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Lck Gene Detail
Summary
  • Symbol
    Lck
  • Name
    lymphocyte protein tyrosine kinase
  • Synonyms
    Hck-3, p56lck
  • Feature Type
    protein coding gene
  • IDs
    MGI:96756
    NCBI Gene: 16818
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129442137-129467434 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.26 cM, cytoband distal
  • Mapping Data
    60 experiments
  • Sequence Tag
    D4Nds20
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96756
 protein coding gene Chr4:129442137-129467434 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028828
 protein coding gene Chr4:131479407-131510796 (-)
A/J MGP_AJ_G0028787
 protein coding gene Chr4:126225864-126251421 (-)
AKR/J MGP_AKRJ_G0028740
 protein coding gene Chr4:129746086-129773420 (-)
BALB/cJ MGP_BALBcJ_G0028810
 protein coding gene Chr4:126829849-126858493 (-)
C3H/HeJ MGP_C3HHeJ_G0028524
 protein coding gene Chr4:129796665-129824989 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029252
 protein coding gene Chr4:136426404-136451032 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026524
 protein coding gene Chr4:119356594-119380153 (-)
CAST/EiJ MGP_CASTEiJ_G0027956
 protein coding gene Chr4:127982134-128011048 (-)
CBA/J MGP_CBAJ_G0028490
 protein coding gene Chr4:139801893-139843113 (-)
DBA/2J MGP_DBA2J_G0028639
 protein coding gene Chr4:126660025-126686742 (-)
FVB/NJ MGP_FVBNJ_G0028606
 protein coding gene Chr4:125418087-125443651 (-)
LP/J MGP_LPJ_G0028740
 protein coding gene Chr4:131756787-131787457 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028632
 protein coding gene Chr4:144629300-144656931 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029290
 protein coding gene Chr4:130114117-130141019 (-)
PWK/PhJ MGP_PWKPhJ_G0027678
 protein coding gene Chr4:123262862-123288361 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027504
 protein coding gene Chr4:125977347-126007300 (-)
WSB/EiJ MGP_WSBEiJ_G0028037
 protein coding gene Chr4:130236359-130267511 (-)



Homology
more
  • Human Ortholog
    LCK, LCK proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCK, LCK proto-oncogene, Src family tyrosine kinase
  • Synonyms
    IMD22, LSK, p56lck, pp58lck, YT16
  • Links
    NCBI Gene ID: 3932
    neXtProt AC: NX_P06239
    UniProt: P06239

  • Chr Location
    1p35.2; chr1:32251239-32286167 (+)  GRCh38.p7
  • Alliance of Genome Resources
    Lck stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: LCK
  • Gene Tree
    Lck
Human Diseases
more
  • Diseases
    1 with human LCK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 10 alleles in 9 genetic backgrounds
    35 phenotypes from multigenic genotypes
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations of this gene exhibit thymic atrophy with reduced numbers of peripheral T cells. Null mutants have few double positive and no mature single positive (SP) thymocytes. A hypomorph has decreased expression of CD3epsilon chain onSP thymocytes, whose numbers are reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    20
  • cDNA Data
    26
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16818 NCBI Gene Model | MGI Sequence Detail 25298 C57BL/6J ±  kb
    transcript NM_010693 RefSeq | MGI Sequence Detail 2166 C57BL/6  
    polypeptide P06240 UniProt | EBI | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 8
      cDNA 30
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10669, MGD-MRK-11758
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 5
      Gene Ontology 36
      Phenotypes 106
    • Earliest
      J:8130 Marth JD, et al., A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 1985 Dec;43(2 Pt 1):393-404
    • Latest
      J:305737 Marklin M, et al., Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia. Front Immunol. 2020;11:1995
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/31/2023
    MGI 6.22     		The Jackson Laboratory