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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il13
interleukin 13
MGI:96541
80 phenotypes from 8 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
C.129P2/OlaHsd-Il4/Il13tm3Anjm 		abnormal interleukin-4 secretion J:91403
decreased IgE level J:91403
decreased interferon-gamma secretion J:91403
decreased interleukin-5 secretion J:91403
decreased interleukin-13 secretion J:91403
decreased susceptibility to autoimmune disorder J:91403
increased IgG2a level J:91403
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
C.Cg-Il4/Il13tm3Anjm 		decreased susceptibility to injury J:88681
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
involves: 129P2/OlaHsd * BALB/c 		abnormal mammary gland growth during pregnancy J:124116
abnormal splenocyte physiology J:60609
abnormal susceptibility to infection J:60609, J:131994
decreased IgG1 level J:178986
decreased inflammatory response J:60609, J:165513
ileum inflammation J:60609
increased susceptibility to parasitic infection J:60609
increased susceptibility to parasitic infection induced morbidity/mortality J:60609
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
involves: 129P2/OlaHsd * C57BL/6 		abnormal immune system physiology J:89095
abnormal intestinal goblet cell morphology J:113543
abnormal splenocyte physiology J:72587
abnormal susceptibility to infection J:113543
abnormal T-helper 2 physiology J:89095
decreased IgE level J:72587, J:113543
decreased IgG1 level J:72587
decreased IgG level J:89095
decreased susceptibility to parasitic infection J:72587
granulomatous inflammation J:113543
increased eosinophil cell number J:113543
increased susceptibility to parasitic infection J:89095, J:113543
increased susceptibility to parasitic infection induced morbidity/mortality J:60609
Il13tm1.1(KOMP)Vlcg/Il13tm1.1(KOMP)Vlcg
C57BL/6N-Il13tm1.1(KOMP)Vlcg/MbpMmucd 		increased pulmonary ventilation J:211773
Il13tm1.1(KOMP)Vlcg/Il13tm1.1(KOMP)Vlcg
C57BL/6N-Il13tm1.1(KOMP)Vlcg/Ucd 		increased circulating HDL cholesterol level J:211773
Il13tm1.1Anjm/Il13tm1.1Anjm
C.129P2-Il13tm1.1Anjm 		abnormal dendritic cell antigen presentation J:141937
abnormal dendritic cell differentiation J:141937
decreased IgE level J:91403
decreased interleukin-5 secretion J:141937
decreased interleukin-13 secretion J:91403, J:141937
decreased susceptibility to autoimmune disorder J:91403, J:141937
increased IgG2a level J:91403
increased interferon-gamma secretion J:141937
Il13tm1.1Anjm/Il13tm1.1Anjm
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 2 cell differentiation J:67965
decreased circulating interleukin-13 level J:67965
decreased IgE level J:67965
decreased interleukin-4 secretion J:67965
decreased interleukin-5 secretion J:67965
decreased interleukin-10 secretion J:67965
decreased T-helper 2 cell number J:67965
increased IgG2b level J:67965
increased IgM level J:67965
increased interferon-gamma secretion J:67965
Il13tm1Anjm/Il13tm1Anjm
C.129P2-Il13tm1Anjm 		decreased interleukin-4 secretion J:69099
decreased interleukin-13 secretion J:69099
Il13tm1Anjm/Il13tm1Anjm
involves: 129P2/OlaHsd * C57BL/6 		abnormal interleukin secretion J:82881
abnormal intestinal goblet cell morphology J:82881
decreased eosinophil cell number J:82881
decreased interleukin-4 secretion J:82881
decreased interleukin-5 secretion J:82881
decreased interleukin-9 secretion J:82881
granulomatous inflammation J:82881, J:113543
increased susceptibility to parasitic infection J:113543
pulmonary fibrosis J:82881
Il13tm2Anjm/Il13tm2Anjm
B6.129P2-Il13tm2Anjm 		abnormal antigen presentation J:131969
abnormal leukocyte physiology J:131969
decreased macrophage cell number J:131969
decreased susceptibility to experimental autoimmune encephalomyelitis J:131969
Il13tm2Anjm/Il13tm2Anjm
C.129P2(B6)-Il13tm2Anjm 		abnormal response to transplant J:110188
abnormal type I hypersensitivity reaction J:123772
decreased susceptibility to injury J:88681
increased length of allograft survival J:110188
increased susceptibility to type I hypersensitivity reaction J:123772
Il13tm2Anjm/Il13tm2Anjm
involves: 129 		abnormal T-helper 2 cell differentiation J:67965
decreased circulating interleukin-13 level J:67965
decreased IgE level J:67965
decreased interleukin-4 secretion J:67965
decreased interleukin-5 secretion J:67965
decreased interleukin-10 secretion J:67965
decreased T-helper 2 cell number J:67965
increased IgG2b level J:67965
increased IgM level J:67965
increased interferon-gamma secretion J:67965
Il13tm2Anjm/Il13tm2Anjm
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal chemokine level J:131994
abnormal macrophage physiology J:176092
abnormal response to injury J:105813
abnormal susceptibility to infection J:131994
decreased susceptibility to bacterial infection J:176092
decreased susceptibility to parasitic infection J:60609
decreased susceptibility to parasitic infection induced morbidity/mortality J:60609
impaired eosinophil recruitment J:126675
impaired neutrophil recruitment J:105813
Il13tm2Anjm/Il13tm2Anjm
involves: 129P2/OlaHsd * C57BL/6 		abnormal splenocyte physiology J:72587
abnormal T-helper 2 physiology J:89095
decreased susceptibility to parasitic infection induced morbidity/mortality J:60609
normal immune system phenotype J:72587
increased susceptibility to parasitic infection J:89095
Tg(KRT5-tTA)1216Glk/0
Tg(tetO-Il13)1Tazh/0
B6.Cg-Tg(KRT5-tTA)1216Glk Tg(tetO-Il13)1Tazh 		abnormal skin condition J:150232
alopecia J:150232
cutaneous mastocytosis J:150232
dermatitis J:150232
epidermal spongiosis J:150232
hyperkeratosis J:150232
increased angiogenesis J:150232
increased IgE level J:150232
increased IgG1 level J:150232
increased interleukin-4 secretion J:150232
increased interleukin-13 secretion J:150232
increased pruritus J:150232
reddish skin J:150232
skin fibrosis J:150232
skin lesions J:150232
thick dermal layer J:150232
thick epidermis J:150232
Tg(Scgb1a1-Il13)2Eli/?
involves: C57BL/6 * CBA 		abnormal leukocyte physiology J:53612
abnormal pulmonary alveolus morphology J:53612
abnormal pulmonary alveolus wall morphology J:53612
abnormal respiratory system morphology J:53612
abnormal respiratory system physiology J:53612
increased airway resistance J:53612
increased airway responsiveness J:53612
respiratory system inflammation J:53612
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
involves: C57BL/6 * CBA 		abnormal T-helper 2 physiology J:148490
increased T-helper 2 cell number J:148490
pulmonary fibrosis J:148490
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory