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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Atg7
autophagy related 7
MGI:1921494
91 phenotypes from 2 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Atg7tm1.1Tchi/Atg7tm1.1Tchi
involves: C57BL/6 * CBA * FVB/N
abnormal cell morphology J:100199
abnormal circulating amino acid level J:100199
decreased body weight J:100199
neonatal lethality, complete penetrance J:100199
Atg7tm1Tchi/Atg7tm1Tchi
Aviltm2(cre)Fawa/Avil+
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal sensory neuron morphology J:160568
bradykinesia J:160568
curly tail J:160568
gliosis J:160568
increased neuron apoptosis J:160568
limb grasping J:160568
neurodegeneration J:160568
tremors J:160568
Atg7tm1Tchi/Atg7tm1Tchi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
abnormal common lymphocyte progenitor cell morphology J:176843
abnormal hematopoietic stem cell morphology J:176843
abnormal hematopoietic stem cell physiology J:176843
abnormal leukocyte morphology J:176843
decreased B cell number J:176843
decreased bone marrow cell number J:176843
decreased common myeloid progenitor cell number J:176843
decreased hematopoietic stem cell number J:176843
decreased leukocyte cell number J:176843
decreased NK cell number J:176843
decreased T cell number J:176843
Atg7tm1Tchi/Atg7tm1Tchi
En1tm2(cre)Wrst/En1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
abnormal brain morphology J:192452
abnormal gait J:192452
abnormal locomotor behavior J:192452
abnormal neuron morphology J:192452
abnormal substantia nigra pars compacta morphology J:192452
astrocytosis J:192452
ataxia J:192452
decreased dopamine level J:192452
decreased survivor rate J:192452
neuron degeneration J:192452
premature death J:192452
Purkinje cell degeneration J:192452
tremors J:192452
weight loss J:192452
Atg7tm1Tchi/Atg7tm1Tchi
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
abnormal circulating chemokine level J:235399
abnormal kidney morphology J:235399
abnormal macrophage physiology J:235399
abnormal renal glomerulus morphology J:235399
decreased body weight J:235399
decreased circulating interleukin-10 level J:235399
glomerulonephritis J:235399
increased anti-double stranded DNA antibody level J:235399
increased anti-nuclear antigen antibody level J:235399
increased autoantibody level J:235399
increased blood urea nitrogen level J:235399
increased circulating creatinine level J:235399
increased circulating interleukin-1 beta level J:235399
increased circulating interleukin-6 level J:235399
increased circulating interleukin-12b level J:235399
increased IgG level J:235399
increased lymphocyte cell number J:235399
increased monocyte cell number J:235399
increased neutrophil cell number J:235399
increased susceptibility to systemic lupus erythematosus J:235399
increased urine protein level J:235399
Atg7tm1Tchi/Atg7tm1Tchi
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
abnormal neuron morphology J:192452
abnormal substantia nigra pars compacta morphology J:192452
decreased dopamine level J:192452
hyperactivity J:192452
neuron degeneration J:192452
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Camk2a-cre)T29-1Stl/0
involves: BALB/c * C57BL * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
abnormal dendritic spine morphology J:217829
abnormal response to social novelty J:217829
abnormal social investigation J:217829
impaired autophagy J:217829
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA
abnormal amino acid level J:100199
abnormal circulating enzyme level J:100199
abnormal hepatocyte morphology J:100199, J:130839
abnormal liver morphology J:100199
abnormal liver physiology J:100199
decreased liver function J:130839
enlarged liver J:100199
impaired autophagy J:130839
increased circulating alanine transaminase level J:100199, J:130839
increased circulating alkaline phosphatase level J:100199, J:130839
increased circulating aspartate transaminase level J:100199, J:130839
increased hepatocyte proliferation J:130839
increased liver weight J:100199, J:130839
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Nes-cre)1Wme/0
involves: C57BL/6 * CBA
abnormal nervous system physiology J:130839
absent cerebral cortex pyramidal cells J:130839
absent hippocampus pyramidal cells J:130839
axon degeneration J:130839
impaired autophagy J:130839
increased neuron apoptosis J:130839
limb grasping J:130839
tremors J:130839
Atg7tm1Tchi/Atg7tm1Tchi
Tg(SLC18A3-cre)KMisa/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
abnormal motor neuron morphology J:193770
normal behavior/neurological phenotype J:193770
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Tyr-cre)1Lru/Y
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
abnormal autophagy J:220623
abnormal coat/hair pigmentation J:220623
abnormal epidermal melanocyte morphology J:220623
abnormal epidermal pigmentation J:220623
abnormal melanocyte proliferation J:220623
abnormal melanosome morphology J:220623
decreased foot pigmentation J:220623
decreased tail pigmentation J:220623
dilated mitochondria J:220623
early cellular replicative senescence J:220623
oxidative stress J:220623
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Vil1-cre)1000Gum/0
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * SJL/J
abnormal intestinal goblet cell morphology J:206181

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory