Cd4^tm1Jrp
Targeted Allele Detail

Summary

• Symbol: Cd4^tm1Jrp
• Name: CD4 antigen; targeted mutation 1, Jane R Parnes
• MGI ID: MGI:3639344
• Synonyms: Cd4^low
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^tm1Jrp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45168
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 10, 3' to the coding sequences of the gene. This allele expresses a twofold lower level of the encoded protein in the thymus and thus behaves as a hypomorph. (J:45168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 82 strains or lines available

References

• Original: J:45168 Frank GD, et al., The level of CD4 surface protein influences T cell selection in the thymus. J Immunol. 1998 Jan 15;160(2):634-42
• All: 1 reference(s)