Smarca4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
MGI:88192

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Rb1^tm1Tyj/Rb1⁺ Smarca4^tm1Mag/Smarca4⁺ involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1	increased pituitary gland tumor incidence	J:132091
	premature death	J:132091
Smarca2^tm1Mya/Smarca2⁺ Smarca4^tm1.2Pcn/Smarca4^tm1.1Pcn Tg(Myh11-cre,-EGFP)2Mik/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal small intestine morphology	J:172661
	decreased colon length	J:172661
	decreased small intestine length	J:172661
	enlarged cecum	J:172661
	megacolon	J:172661
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1.1Pcn/Smarca4⁺ involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal muscle physiology	J:172661
	normal digestive/alimentary phenotype	J:172661
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1.2Pcn/Smarca4^tm1.1Pcn Tg(Myh11-cre,-EGFP)2Mik/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal digestive system morphology	J:172661
	abnormal intestinal smooth muscle morphology	J:172661
	abnormal intestine morphology	J:172661
	abnormal muscle physiology	J:172661
	abnormal small intestine morphology	J:172661
	abnormal urinary bladder morphology	J:172661
	impaired smooth muscle contractility	J:172661
	postnatal lethality, complete penetrance	J:172661
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Tg(KRT14-cre/ERT2)1Ipc/? involves: 129S2/SvPas	abnormal epidermis stratum corneum morphology	J:101729
	abnormal epidermis stratum granulosum morphology	J:101729
	abnormal skin morphology	J:101729
	enlarged spinous cells	J:101729
	impaired skin barrier function	J:101729
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1Mag/Smarca4⁺ involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1	increased hemangiosarcoma incidence	J:132091
	increased mammary gland tumor incidence	J:132091
Smarca4^mos6/Smarca4⁺ Sox10^tm1Weg/Sox10⁺ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	abnormal melanoblast morphology	J:241206
	belly spot	J:241206
	head spot	J:241206
Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	abnormal semilunar valve morphology	J:226941
Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Tg(Lck-cre)1Cwi/0 Tg(LCKprBCL2L1)12Sjk/0 Not Specified	abnormal T cell morphology	J:144072
	decreased double-positive T cell number	J:144072
	increased double-negative T cell number	J:144072
	increased thymocyte number	J:144072
Smarca4^tm1.2Pcn/Smarca4^tm1Mag Tg(Lck-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/? involves: 129S/Sv * C57BL/6 * DBA/2	arrested T cell differentiation	J:85191
Smarca4^tm1.2Pcn/Smarca4^tm1Tich Tg(Lck-cre)1Cwi/0 Tg(LCKprBCL2L1)12Sjk/0 involves: 129	abnormal T cell morphology	J:144072
	decreased double-positive T cell number	J:144072
	increased double-negative T cell number	J:144072
	increased thymocyte number	J:144072

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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