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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		B2m
beta-2 microglobulin
MGI:88127
78 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
B2mtm1Jae/B2mtm1Jae
Cd4tm1Jrp/Cd4tm1Jrp
involves: 129S2/SvPas * C57BL/6 		increased CD8-positive, alpha-beta T cell number J:45168
B2mtm1Jae/B2mtm1Jae
Foxp3sfOtcspf/Y
involves: 129/Rl * 129S2/SvPas 		abnormal immune system organ morphology J:20865
abnormal interleukin level J:20865
abnormal lymph node morphology J:20865
abnormal tumor necrosis factor level J:20865
anemia J:20865
decreased body size J:20865
decreased hematocrit J:20865
dermatitis J:20865
enlarged lymph nodes J:20865
enlarged spleen J:20865
increased CD4-positive, alpha-beta T cell number J:20865
increased IgG level J:20865
increased IgM level J:20865
increased immunoglobulin level J:20865
increased plasma cell number J:20865
B2mtm1Jae/B2mtm1Jae
Rr94tm3.2Litt/Rr94tm3.2Litt
involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N 		abnormal T cell differentiation J:158962
abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha-beta T cell number J:158962
increased CD8-positive, alpha-beta T cell number J:158962
increased T cell proliferation J:158962
B2mtm1Jae/B2mtm1Jae
Rr96tm1.1Yzo/Rr96tm1.1Yzo
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal T cell differentiation J:130559
B2mtm1Jae/B2mtm1Jae
Tap1tm1Hpl/Tap1tm1Hpl
B6.129-B2mtm1Jae Tap1tm1Hpl 		abnormal lateral geniculate nucleus morphology J:66246
abnormal long-term depression J:66246
abnormal miniature excitatory postsynaptic currents J:120941
abnormal synapse morphology J:120941
abnormal synaptic bouton morphology J:120941
abnormal synaptic vesicle number J:120941
enhanced long-term potentiation J:66246
enlarged lateral ventricles J:66246
reduced long-term depression J:66246
B2mtm1Jae/B2mtm1Jae
Tg(H2-K-Cd86)27All/0
involves: 129S2/SvPas * C57BL/6 * CBA 		absent B cells J:112475
B2mtm1Jae/B2mtm1Jae
Tg(LckNotch1)9Erob/?
involves: 129S2/SvPas * C57BL/6 * CBA 		increased CD8-positive, alpha-beta T cell number J:93005
lymph node hypoplasia J:93005
B2mtm1Jae/B2mtm1Jae
Themistm1Lov/Themistm1Lov
involves: 129 		abnormal CD8-positive, alpha-beta T cell differentiation J:151075
B2mtm1Jae/B2mtm1Jae
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J 		small intestinal inflammation J:108572
B2mtm1Jae/B2mtm1Jae
Toxtm1.1Kay/Toxtm1.1Kay
involves: 129S6/SvEvTac * 129S2/SvPas 		abnormal CD8-positive, alpha-beta T cell number J:131287
B2mtm1Jae/B2mtm1Jae
Zbtb7btm1Litt/Zbtb7btm1.2Litt
involves: 129S2/SvPas * C57BL/6 		abnormal CD8-positive, alpha-beta T cell differentiation J:141144
abnormal double-positive T cell morphology J:141144
B2mtm1Unc/B2mtm1Unc
Cd4tm1Mak/Cd4tm1Mak
Cd8atm2.1(Cd4)Asin/Cd8atm2.1(Cd4)Asin
involves: 129 * C57BL/6 		abnormal T cell physiology J:180236
B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum
NOD.Cg-B2mtm1Unc Ciitatm1Ccum 		abnormal glucose homeostasis J:107051
decreased single-positive T cell number J:107051
decreased susceptibility to autoimmune diabetes J:107051
B2mtm1Unc/B2mtm1Unc
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/?
Mcph1Tg(HLA-A2.1)1Enge/?
NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs 		decreased susceptibility to autoimmune diabetes J:109851
B2mtm1Unc/B2mtm1Unc
H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal neuron proliferation J:170591
B2mtm1Unc/B2mtm1Unc
H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi
Lattm1.1Mal/Lattm1.1Mal
involves: 129P2/OlaHsd * 129S2/SvPas 		absent CD4-positive, alpha-beta T cells J:77098
absent CD8-positive, alpha-beta T cells J:77098
normal immune system phenotype J:77098
B2mtm1Unc/B2mtm1Unc
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-B2mtm1Unc H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell 		atrioventricular block J:113267
normal cardiovascular system phenotype J:113267
prolonged PR interval J:113267
B2mtm1Unc/B2mtm1Unc
H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
involves: 129P2/OlaHsd * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:41077
B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca
involves: 129S6/SvEvTac * C57BL/6J 		increased liver iron level J:62112
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129 * C57BL/6 		abnormal CD4-positive T cell differentiation J:39981
abnormal CD4-positive, alpha-beta T cell physiology J:51450
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology J:39981
abnormal CD8-positive, alpha beta T cell morphology J:51450
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:39981
cachexia J:39981, J:51450
colitis J:39981, J:51450
diarrhea J:39981, J:51450
increased intestinal adenocarcinoma incidence J:51450
rectal prolapse J:51450
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129P2/OlaHsd 		normal reproductive system phenotype J:134589
B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:190889
B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:190889
B2mtm1Unc/B2mtm1Unc
Irf2tm1Mak/Irf2tm1Mak
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal skin condition J:66034
B2mtm1Unc/B2mtm1Unc
Lattm1.1Mal/Lattm1.1Mal
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal immune system morphology J:77098
B2mtm1Unc/B2mtm1Unc
Prkdcscid/Prkdcscid
NOD.Cg-B2mtm1Unc Prkdcscid 		abnormal NK cell physiology J:102141
abnormal response to transplant J:102141
absent lymphocyte J:102141
arrested B cell differentiation J:102141
arrested T cell differentiation J:102141
decreased level of surface class I molecules J:102141
increased liver iron level J:102141
increased macrophage cell number J:102141
increased T cell derived lymphoma incidence J:102141
premature death J:102141
B2mtm1Unc/B2mtm1Unc
Rr381em2Kap/Rr381em2Kap
involves: 129P2/OlaHsd * C57BL/6 		absent CD8-positive, alpha-beta T cells J:333471
B2mtm1Unc/B2mtm1Unc
Tbptm1.1Ees/Tbptm1.1Ees
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		embryonic lethality during organogenesis, incomplete penetrance J:77714
B2mtm1Unc/B2mtm1Unc
Tespa1tm1Smoc/Tespa1tm1Smoc
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal CD8-positive, alpha beta T cell morphology J:186446
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/0
NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs 		decreased susceptibility to autoimmune diabetes J:71837
normal endocrine/exocrine gland phenotype J:71837
normal immune system phenotype J:71837
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/Tg(B2M)55Hpl
Mcph1Tg(HLA-A2.1)1Enge/Mcph1Tg(HLA-A2.1)1Enge
NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl 		increased susceptibility to autoimmune diabetes J:109851
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs 		abnormal CD8-positive, alpha-beta T cell physiology J:121685
abnormal cell-mediated immunity J:121685
abnormal cytotoxic T cell physiology J:121685
decreased CD8-positive, alpha-beta T cell number J:121685
increased susceptibility to autoimmune diabetes J:121685
B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs 		abnormal CD8-positive, alpha beta T cell morphology J:93553
decreased susceptibility to autoimmune diabetes J:93553
B2mtm1Unc/B2mtm1Unc
X/Yaa
BXSB.129P2(B6)-B2mtm1Unc/Dcr 		increased anti-nuclear antigen antibody level J:179430
increased susceptibility to systemic lupus erythematosus J:179430
premature death J:179430
B2mtm1Unc/B2mtm1Unc
Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
involves: 129P2/OlaHsd 		increased CD8-positive, alpha-beta T cell number J:193321
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory