156 phenotypes from 17 alleles in 20 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxp3m1Btlr/Y C57BL/6J-Foxp3m1Btlr	abnormal reproductive system development	J:141212
	alopecia	J:141212
	azoospermia	J:141212
	decreased body size	J:141212
	dry skin	J:141212
	premature death	J:141212
	scaly skin	J:141212
	skin lesions	J:141212
Foxp3m1Btlr/Foxp3+ C57BL/6J-Foxp3m1Btlr	no abnormal phenotype detected	J:141212
Foxp3m1Btlr/Foxp3m1Btlr C57BL/6J-Foxp3m1Btlr	normal mortality/aging	J:141212
Foxp3sf/Y B6.Cg-Foxp3sf	abnormal CD4-positive, alpha beta T cell morphology	J:82560
	abnormal CD4-positive, alpha-beta T cell physiology	J:82560
	abnormal homeostasis	J:167802
	abnormal megakaryocyte progenitor cell morphology	J:167802
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:82560
	decreased megakaryocyte cell number	J:167802
	increased mean platelet volume	J:167802
	thrombocytopenia	J:167802
Foxp3sf/Y B6.Cg-Foxp3sf/J	lung inflammation	J:125129
	salivary gland inflammation	J:125129
	skin inflammation	J:125129
Foxp3sf/Y either: 129Rl.Cg-Foxp3sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)	abnormal atrial thrombosis	J:11262
	abnormal B cell physiology	J:11262
	abnormal epidermal layer morphology	J:11262
	abnormal erythrocyte morphology	J:11262
	abnormal hepatic cord morphology	J:11262
	abnormal liver morphology	J:11262
	abnormal lymph node B cell domain morphology	J:11262
	abnormal lymph node medullary cord morphology	J:11262
	abnormal lymph node morphology	J:11262
	abnormal lymph node T cell domain morphology	J:11262
	abnormal lymphocyte morphology	J:11262
	abnormal macrophage morphology	J:11262
	abnormal male reproductive system morphology	J:11262
	abnormal spleen morphology	J:11262
	abnormal spleen white pulp morphology	J:11262
	abnormal tail ring morphology	J:11262
	abnormal thymus cortex morphology	J:11262
	abnormal thymus morphology	J:11262
	absent spleen marginal zone	J:11262
	anemia	J:11262
	anisocytosis	J:11262
	blepharitis	J:11262
	cachexia	J:11262
	cryptorchism	J:11262
	decreased body size	J:11262
	decreased hematocrit	J:11262
	decreased hemoglobin content	J:11262
	decreased spleen B cell follicle number	J:11262
	dermatitis	J:11262
	dilated liver sinusoidal space	J:11262
	distended abdomen	J:11262
	enlarged heart	J:11262
	enlarged liver	J:11262
	enlarged lymph nodes	J:11262
	epidermal hyperplasia	J:11262
	extramedullary hematopoiesis	J:11262
	hemosiderosis	J:11262
	hunched posture	J:11262
	increased IgG level	J:11262
	increased IgM level	J:11262
	increased inflammatory response	J:11262
	increased leukocyte cell number	J:11262
	increased mean corpuscular volume	J:11262
	increased spleen red pulp amount	J:11262
	increased spleen weight	J:11262
	jaundice	J:11262
	liver inflammation	J:11262
	multifocal hepatic necrosis	J:11262
	orthokeratosis	J:11262
	pale kidney	J:11262
	parakeratosis	J:11262
	pleural effusion	J:11262
	poikilocytosis	J:11262
	polychromatophilia	J:11262
	premature death	J:11262
	scaly ears	J:11262
	scaly skin	J:11262
	skin lesions	J:11262
	small ears	J:11262
	small testis	J:11262
	small thymus	J:11262
	thick ears	J:11262
Foxp3sf/Y involves: 101/H * C3H/HeH * STOCK MR	abnormal breathing pattern	J:10398
	abnormal erythrocyte morphology	J:10398
	abnormal liver morphology	J:10398
	abnormal male reproductive system morphology	J:10398
	abnormal reticulocyte morphology	J:10398
	abnormal spleen morphology	J:10398
	absent scrotum	J:10398
	anemia	J:10398
	conjunctivitis	J:10398
	cryptorchism	J:10398
	decreased body size	J:10398
	decreased body weight	J:10398
	decreased erythrocyte cell number	J:10398
	decreased hematocrit	J:10398
	decreased hemoglobin content	J:10398
	decreased megakaryocyte cell number	J:10398
	diarrhea	J:10398
	enlarged liver	J:10398
	extramedullary hematopoiesis	J:10398
	gastrointestinal hemorrhage	J:10398
	increased leukocyte cell number	J:10398
	increased spleen red pulp amount	J:10398
	increased spleen weight	J:10398
	increased spleen white pulp amount	J:10398
	intermingled spleen red and white pulp	J:10398
	lethality at weaning, complete penetrance	J:10398
	lethargy	J:10398
	melena	J:10398
	narrow eye opening	J:10398
	pale kidney	J:10398
	pale liver	J:10398
	postnatal growth retardation	J:10398
	scaly skin	J:10398
	short perineum	J:10398
	small ears	J:10398
	small gonad	J:10398
	thrombocytopenia	J:10398
	tight skin	J:10398
Foxp3sf/0 involves: STOCK MR	delayed eyelid opening	J:13126
	postnatal lethality	J:13126
	scaly skin	J:13126
	tight skin	J:13126
Foxp3sf/Y involves: STOCK MR	abnormal male reproductive system morphology	J:13126
	absent prostate gland anterior lobe	J:14076
