Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1.1Litt mutation
(0 available);
any
Lck mutation
(93 available)
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immune system
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• authors state that mice exhibit the same phenotype as Lcktm1Mak homozygotes
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• authors state that mice exhibit the same phenotype as Lcktm1Mak homozygotes
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• authors state that mice exhibit the same phenotype as Lcktm1Mak homozygotes
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hematopoietic system
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• authors state that mice exhibit the same phenotype as Lcktm1Mak homozygotes
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• authors state that mice exhibit the same phenotype as Lcktm1Mak homozygotes
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• authors state that mice exhibit the same phenotype as Lcktm1Mak homozygotes
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endocrine/exocrine glands
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• authors state that mice exhibit the same phenotype as Lcktm1Mak homozygotes
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immune system
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• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
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• in the thymus and spleen
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• regulatory T cell turnover is impaired and suppressive function is lost
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hematopoietic system
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• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
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• in the thymus and spleen
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• regulatory T cell turnover is impaired and suppressive function is lost
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cellular
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• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1.1Litt mutation
(0 available);
any
Lck mutation
(93 available)
Lcktm1Litt mutation
(0 available);
any
Lck mutation
(93 available)
Tnfrsf4tm2(cre)Nik mutation
(1 available);
any
Tnfrsf4 mutation
(33 available)
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immune system
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• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
|
|
• in the thymus and spleen
|
|
• regulatory T cell turnover is impaired and suppressive function is lost
|
hematopoietic system
|
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
|
|
• in the thymus and spleen
|
|
• regulatory T cell turnover is impaired and suppressive function is lost
|
cellular
|
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
|