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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
MGI:95808
57 phenotypes from 12 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gria1em1(IMPC)H/Gria1em1(IMPC)H
C57BL/6N-Gria1em1(IMPC)H/H
abnormal freezing behavior J:211773
abnormal gait J:211773
abnormal locomotor behavior J:211773
decreased exploration in new environment J:211773
decreased freezing behavior J:211773
decreased prepulse inhibition J:211773
hyperactivity J:211773
hypoalgesia J:211773
impaired contextual conditioning behavior J:211773
impaired cued conditioning behavior J:211773
increased blood urea nitrogen level J:211773
increased circulating iron level J:211773
increased circulating serum albumin level J:211773
increased mechanical nociceptive threshold J:211773
Gria1em1(IMPC)Hmgu/Gria1em1(IMPC)Hmgu
C57BL/6N-Gria1em1(IMPC)Hmgu/Ieg
decreased bone mineral content J:211773
decreased prepulse inhibition J:211773
decreased startle reflex J:211773
decreased vertical activity J:211773
hyperactivity J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating amylase level J:211773
Gria1tm1Erk/Gria1tm1Erk
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal locomotor behavior J:101930
abnormal response to new environment J:75498
abnormal sexual interaction J:101930
abnormal social investigation J:101930
normal behavior/neurological phenotype J:75498
decreased aggression towards male mice J:101930
normal homeostasis/metabolism phenotype J:75498, J:101930
hyperactivity J:75498
increased vertical activity J:101930
Gria1tm1Lex/Gria1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6
decreased glycosylated hemoglobin level J:82809
increased blood urea nitrogen level J:82809
increased locomotor activity J:82809
Gria1tm1Rlh/Gria1tm1Rlh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal associative learning J:135196
abnormal long-term spatial reference memory J:82443
absent long-term depression J:82443
reduced long-term potentiation J:82443
Gria1tm1Rsp/Gria1tm1Rsp
B6.129-Gria1tm1Rsp
abnormal nociception after inflammation J:96597
abnormal spinal cord morphology J:96597
decreased chemical nociceptive threshold J:96597
impaired synaptic plasticity J:96597
increased anxiety-related response J:167264
reduced AMPA-mediated synaptic currents J:96597
Gria1tm1Rsp/Gria1tm1Rsp
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal behavioral response to xenobiotic J:75498
abnormal locomotor behavior J:75498, J:101930
abnormal response to new environment J:75498
abnormal serotonin level J:101930
abnormal sexual interaction J:101930
abnormal social investigation J:101930
normal behavior/neurological phenotype J:55695
decreased aggression towards male mice J:101930
decreased anxiety-related response J:101930
decreased behavioral withdrawal response J:75498
decreased body size J:55695
normal homeostasis/metabolism phenotype J:75498, J:101930
hyperactivity J:75498
increased exploration in new environment J:101930
increased vertical activity J:101930
normal nervous system phenotype J:55695
reduced AMPA-mediated synaptic currents J:55695
reduced long-term potentiation J:55695
Gria1tm1Rsp/Gria1tm1Rsp
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal emotion/affect behavior J:167264
Gria1tm1Rsp/Gria1tm1Rsp
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
abnormal emotion/affect behavior J:167264
normal homeostasis/metabolism phenotype J:167264
hyperactivity J:167264
increased exploration in new environment J:167264
induced hyperactivity J:167264
Gria1tm2Rlh/Gria1tm2Rlh
B6.Cg-Gria1tm2Rlh
abnormal dendrite morphology J:141127
Gria1tm2Rlh/Gria1tm2Rlh
involves: 129 * C57BL/6
normal nervous system phenotype J:101578
Gria1tm2Rsp/Gria1tm2Rsp
involves: 129S1/Sv * 129X1/SvJ
abnormal miniature excitatory postsynaptic currents J:197912
Gria1tm2Rsp/Gria1tm2Rsp
Tg(Pvalb-cre)1Mony/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal excitatory postsynaptic potential J:136763
abnormal nervous system electrophysiology J:136763
abnormal spatial working memory J:136763
normal behavior/neurological phenotype J:136763
impaired ability to fire action potentials J:136763
reduced AMPA-mediated synaptic currents J:136763
Gria1tm2Rsp/Gria1tm2Rsp
Tg(Slc6a3-icre)9075Gsc/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
abnormal glutamate-mediated receptor currents J:139693
enhanced conditioned place preference behavior J:139693
Gria1tm4Rlh/Gria1tm4Rlh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
absent long-term depression J:126784
Gria1tm5Rlh/Gria1tm5Rlh
involves: 129 * C57BL/6
abnormal associative learning J:135196
Gria1tm6Rlh/Gria1tm6Rlh
involves: 129 * C57BL/6
no abnormal phenotype detected J:135196
Gria1tm7Rlh/Gria1tm7Rlh
involves: 129S6/SvEvTac * C57BL/6
abnormal long-term potentiation J:172128
normal nervous system phenotype J:172128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory