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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lck
lymphocyte protein tyrosine kinase
MGI:96756
35 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccnd3tm1Pisc/Ccnd3tm1Pisc
Tg(Lck)4220Rmp/0
involves: C57BL/6J * DBA/2 		decreased lymphoma incidence J:88120
decreased tumor-free survival time J:88120
increased T cell derived lymphoma incidence J:88120
Cd247tm1Mal/Cd247tm1Mal
Lcktm1Mak/Lcktm1Mak
involves: 129S2/SvPas * C57BL/6 		abnormal double-negative T cell morphology J:110847
abnormal T cell differentiation J:110847
abnormal T cell morphology J:110847
abnormal thymocyte activation J:110847
decreased double-positive T cell number J:110847
Fyntm1Rmp/Fyntm1Rmp
Lcktm1Mak/Lcktm1Mak
involves: 129S2/SvPas 		abnormal alpha-beta intraepithelial T cell morphology J:112977
abnormal NK T cell number J:37940
absent CD4-positive, alpha-beta T cells J:37940
absent CD8-positive, alpha-beta T cells J:37940
absent T cells J:37062
arrested T cell differentiation J:37062, J:37940
decreased double-positive T cell number J:37940
decreased gamma-delta intraepithelial T cell number J:37940, J:112977
thymus hypoplasia J:37062, J:37940
Fyntm1Sor/Fyntm1Sor
Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S7/SvEvBrd * 129X1/SvJ 		abnormal regulatory T cell physiology J:152472
decreased regulatory T cell number J:152472
decreased T cell proliferation J:152472
enlarged lymph nodes J:152472
increased regulatory T cell number J:152472
increased T cell number J:152472
Il2rbtm1Mak/Il2rbtm1Mak
Lcktm1Mak/Lcktm1Mak
involves: 129 		abnormal endometrium morphology J:134589
abnormal maternal decidual layer morphology J:134589
absent endometrial glands J:134589
absent uterine NK cells J:134589
Lattm4.1Mal/Lattm4.1Mal
Tg(Lck*F505)3073Rmp/?
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal T-helper 2 physiology J:151840
increased CD4-positive, alpha-beta T cell number J:151840
increased IgE level J:151840
increased IgG1 level J:151840
increased interleukin-4 secretion J:151840
spleen hyperplasia J:151840
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C3H * C57BL/6 * DBA/2J 		abnormal positive T cell selection J:114660
abnormal T cell differentiation J:114660
arrested T cell differentiation J:114660
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)425Cbn/0
involves: C3H * C57BL/6 		abnormal positive T cell selection J:114660
arrested T cell differentiation J:114660
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)1100Mjb/0
involves: C3H * C57BL/6 		abnormal positive T cell selection J:114660
decreased T cell proliferation J:114660
Lcktm1Mak/Lcktm1Mak
Rag1tm1Mom/Rag1+
Tg(Lck-Fyn*Y528F)5525Cjg/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal T cell differentiation J:37062
decreased T cell number J:37062
Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)2964Rmp/?
involves: 129/Sv * C57BL/6 * DBA/2 		increased T cell derived lymphoma incidence J:64671
thymus hyperplasia J:64671
Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)3073Rmp/?
involves: 129/Sv * C57BL/6 * DBA/2 		increased T cell derived lymphoma incidence J:64671
thymus hyperplasia J:64671
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory