Tg(Lck*F505)3073Rmp
Transgene Detail

Summary

• Symbol: Tg(Lck*F505)3073Rmp
• Name: transgene insertion 3073, Roger M Perlmutter
• MGI ID: MGI:3032775
• Synonyms: pLGFC, pLGF-C
• Transgene: Tg(Lck*F505)3073Rmp Location: unknown
• Alliance: Tg(Lck*F505)3073Rmp page

Transgene origin

• Strain of Origin: (DBA/2 x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck*F505)3073Rmp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lck (MGI:96756)

• Mutation details: The transgene contains 1kb of genomic sequence 5' of the start codon and the entire coding sequence of the murine gene through exon 11. Exon 12 is derived from mouse cDNA sequence modified so that phenylalanine is coded for at position 505 rather than tyrosine. These fragments are linked to a 3' untranslated region segment from hGH containing a single polyadenylation site. The resulting transgene is under the control of the proximal promoter element of the mouse gene and results in the production of 6 pg of mRNA per ug of total RNA. (J:88309)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88309 Abraham KM, et al., Thymic tumorigenesis induced by overexpression of p56lck. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3977-81
• All: 4 reference(s)