Amhr2tm3(cre)Bhr/Amhr2+
Smad4tm1Rob/Smad4tm1.1Rob
involves: 129S/SvEv * C57BL/6J
|
abnormal cumulus expansion |
J:108954
|
|
abnormal granulosa cell morphology |
J:108954
|
|
abnormal ovarian follicle morphology |
J:108954
|
|
abnormal ovarian folliculogenesis |
J:108954
|
|
abnormal secondary ovarian follicle morphology |
J:108954
|
|
absent cumulus expansion |
J:108954
|
|
decreased litter size |
J:108954
|
|
decreased oocyte number |
J:108954
|
|
decreased ovulation rate |
J:108954
|
|
decreased tertiary ovarian follicle number |
J:108954
|
|
increased circulating progesterone level |
J:108954
|
|
increased secondary ovarian follicle number |
J:108954
|
|
infertility |
J:108954
|
Bmp7tm6(cre)Rob/Bmp7+
Smad4tm1Rob/Smad4tm1.1Rob
involves: 129S/SvEv * C57BL/6 * SJL
|
abnormal kidney development |
J:108109
|
|
abnormal renal glomerulus morphology |
J:108109
|
|
decreased kidney collecting duct number |
J:108109
|
|
hydroureter |
J:108109
|
|
kidney cyst |
J:108109
|
|
perinatal lethality, incomplete penetrance |
J:108109
|
|
postnatal lethality, complete penetrance |
J:108109
|
|
small kidney |
J:108109
|
Ptf1atm1.1(cre)Cvw/Ptf1a+
Smad4tm1Rdp/Smad4tm1Rdp
involves: 129 * FVB/N
|
normal
endocrine/exocrine gland phenotype |
J:116130
|
Smad4E6sad/Smad4+
B6.129P2-Smad4E6sad
|
colon polyps |
J:107273
|
|
decreased tumor-free survival time |
J:107273
|
|
gastric polyps |
J:107273
|
|
intestine polyps |
J:107273
|
Smad4E6sad/Smad4+
involves: 129P2/OlaHsd * C57BL/6
|
increased intestinal adenoma incidence |
J:81488
|
|
increased stomach tumor incidence |
J:81488
|
|
stomach epithelial hyperplasia |
J:81488
|
Smad4E6sad/Smad4E6sad
involves: 129P2/OlaHsd * C57BL/6
|
embryonic growth retardation |
J:81488
|
|
prenatal lethality, complete penetrance |
J:81488
|
Smad4m1Mag/Smad4m1Mag
either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
|
no abnormal phenotype detected |
J:80520
|
Smad4m1Mag/Smad4tm1Cxd
either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
|
no abnormal phenotype detected |
J:80520
|
Smad4m2Mag/Smad4m2Mag
either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
|
no abnormal phenotype detected |
J:80520
|
Smad4m2Mag/Smad4tm1Cxd
either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
|
no abnormal phenotype detected |
J:80520
|
Smad4m3Mag/Smad4m3Mag
either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
|
no abnormal phenotype detected |
J:80520
|
Smad4m3Mag/Smad4tm1Cxd
either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
|
no abnormal phenotype detected |
J:80520
|
Smad4m4Mag/Smad4+
involves: 129S/Sv * Black Swiss * C57BL/6
|
abnormal cecum morphology |
J:106440
|
|
abnormal duodenum morphology |
J:106440
|
|
abnormal large intestine morphology |
J:106440
|
|
abnormal small intestine morphology |
J:106440
|
|
abnormal stomach glandular epithelium morphology |
J:106440
|
|
disorganized stomach mucosa |
J:106440
|
|
gastric polyps |
J:106440
|
|
increased lung tumor incidence |
J:106440
|
|
increased ovary tumor incidence |
J:106440
|
|
increased stomach tumor incidence |
J:106440
|
|
increased tumor incidence |
J:106440
|
Smad4m4Mag/Smad4m4Mag
either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)
|
absent mesoderm |
J:80520
|
|
embryonic growth retardation |
J:80520
|
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:80520
|
|
failure to gastrulate |
J:80520
|
Smad4m4Mag/Smad4tm1Cxd
either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
|
absent mesoderm |
J:80520
|
|
embryonic growth retardation |
J:80520
|
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:80520
|
|
failure to gastrulate |
J:80520
|
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ
|
normal
endocrine/exocrine gland phenotype |
J:229184
|
Smad4tm1.1Rob/Smad4+
involves: 129S/SvEv * CD-1
|
increased stomach tumor incidence |
J:92066
|
Smad4tm1.1Rob/Smad4tm1.1Rob
involves: 129S/SvEv * CD-1
|
abnormal embryonic epiblast morphology |
J:92066
|
|
abnormal endoderm development |
J:92066
|
|
abnormal proximal-distal axis patterning |
J:92066
|
|
abnormal visceral endoderm morphology |
J:92066
|
Smad4tm1.1Rob/Smad4tm2.1Rob
involves: 129S/SvEv * C57BL/6
|
no abnormal phenotype detected |
J:141589
|
Smad4tm1Cxd/Smad4+
involves: 129S6/SvEvTac
|
no abnormal phenotype detected |
J:46852
|
Smad4tm1Cxd/Smad4tm1Cxd
involves: 129S6/SvEvTac
|
abnormal embryonic tissue morphology |
J:46852
|
|
abnormal embryonic-extraembryonic boundary morphology |
J:46852
|
|
abnormal endoderm development |
J:46852
|
|
abnormal extraembryonic tissue morphology |
J:46852
|
|
absent egg cylinders |
J:46852
|
|
absent mesoderm |
J:46852
|
|
decreased cell proliferation |
J:46852
|
|
decreased embryo size |
J:46852
|
|
decreased embryonic epiblast cell proliferation |
J:46852
|
|
decreased inner cell mass proliferation |
J:46852
|
|
embryonic growth arrest |
J:46852
|
|
embryonic lethality between implantation and somite formation, incomplete penetrance |
J:46852
|
|
embryonic lethality between somite formation and embryo turning, incomplete penetrance |
J:46852
|
|
failure of primitive streak formation |
J:46852
|
|
increased Reichert's membrane thickness |
J:46852
|
|
small ectoplacental cone |
J:46852
|
Smad4tm1Mak/Smad4tm1Mak
either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * CD-1)
|
abnormal ectoderm development |
J:45399
|
|
abnormal embryonic tissue morphology |
J:45399
|
|
abnormal embryonic-extraembryonic boundary morphology |
J:45399
|
|
abnormal mesoderm development |
J:45399
|
|
abnormal visceral endoderm morphology |
J:45399
|
|
absent mesoderm |
J:45399
|
|
decreased cell proliferation |
J:45399
|
|
decreased embryo size |
J:45399
|
|
disorganized extraembryonic tissue |
J:45399
|
|
embryonic growth arrest |
J:45399
|
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:45399
|
|
failure of primitive streak formation |
J:45399
|
|
failure to gastrulate |
J:45399
|
|
rostral body truncation |
J:45399
|
Smad4tm1Mmt/Smad4+
B6.129S2-Smad4tm1Mmt
|
duodenum polyps |
J:59214
|
|
gastric polyps |
J:59214
|
Smad4tm1Mmt/Smad4tm1Mmt
involves: 129S2/SvPas * C57BL/6
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:46242
|
Smad4tm1Rdp/Smad4tm1.1Rdp
Tg(CAG-cre)13Miya/0
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL
|
abnormal embryo development |
J:163858
|
|
absent anterior visceral endoderm |
J:163858
|
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N
|
duodenum polyps |
J:116130
|
|
normal
endocrine/exocrine gland phenotype |
J:116130
|
Smad4tm1Rob/Smad4tm1.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * CD-1
|
abnormal allantois morphology |
J:92066
|
|
abnormal dorsal-ventral axis patterning |
J:92066
|
|
abnormal hindbrain development |
J:92066
|
|
abnormal rhombomere morphology |
J:92066
|
|
abnormal rostral-caudal axis patterning |
J:92066
|
|
absent foregut |
J:92066
|
|
absent hindgut |
J:92066
|
|
absent primordial germ cells |
J:92066
|
|
embryonic lethality during organogenesis, complete penetrance |
J:92066
|
|
fused somites |
J:92066
|
Smad4tm1Rob/Smad4tm1.1Rob
Tg(Hoxb7-cre)1Rob/0
involves: 129S/SvEv
|
premature death |
J:108109
|
|
normal
renal/urinary system phenotype |
J:108109
|
Smad4tm2.1Cxd/Smad4+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
increased compact bone thickness |
J:211171
|
|
malocclusion |
J:211171
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Kdrtm1(cre)Sato/Kdr+
involves: 129S1/Sv * 129S6/SvEvTac
|
abnormal embryonic hematopoiesis |
J:112269
|
|
abnormal trabecula carnea morphology |
J:112269
|
|
abnormal vitelline vasculature morphology |
J:112269
|
|
absent atrioventricular cushions |
J:112269
|
|
embryonic lethality during organogenesis, complete penetrance |
J:112269
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(ACTA1-cre)AMcle/0
involves: 129S6/SvEvTac * C57BL/6
|
abnormal heart right ventricle morphology |
J:164492
|
|
abnormal heart ventricle outflow tract morphology |
J:164492
|
|
abnormal trabecula carnea morphology |
J:164492
|
|
double outlet right ventricle |
J:164492
|
|
embryonic lethality during organogenesis, incomplete penetrance |
J:164492
|
|
prenatal lethality, complete penetrance |
J:164492
|
|
thin ventricle myocardium compact layer |
J:164492
|
|
ventricular septal defect |
J:164492
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Capn8-cre)1Xya/0
involves: 129S6/SvEvTac * FVB/N
|
normal
digestive/alimentary phenotype |
J:153563
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Dppa3-cre/Esr1*)3Sait/0
involves: 129S6/SvEvTac * C57BL/6 * DBA
|
abnormal male meiosis |
J:191052
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Foxn1-cre)8Ghr/0
B6.Cg-Smad4tm2.1Cxd Tg(Foxn1-cre)8Ghr
|
abnormal thymus physiology |
J:138837
|
|
small thymus |
J:138837
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Krt1-15-cre/PGR*)22Cot/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
|
abnormal hair growth |
J:203922
|
|
enlarged sebaceous gland |
J:203922
|
|
hair follicle degeneration |
J:203922
|
|
normal
neoplasm |
J:203922
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(KRT5-cre)1Xya/0
involves: 129S6/SvEvTac
|
abnormal hair follicle morphology |
J:101602
|
|
abnormal hair follicle regression |
J:101602
|
|
abnormal hypodermis morphology |
J:101602
|
|
abnormal keratinocyte morphology |
J:101602
|
|
abnormal keratinocyte physiology |
J:101602
|
|
abnormal skin appearance |
J:101602
|
|
alopecia |
J:101602
|
|
enlarged hair follicles |
J:101602
|
|
hyperkeratosis |
J:101602
|
|
increased carcinoma incidence |
J:101602
|
|
increased keratinocyte proliferation |
J:101602
|
|
increased skin papilloma incidence |
J:101602
|
|
increased skin tumor incidence |
J:101602
|
|
premature death |
J:101602
|
|
thick epidermis |
J:101602
|
|
thick epidermis stratum basale |
J:101602
|
|
thick hair follicle outer root sheath |
J:101602
|
|
thick skin |
J:101602
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Nes-cre)1Atp/0
involves: 129S6/SvEvTac * FVB/N
|
abnormal cerebellar molecular layer |
J:86155
|
|
decreased Purkinje cell number |
J:86155
|
|
embryonic lethality, complete penetrance |
J:86155
|
|
increased vertical activity |
J:86155
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Pou5f1-cre/ERT2)#Ysa/0
involves: 129S6/SvEvTac
|
abnormal male meiosis |
J:191052
|
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S6/SvEvTac * C57BL/6J * CD-1
|
abnormal bone collagen fibril morphology |
J:211171
|
|
abnormal compact bone lamellar structure |
J:211171
|
|
abnormal enamel morphology |
J:211171
|
|
abnormal long bone diaphysis morphology |
J:211171
|
|
abnormal osteoblast physiology |
J:211171
|
|
abnormal osteocyte morphology |
J:211171
|
|
abnormal tibia morphology |
J:211171
|
|
abnormal tooth morphology |
J:211171
|
|
abnormal trabecular bone morphology |
J:211171
|
|
clavicle hypoplasia |
J:211171
|
|
decreased body size |
J:211171
|
|
decreased bone mineral density |
J:211171
|
|
decreased compact bone thickness |
J:211171
|
|
decreased diameter of tibia |
J:211171
|
|
decreased osteoclast cell number |
J:211171
|
|
delayed bone ossification |
J:211171
|
|
malocclusion |
J:211171
|
|
postnatal lethality, incomplete penetrance |
J:211171
|
|
premature death |
J:211171
|
|
rib fractures |
J:211171
|
|
short tibia |
J:211171
|
|
small incisors |
J:211171
|
|
small thoracic cavity |
J:211171
|
Smad4tm2.1Rob/Smad4tm2.1Rob
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CBA)
|
no abnormal phenotype detected |
J:141589
|
Smad4tm2.2Cxd/Smad4tm2.2Cxd
involves: Black Swiss
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:75140
|
Smad4tm2Cxd/Smad4tm2Cxd
involves: Black Swiss
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:75140
|
Smad4tm3Rob/Smad4tm3Rob
involves: 129S/SvEv * C57BL/6
|
no abnormal phenotype detected |
J:141589
|
Tg(Amh-Smad4)1Tkw/0
involves: CD-1
|
arrest of spermatogenesis |
J:79698
|
|
azoospermia |
J:79698
|
|
decreased male germ cell number |
J:79698
|
|
decreased testis weight |
J:79698
|
|
normal
homeostasis/metabolism phenotype |
J:79698
|
|
increased circulating testosterone level |
J:79698
|
|
increased Leydig cell number |
J:79698
|
|
increased male germ cell apoptosis |
J:79698
|
|
male infertility |
J:79698
|
|
seminiferous tubule degeneration |
J:79698
|
|
small seminiferous tubules |
J:79698
|
|
small testis |
J:79698
|
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