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Smarca4 Gene Detail
Summary
  • Symbol
    Smarca4
  • Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • Synonyms
    b2b508.1Clo, b2b692Clo, Brg1, SNF2beta, SW1/SNF
  • Feature Type
    protein coding gene
  • IDs
    MGI:88192
    NCBI Gene: 20586
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21527465-21615526 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.84 cM
Strain
Comparison
more
  • SNPs within 2kb
    1854 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88192
 protein coding gene Chr9:21527377-21615526 (+)
129S1/SvImJ ENSMUSG00200048852
 protein coding gene Chr9:18481694-18569760 (+)
A/J ENSMUSG00195036768
 protein coding gene Chr9:18318300-18406357 (+)
AKR/J ENSMUSG00220028103
 protein coding gene Chr9:18320743-18408812 (+)
BALB/cJ ENSMUSG00180035204
 protein coding gene Chr9:18452604-18540656 (+)
C3H/HeJ ENSMUSG00175041599
 protein coding gene Chr9:18415157-18503204 (+)
C57BL/6NJ ENSMUSG00215033692
 protein coding gene Chr9:18412442-18500514 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031879
 protein coding gene Chr9:17624689-17717056 (+)
CAST/EiJ ENSTCUG00005032678
 protein coding gene Chr9:18464813-18552946 (+)
CBA/J ENSMUSG00210041914
 protein coding gene Chr9:18396070-18484138 (+)
DBA/2J ENSMUSG00185025569
 protein coding gene Chr9:18511382-18599433 (+)
FVB/NJ ENSMUSG00205040560
 protein coding gene Chr9:18739202-18827171 (+)
JF1/MsJ ENSUMUG00000032381
 protein coding gene Chr9:18619716-18707106 (+)
LP/J ENSMUSG00230039937
 protein coding gene Chr9:18898445-18986408 (+)
NOD/ShiLtJ ENSMUSG00190039254
 protein coding gene Chr9:18432198-18520147 (+)
NZO/HlLtJ ENSMUSG00225047949
 protein coding gene Chr9:18853360-18941430 (+)
PWK/PhJ ENSLUMG00010036828
 protein coding gene Chr9:18509393-18599098 (+)
SPRET/EiJ ENSMSPG00010020928
 protein coding gene Chr9:18741683-18832177 (+)
WSB/EiJ ENSIUOG00005039012
 protein coding gene Chr9:17979893-18067832 (+)



Homology
more
  • Human Ortholog
    SMARCA4, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMARCA4, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
  • Synonyms
    BAF190, BAF190A, BRG1, CSS4, hSNF2b, MRD16, OTSC12, RTPS2, SNF2, SNF2-beta, SNF2L4, SNF2LB, SWI2
  • Links
    NCBI Gene ID: 6597
    UniProt: P51532

  • Chr Location
    19p13.2; chr19:10960824-11079426 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Smarca4 mouse models; 4 with human SMARCA4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    87 phenotypes from 10 alleles in 16 genetic backgrounds
    31 phenotypes from multigenic genotypes
    27 images
    156 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele die in utero before implantation. Embryos heterozygous for this null allele and an ENU-induced allele show impaired definitive erythropoiesis, anemia and lethality during organogenesis. Heterozygotes for a different null allele show cyanosis and cardiovascular defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    219
  • GO References
    77
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1365
  • Tissues
    365
  • cDNA Data
    456
  • Literature Summary
    107
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032187 Ensembl Gene Model | MGI Sequence Detail 88062 C57BL/6J ±  kb
    transcript ENSMUST00000098948 Ensembl | MGI Sequence Detail 6376 Not Applicable  
    polypeptide ENSMUSP00000096547 Ensembl | MGI Sequence Detail 1617 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 473
      Genomic 1
      cDNA 457
      Primer pair 12
      Other 3
      Antibodies 22

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1622, MGI:5313994, MGI:5316763
    References
    more
    • Summaries
      All 423
      Developmental Gene Expression 107
      Diseases 1
      Gene Ontology 77
      Phenotypes 156
    • Earliest
      J:320308 Valka I, et al., Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1. Planta Med. 1985 Aug;51(4):319-22
    • Latest
      J:390322 Wu ML, et al., Plasmin and sterile inflammation jointly drive fatal embryonic liver degeneration in endothelial chromatin remodeler mutant mice. Development. 2026 Aug 15;153(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory