Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprctm1Holm mutation
(11 available);
any
Ptprc mutation
(188 available)
Tg(Lck*F505)3073Rmp mutation
(0 available)
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neoplasm
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• aggressive thymic tumors in 100% of mice
• earliest morbidity at 10 weeks and median survival was to 12 weeks
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immune system
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• thymus glands with tumours also have 5X normal cell numbers
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hematopoietic system
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• thymus glands with tumours also have 5X normal cell numbers
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endocrine/exocrine glands
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• thymus glands with tumours also have 5X normal cell numbers
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• aggressive thymic tumors in 100% of mice
• earliest morbidity at 10 weeks and median survival was to 12 weeks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm4.1Mal mutation
(0 available);
any
Lat mutation
(9 available)
Tg(Lck*F505)3073Rmp mutation
(0 available)
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immune system
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• spleen cellularity is increased 3-fold compared to transgenics on a wild-type background
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• CD4+CD5+ T cell numbers are increased over 5-fold compared to controls
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• serum IgE levels are about 10,000-fold higher than controls
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• serum IgG1 levels are more than 100-fold higher than controls
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• transgene allows rescue of deficient thymocyte development of Lat-null mice
• 60% of these T cells express IL-4 upon PMA stimulation
• Th2 T cells hyper proliferate and stimulate immunoglobulin production
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• 60% of peripheral T cells express IL-4 upon PMA stimulation
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hematopoietic system
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• spleen cellularity is increased 3-fold compared to transgenics on a wild-type background
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• CD4+CD5+ T cell numbers are increased over 5-fold compared to controls
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• serum IgE levels are about 10,000-fold higher than controls
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• serum IgG1 levels are more than 100-fold higher than controls
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• transgene allows rescue of deficient thymocyte development of Lat-null mice
• 60% of these T cells express IL-4 upon PMA stimulation
• Th2 T cells hyper proliferate and stimulate immunoglobulin production
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growth/size/body
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• spleen cellularity is increased 3-fold compared to transgenics on a wild-type background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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neoplasm
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• unlike mice carrying transgenes of this gene which express greater than 20 pg of mRNA per ug of total RNA, no thymic tumors develop during the first year of life
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Analysis Tools