Phenotypes associated with this allele

• Allele Symbol: Tg(ACTA1-cre)AMcle
• Allele Name: transgene insertion A, Ian S McLennan
• Allele ID: MGI:4833970
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Smad4^tm2.1Cxd/Smad4^tm2.1Cxd Tg(ACTA1-cre)AMcle/0	involves: 129S6/SvEvTac * C57BL/6	MGI:5297811

Genotype
MGI:5297811

cn1

• Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd; Tg(ACTA1-cre)AMcle/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:164492 )

• significant midgestational lethality occurs between E13.5 and E14.5 with only 2 viable mutant fetuses (and 6 dead) out of 34 recovered at E14.5

• 2 viable fetuses (8 dead) are recovered at E18.5 (2 mutant/50 total)

prenatal lethality, complete penetrance ( J:164492 )

• no live mutants are recovered after birth

cardiovascular system

abnormal trabecula carnea morphology ( J:164492 )

• decreased density of trabeculae in ventricles is observed at E13.5

thin ventricle myocardium compact layer ( J:164492 )

• thinning of compact layer of ventricular myocardium is observed at E13.5

double outlet right ventricle ( J:164492 )

• observed at E13.5; defect is more closely related to aortic orifice in mutants

ventricular septal defect ( J:164492 )

• observed at E13.5, resulting from due to deficiency of mesenchyme in the region where outflow tract and AV cushions should meet

abnormal heart right ventricle morphology ( J:164492 )

• in E13.5 mutatnts, only a small fibrous ridge separates the aortic valve from right ventricular outflow tract, as outlet cushions are proximally not fused

abnormal heart ventricle outflow tract morphology ( J:164492 )

• bifurcated outflow tract is in right ventricle, not over ventricular septum

muscle

abnormal trabecula carnea morphology ( J:164492 )

• decreased density of trabeculae in ventricles is observed at E13.5

thin ventricle myocardium compact layer ( J:164492 )

• thinning of compact layer of ventricular myocardium is observed at E13.5