Nras Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nras
neuroblastoma ras oncogene
MGI:97376

34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Ezh2^tm1.1Nesh/Ezh2⁺ Nras^tm1.1Nesh/Nras⁺ Tg(Tyr-cre/ERT2)13Bos/0 involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB	increased melanoma incidence	J:239472
Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Nras^tm1.1Nesh/Nras⁺ Tg(Tyr-cre/ERT2)13Bos/0 involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB	increased melanoma incidence	J:239472
Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Nras^tm1.1Nesh/Nras^tm1.1Nesh Stk11^tm1.1Rdp/Stk11^tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos/0 B6J.Cg-Tg(Tyr-cre/ERT2)13Bos Nras^tm1.1Nesh Cdkn2a^tm2.1Nesh Stk11^tm1.1Rdp	increased cutaneous melanoma incidence	J:220627
	increased metastatic potential	J:220627
Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Nras^tm1.1Nesh/Nras^tm1.1Nesh Tg(Tyr-cre/ERT2)13Bos/0 B6J.Cg-Tg(Tyr-cre/ERT2)13Bos Nras^tm1.1Nesh Cdkn2a^tm2.1Nesh	abnormal melanocyte proliferation	J:220627
	hyperpigmentation	J:220627
	increased cutaneous melanoma incidence	J:220627
Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre/ERT2)13Bos/0 B6J.Cg-Tg(Tyr-cre/ERT2)13Bos Nras^tm1Tyj Cdkn2a^tm2.1Nesh	abnormal melanocyte proliferation	J:220627
	hyperpigmentation	J:220627
	increased cutaneous melanoma incidence	J:220627
Ezh2^tm1.1Nesh/Ezh2⁺ Nras^tm1.1Nesh/Nras⁺ Tg(Tyr-cre/ERT2)13Bos/0 involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB	normal neoplasm	J:239472
Hras^tm1Esn/Hras^tm1Esn Nras^tm1Rak/Nras^tm1Rak involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6N	no abnormal phenotype detected	J:67374
Hras^tm1Mok/Hras⁺ Nras^tm1Mok/Nras^tm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ Tg(HRAS)2Jic/0 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)7Mok/0 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	no abnormal phenotype detected	J:135610
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	prenatal lethality, incomplete penetrance	J:135610
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:159024
Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ B6.129S-Nras^tm1Mok Kras^tm1Mok	chylous ascites	J:159024
Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	abnormal lymphatic vessel morphology	J:159024
	chylous ascites	J:159024
Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras^tm1Mok either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	perinatal lethality, incomplete penetrance	J:135610
	postnatal lethality, complete penetrance	J:135610
Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras^tm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:159024
Kras^tm1Tyj/Kras⁺ Nras^tm1Rak/Nras^tm1Rak involves: 129/Sv * C57BL/6	abnormal embryonic hematopoiesis	J:43433
	abnormal erythropoiesis	J:43433
	abnormal eye development	J:43433
	abnormal hepatocyte morphology	J:43433
	absent visceral yolk sac blood islands	J:43433
	anemia	J:43433
	dilated heart	J:43433
	distended pericardium	J:43433
	embryonic growth arrest	J:43433
	embryonic growth retardation	J:43433
	embryonic lethality during organogenesis, incomplete penetrance	J:43433
	excessive folding of visceral yolk sac	J:43433
	hydrops fetalis	J:43433
	increased apoptosis	J:43433
	increased embryonic tissue cell apoptosis	J:43433
	pale yolk sac	J:43433
	pallor	J:43433
	perinatal lethality, incomplete penetrance	J:43433
	postnatal lethality, complete penetrance	J:43433
	short tail	J:43433
Kras^tm1Tyj/Kras^tm1Tyj Nras^tm1Rak/Nras⁺ involves: 129/Sv * C57BL/6	embryonic lethality, incomplete penetrance	J:43433
Kras^tm1Tyj/Kras^tm1Tyj Nras^tm1Rak/Nras^tm1Rak involves: 129/Sv * C57BL/6	embryonic lethality, complete penetrance	J:43433
Zdhhc9^tm1Lex/Y Nras^tm1Tyj/Nras^tm1Tyj Tg(Mx1-cre)1Cgn/0 involves: 129S5/SvEvBrd * C57BL/6 * CBA	decreased leukemia incidence	J:231488

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