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Otx1tm4(cre)Asim
Targeted Allele Detail
Summary
Symbol: Otx1tm4(cre)Asim
Name: orthodenticle homeobox 1; targeted mutation 4, Antonio Simeone
MGI ID: MGI:2661060
Synonyms: Otx1cre
Gene: Otx1  Location: Chr11:21944764-21952897 bp, - strand  Genetic Position: Chr11, 14.1 cM
Alliance: Otx1tm4(cre)Asim page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83110
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Otx1tm4(cre)Asim expression driven by 1 gene
 
Mutation detailsExon 2 and part of exon 1 were deleted and replaced with a cre-neo cassette via homologous recombination, resulting in cre expression under Otx1 regulatory elements. (J:83110)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Otx1 (mouse)
Summary of all recombinase alleles driven by Otx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Otx1 Mutation:  86 strains or lines available
References
Original:  J:83110 Puelles E, et al., Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci. 2003 May;6(5):453-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory