Tg(ACTA1-cre)AMcle
Transgene Detail

Summary

• Symbol: Tg(ACTA1-cre)AMcle
• Name: transgene insertion A, Ian S McLennan
• MGI ID: MGI:4833970
• Synonyms: MuCr-A, MuCreA, MuCre-A
• Transgene: Tg(ACTA1-cre)AMcle Location: unknown
• Alliance: Tg(ACTA1-cre)AMcle page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(ACTA1-cre)AMcle expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: The human alpha skeletal muscle actin (ACTA1) promoter was used to drive expression of cre recombinase in a transgenic construct. The construct was injected into C57BL/6 zygotes. 14 founders were generated, and two lines were characterized further. Lines A and B were analyzed. Cre expression was observed in skeletal muscle as well as in the heart, with line A exhibiting 40% of the level of cre mRNA detected in skeletal muscle, and line B showing 0.1% of skeletal muscle cre mRNA levels in the heart muscle. (J:164492)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	ACTA1 (human) Summary of all recombinase alleles driven by ACTA1. Alliance human ACTA1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:164492 Azhar M, et al., Myocardial deletion of Smad4 using a novel alpha skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. Int J Biol Sci. 2010;6(6):546-55
• All: 5 reference(s)