:64866
|
Otx2tm2.1Imat/Otx2tm7Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
abnormal forebrain development |
J:91012
|
|
absent forebrain |
J:91012
|
|
absent midbrain |
J:91012
|
|
normal
embryo phenotype |
J:91012
|
Otx2tm2Asim/Otx2tm2Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal brain development |
J:71034
|
|
abnormal forebrain development |
J:71034
|
|
abnormal midbrain development |
J:71034
|
|
abnormal motor capabilities/coordination/movement |
J:71034
|
|
anencephaly |
J:71034
|
|
decreased forebrain size |
J:71034
|
|
decreased midbrain size |
J:71034
|
|
exencephaly |
J:71034
|
|
microcephaly |
J:71034
|
|
open neural tube |
J:71034
|
|
reduced fertility |
J:71034
|
Otx2tm3Tlam/Otx2tm3Tlam
129/Sv-Otx2tm3Tlam
|
abnormal brain development |
J:130649
|
|
abnormal diencephalon morphology |
J:130649
|
|
abnormal facial morphology |
J:130649
|
|
abnormal midbrain morphology |
J:130649
|
|
postnatal lethality, incomplete penetrance |
J:130649
|
Otx2tm4.1Sia/Otx2tm4.1Sia
involves: C57BL/6 * CBA
|
no abnormal phenotype detected |
J:74631
|
Otx2tm4.2Sia/Otx2+
involves: C57BL/6 * CBA * FVB/N
|
no abnormal phenotype detected |
J:74631
|
Otx2tm4Sia/Otx2tm4Sia
involves: C57BL/6 * CBA
|
perinatal lethality, incomplete penetrance |
J:74631
|
|
postnatal lethality, complete penetrance |
J:74631
|
Otx2tm5Sia/Otx2tm5Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
normal
nervous system phenotype |
J:91011
|
Otx2tm6Asim/Otx2tm11Asim
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
|
abnormal neuron differentiation |
J:166896
|
|
increased susceptibility to dopaminergic neuron neurotoxicity |
J:166896
|
Otx2tm6Sia/Otx2tm6Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
normal
nervous system phenotype |
J:91011
|
Otx2tm7Sia/Otx2+
Tg(Lefty2-cre)21bHmd/?
involves: C57BL/6NCrlj * CBA/JNCrlj
|
normal
embryo phenotype |
J:91012
|
Otx2tm7Sia/Otx2tm7Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
normal
embryo phenotype |
J:91012
|
|
normal
nervous system phenotype |
J:91012
|
Otx2tm8.2Sia/Otx2tm8.2Sia
involves: C57BL/6 * CBA
|
abnormal brain development |
J:166617
|
|
abnormal cerebral cortex morphology |
J:166617
|
Otx2tm8Asim/Otx2tm8Asim
involves: 129P2/OlaHsd
|
no abnormal phenotype detected |
J:153562
|
|
normal
reproductive system phenotype |
J:153562
|
Otx2tm9Asim/Otx2tm9Asim
involves: 129P2/OlaHsd
|
abnormal craniofacial morphology |
J:153562
|
|
abnormal forebrain development |
J:153562
|
|
abnormal midbrain development |
J:153562
|
|
acephaly |
J:153562
|
|
exencephaly |
J:153562
|
Otx2tm9Asim/Otx2tm10Asim
involves: 129P2/OlaHsd
|
normal
embryo phenotype |
J:153562
|
Otx2tm9Asim/Otx2tm11Asim
involves: 129P2/OlaHsd
|
abnormal forebrain development |
J:153562
|
|
abnormal midbrain development |
J:153562
|
|
acephaly |
J:153562
|
Otx2tm9Sia/Otx2tm9Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
abnormal embryonic neuroepithelium morphology |
J:207608
|
|
abnormal forebrain morphology |
J:207608
|
Otx2tm10Asim/Otx2tm10Asim
involves: 129P2/OlaHsd
|
abnormal embryo development |
J:153562
|
|
abnormal forebrain morphology |
J:153562
|
|
abnormal head morphology |
J:153562
|
Otx2tm10Asim/Otx2tm11Asim
involves: 129P2/OlaHsd
|
abnormal embryo development |
J:153562
|
|
abnormal head morphology |
J:153562
|
Otx2tm10Sia/Otx2tm10Sia
involves: C57BL/6NCrlj * CBA/JNCrlj
|
abnormal embryonic neuroepithelium morphology |
J:207608
|
|
abnormal forebrain morphology |
J:207608
|
Otx2tm11Asim/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal cone electrophysiology |
J:207121
|
|
abnormal retina bipolar cell morphology |
J:207121
|
|
abnormal retina horizontal cell morphology |
J:207121
|
|
abnormal rod electrophysiology |
J:207121
|
|
decreased retina cone cell number |
J:207121
|
|
decreased visual acuity |
J:207121
|
|
thin retina inner nuclear layer |
J:207121
|
|
normal
vision/eye phenotype |
J:207121
|
Otx2tm11Asim/Otx2tm11Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
embryonic lethality during organogenesis, complete penetrance |
J:207121
|
Otx2tm12.1Asim/Otx2+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal rod electrophysiology |
J:207121
|
|
decreased retina cone cell number |
J:207121
|
|
decreased retina ganglion cell number |
J:207121
|
|
thin retina inner nuclear layer |
J:207121
|
|
thin retina outer nuclear layer |
J:207121
|
|
normal
vision/eye phenotype |
J:207121
|
Otx2tm12.1Asim/Otx2tm11Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal head morphology |
J:207121
|
|
forebrain hypoplasia |
J:207121
|
|
midbrain hypoplasia |
J:207121
|
|
neonatal lethality, complete penetrance |
J:207121
|
Otx2tm12.1Asim/Otx2tm12.1Asim
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal cone electrophysiology |
J:207121
|
|
abnormal iris morphology |
J:207121
|
|
abnormal optic nerve morphology |
J:207121
|
|
abnormal retina bipolar cell morphology |
J:207121
|
|
abnormal retina horizontal cell morphology |
J:207121
|
|
abnormal retina morphology |
J:207121
|
|
abnormal retina pigment epithelium morphology |
J:207121
|
|
abnormal rod electrophysiology |
J:207121
|
|
anophthalmia |
J:207121
|
|
decreased retina cone cell number |
J:207121
|
|
decreased retina ganglion cell number |
J:207121
|
|
decreased retina photoreceptor cell number |
J:207121
|
|
decreased visual acuity |
J:207121
|
|
microphthalmia |
J:207121
|
|
normal
mortality/aging |
J:207121
|
|
normal
nervous system phenotype |
J:207121
|
|
thin retina inner nuclear layer |
J:207121
|
|
thin retina outer nuclear layer |
J:207121
|
|
normal
vision/eye phenotype |
J:207121
|
Excel File
Analysis Tools