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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
B2m
beta-2 microglobulin
MGI:88127
77 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
B2mtm1Jae/B2mtm1Jae
Cd4tm1.1Yzo/Cd4tm1.1Yzo
involves: 129P2/OlaHsd * 129S2/SvPas
abnormal T cell differentiation J:130559
B2mtm1Jae/B2mtm1Jae
Cd4tm1Jrp/Cd4tm1Jrp
involves: 129S2/SvPas * C57BL/6
increased CD8-positive, alpha-beta T cell number J:45168
B2mtm1Jae/B2mtm1Jae
Cd4tm3.2Litt/Cd4tm3.2Litt
involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N
abnormal T cell differentiation J:158962
abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha beta T cell number J:158962
increased CD8-positive, alpha-beta T cell number J:158962
increased T cell proliferation J:158962
B2mtm1Jae/B2mtm1Jae
Foxp3sfOtcspf/Y
involves: 129/Rl * 129S2/SvPas
abnormal immune system organ morphology J:20865
abnormal interleukin level J:20865
abnormal lymph node morphology J:20865
abnormal tumor necrosis factor level J:20865
anemia J:20865
decreased body size J:20865
decreased hematocrit J:20865
dermatitis J:20865
enlarged lymph nodes J:20865
enlarged spleen J:20865
increased CD4-positive, alpha beta T cell number J:20865
increased IgG level J:20865
increased IgM level J:20865
increased immunoglobulin level J:20865
increased plasma cell number J:20865
B2mtm1Jae/B2mtm1Jae
Tap1tm1Hpl/Tap1tm1Hpl
B6.129-B2mtm1Jae Tap1tm1Hpl
abnormal lateral geniculate nucleus morphology J:66246
abnormal long term depression J:66246
abnormal miniature excitatory postsynaptic currents J:120941
abnormal synapse morphology J:120941
abnormal synaptic bouton morphology J:120941
abnormal synaptic vesicle number J:120941
enhanced long term potentiation J:66246
enlarged lateral ventricles J:66246
reduced long term depression J:66246
B2mtm1Jae/B2mtm1Jae
Tg(H2-K-Cd86)27All/0
involves: 129S2/SvPas * C57BL/6 * CBA
absent B cells J:112475
B2mtm1Jae/B2mtm1Jae
Tg(LckNotch1)9Erob/?
involves: 129S2/SvPas * C57BL/6 * CBA
increased CD8-positive, alpha-beta T cell number J:93005
lymph node hypoplasia J:93005
B2mtm1Jae/B2mtm1Jae
Themistm1Lov/Themistm1Lov
involves: 129
abnormal CD8-positive, alpha-beta T cell differentiation J:151075
B2mtm1Jae/B2mtm1Jae
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
small intestinal inflammation J:108572
B2mtm1Jae/B2mtm1Jae
Toxtm1.1Kay/Toxtm1.1Kay
involves: 129S6/SvEvTac * 129S2/SvPas
abnormal CD8-positive, alpha-beta T cell number J:131287
B2mtm1Jae/B2mtm1Jae
Zbtb7btm1Litt/Zbtb7btm1.2Litt
involves: 129S2/SvPas * C57BL/6
abnormal CD8-positive, alpha-beta T cell differentiation J:141144
abnormal double-positive T cell morphology J:141144
B2mtm1Unc/B2mtm1Unc
Cd4tm1Mak/Cd4tm1Mak
Cd8atm2.1(Cd4)Asin/Cd8atm2.1(Cd4)Asin
involves: 129 * C57BL/6
abnormal T cell physiology J:180236
B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum
NOD.Cg-B2mtm1Unc Ciitatm1Ccum
abnormal glucose homeostasis J:107051
decreased single-positive T cell number J:107051
decreased susceptibility to autoimmune diabetes J:107051
B2mtm1Unc/B2mtm1Unc
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/?
Tg(HLA-A2.1)1Enge/?
NOD.Cg-Prkdcscid Emv30b B2mtm1Unc Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl/Dvs
decreased susceptibility to autoimmune diabetes J:109851
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
involves: 129P2/OlaHsd * 129S2/SvPas
abnormal neuron proliferation J:170591
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Lattm1Mal/Lattm1Mal
involves: 129P2/OlaHsd * 129S2/SvPas
absent CD4-positive, alpha beta T cells J:77098
absent CD8-positive, alpha-beta T cells J:77098
normal immune system phenotype J:77098
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
atrioventricular block J:113267
normal cardiovascular system phenotype J:113267
prolonged PR interval J:113267
B2mtm1Unc/B2mtm1Unc
H2-D1tm1Bpe/H2-D1tm1Bpe
involves: 129P2/OlaHsd * C57BL/6
decreased CD8-positive, alpha-beta T cell number J:41077
B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca
involves: 129S6/SvEvTac * C57BL/6J
increased liver iron level J:62112
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129 * C57BL/6
abnormal CD4-positive T cell differentiation J:39981
abnormal CD4-positive, alpha-beta T cell physiology J:51450
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology J:39981
abnormal CD8-positive, alpha beta T cell morphology J:51450
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:39981
cachexia J:39981, J:51450
colitis J:39981, J:51450
diarrhea J:39981, J:51450
increased intestinal adenocarcinoma incidence J:51450
rectal prolapse J:51450
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129P2/OlaHsd
normal reproductive system phenotype J:134589
B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)#Asin/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
decreased CD8-positive, alpha-beta T cell number J:190889
B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)#Asin/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
decreased CD8-positive, alpha-beta T cell number J:190889
B2mtm1Unc/B2mtm1Unc
Irf2tm1Mak/Irf2tm1Mak
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
abnormal skin condition J:66034
B2mtm1Unc/B2mtm1Unc
Lattm1Mal/Lattm1Mal
involves: 129P2/OlaHsd * 129S2/SvPas
abnormal immune system morphology J:77098
B2mtm1Unc/B2mtm1Unc
Prkdcscid/Prkdcscid
NOD.Cg-B2mtm1Unc Prkdcscid
abnormal NK cell physiology J:102141
abnormal response to transplant J:102141
absent lymphocyte J:102141
arrested B cell differentiation J:102141
arrested T cell differentiation J:102141
decreased level of surface class I molecules J:102141
increased liver iron level J:102141
increased macrophage cell number J:102141
increased T cell derived lymphoma incidence J:102141
premature death J:102141
B2mtm1Unc/B2mtm1Unc
Tbptm1.1Ees/Tbptm1.1Ees
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
embryonic lethality during organogenesis, incomplete penetrance J:77714
B2mtm1Unc/B2mtm1Unc
Tespa1tm1Lrgl/Tespa1tm1Lrgl
involves: 129 * 129P2/OlaHsd * C57BL/6
abnormal CD8-positive, alpha beta T cell morphology J:186446
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/0
NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs
decreased susceptibility to autoimmune diabetes J:71837
normal endocrine/exocrine gland phenotype J:71837
normal immune system phenotype J:71837
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/Tg(B2M)55Hpl
Tg(HLA-A2.1)1Enge/Tg(HLA-A2.1)1Enge
NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl Tg(HLA-A2.1)1Enge
increased susceptibility to autoimmune diabetes J:109851
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs
abnormal CD8-positive, alpha-beta T cell physiology J:121685
abnormal cell-mediated immunity J:121685
abnormal cytotoxic T cell physiology J:121685
decreased CD8-positive, alpha-beta T cell number J:121685
increased susceptibility to autoimmune diabetes J:121685
B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
abnormal CD8-positive, alpha beta T cell morphology J:93553
decreased susceptibility to autoimmune diabetes J:93553
B2mtm1Unc/B2mtm1Unc
Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
involves: 129P2/OlaHsd
increased CD8-positive, alpha-beta T cell number J:193321
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/0
Tg(HLA-A2.1)1Enge/0
NOD.Cg-Prkdcscid Tg(B2M)55Hpl Tg(HLA-A2.1)1Enge/Sz
abnormal response to transplant J:91764
increased circulating glucose level J:91764
Tg(B2M)55Hpl/?
Tg(CD8aCD8b)57Scr/?
Tg(HLA-B)22Hpl/?
involves: C57BL/6 * C57BL/LiA * CBA
abnormal cytotoxic T cell physiology J:127813
Tg(B2M,HLA-B*27:05)56-3Trg/0
involves: C57BL/6 * SJL/J
normal immune system phenotype J:74451
Tg(H2-K-HLA-G,B2M)1Alm/0
CBA/Ca-Tg(H2-K-HLA-G,B2M)1Alm/CmwJ
abnormal cytotoxic T cell physiology J:140016
increased T cell proliferation J:140016
Tg(HLA-A/H2-D/B2M)1Dvs/0
NOD/ShiLtDvs-Tg(HLA-A/H2-D/B2M)1Dvs
increased susceptibility to autoimmune diabetes J:121685

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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory