Il13^tm1.1Anjm
Targeted Allele Detail

Summary

• Symbol: Il13^tm1.1Anjm
• Name: interleukin 13; targeted mutation 1.1, Andrew NJ McKenzie
• MGI ID: MGI:1931822
• Synonyms: IL-13^-, IL-13^- creed
• Gene: Il13 Location: Chr11:53522151-53525529 bp, - strand Genetic Position: Chr11, 31.98 cM
• Alliance: Il13^tm1.1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67965
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-lacZ cassette was inserted into exon 1. An adjacent loxP flanked neomycin resistance gene was removed in ES cells prior to blastocyst injection, leaving a single loxP site in the final allele. (J:67965)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il13 Mutation: 29 strains or lines available

References

• Original: J:67965 McKenzie GJ, et al., Impaired development of Th2 cells in IL-13-deficient mice. Immunity. 1998 Sep;9(3):423-32
• All: 15 reference(s)