Lck^tm1.1Litt
Targeted Allele Detail

Summary

• Symbol: Lck^tm1.1Litt
• Name: lck proto-oncogene, Src family tyrosine kinase; targeted mutation 1.1, Dan R Littman
• MGI ID: MGI:4358985
• Gene: Lck Location: Chr4:129442142-129467415 bp, - strand Genetic Position: Chr4, 63.26 cM, cytoband distal
• Alliance: Lck^tm1.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152472
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre recombination removes exons 1 through 3. Due to a cryptic splice site cre recombination of this allele produces a truncated transcript lacking the amino-terminal myristylation sequence, the CD4/CD8-interaction domain, and the epitope recognized by the 1F6 monoclonal antibody. This transcipt is generated from thymic transcipts that derive from the proximal promoter but not from the peripheral T cell transcripts deriving from the distal promoter. (J:152472)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lck Mutation: 96 strains or lines available

References

• Original: J:152472 Kim JK, et al., Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One. 2009;4(8):e6580
• All: 1 reference(s)