	absent scrotum	J:14076
	absent seminal vesicle	J:14076
	cryptorchism	J:14076
	decreased body size	J:13126
	delayed eyelid opening	J:13126
	male infertility	J:13126, J:14076
	postnatal lethality	J:13126
	premature death	J:13126
	scaly skin	J:13126, J:14076
	small gonad	J:14076
	small testis	J:14076
	tight skin	J:13126
Foxp3sf/? Not Specified	liver inflammation	J:138808
	lung inflammation	J:138808
Foxp3sf/Foxp3sf Tg(Rorc-EGFP)1Ebe/? involves: C57BL/6	abnormal effector T cell morphology	J:137020
Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori involves: C57BL/6	decreased regulatory T cell number	J:171378
	increased susceptibility to type IV hypersensitivity reaction	J:171378
Foxp3tm1(cre)Saka/Y involves: BALB/c	increased autoantibody level	J:140085
	stomach inflammation	J:140085
Foxp3tm1.1Ayr/Y involves: 129S1/Sv * 129X1/SvJ	abnormal CD4-positive, alpha beta T cell morphology	J:82560
	abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology	J:82560
	decreased body size	J:82560
	enlarged lymph nodes	J:82560
	enlarged spleen	J:82560
	increased susceptibility to autoimmune disorder	J:82560
	scaly ears	J:82560
	scaly skin	J:82560
	skin inflammation	J:82560
Foxp3tm1.1Ayr/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6	dermatitis	J:117743
	enlarged spleen	J:117743
	increased susceptibility to autoimmune disorder	J:117743
	liver inflammation	J:117743
	lung inflammation	J:117743
	lymph node inflammation	J:117743
	scaly skin	J:117743
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal T cell differentiation	J:125405
	decreased double-positive T cell number	J:125405
	dermatitis	J:117743
	enlarged spleen	J:117743
	increased susceptibility to autoimmune disorder	J:117743
	liver inflammation	J:117743
	lung inflammation	J:117743
	lymph node inflammation	J:117743
	scaly skin	J:117743
	thymus hypoplasia	J:125405
Foxp3tm1Ayr/Foxp3tm1Ayr involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:82560
Foxp3tm1Ayr/Foxp3tm1Ayr Foxn1tm3(cre)Nrm/Foxn1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal immune system phenotype	J:125405
Foxp3tm1Ayr/Foxp3tm1Ayr Tg(Cd4-cre)1Cwi/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal T cell differentiation	J:125405
	decreased double-positive T cell number	J:125405
	thymus hypoplasia	J:125405
Foxp3tm1Ayr/Y Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	decreased body size	J:97029
	dermatitis	J:97029
	enlarged lymph nodes	J:97029
	enlarged spleen	J:97029
	increased susceptibility to autoimmune disorder	J:97029
Foxp3tm1Flv/Foxp3+ involves: C57BL/6	no abnormal phenotype detected	J:97415
Foxp3tm1Tch/Y B6.129X1-Foxp3tm1Tch	abnormal inflammatory response	J:117165
	anemia	J:117165
	dermatitis	J:117165
	increased eosinophil cell number	J:117165
	increased IgE level	J:117165
	increased leukocyte cell number	J:117165
	increased lymphocyte cell number	J:117165
	increased monocyte cell number	J:117165
	postnatal lethality, complete penetrance	J:117165
	respiratory system inflammation	J:117165
	thrombocytopenia	J:117165
Foxp3tm1Tch/Foxp3+ C.129X1-Foxp3tm1Tch	no abnormal phenotype detected	J:117165
Foxp3tm1Tch/Y C.129X1-Foxp3tm1Tch	abnormal chemokine level	J:117165
	abnormal cytokine secretion	J:117165
	abnormal inflammatory response	J:117165
	abnormal lymphocyte physiology	J:117165
	abnormal respiratory mucosa goblet cell morphology	J:117165
	absent regulatory T cells	J:117165
	anemia	J:117165
	crypts of Lieberkuhn abscesses	J:117165
	dermatitis	J:117165
	enlarged spleen	J:117165
	increased activated T cell number	J:117165
	increased CD4-positive, alpha-beta T cell number	J:117165
	increased CD8-positive, alpha-beta T cell number	J:117165
	increased circulating interferon-gamma level	J:117165
	increased circulating interleukin-4 level	J:117165
	increased circulating interleukin-5 level	J:117165
	increased circulating interleukin-6 level	J:117165
	increased circulating interleukin-10 level	J:117165
	increased circulating tumor necrosis factor level	J:117165
	increased eosinophil cell number	J:117165
	increased IgE level	J:117165
	increased IgG1 level	J:117165
	increased leukocyte cell number	J:117165
	increased lymphocyte cell number	J:117165
	increased monocyte cell number	J:117165
	postnatal lethality, complete penetrance	J:117165, J:120636
	respiratory system inflammation	J:117165
	thrombocytopenia	J:117165
Foxp3tm2.1(EGFP/cre)Shori/Y involves: 129 * C57BL/6	decreased regulatory T cell number	J:234397
Foxp3tm2Ayr/Y involves: 129S1/Sv * 129X1/SvJ	normal immune system phenotype	J:97029
	no abnormal phenotype detected	J:97029
Foxp3tm2Ayr/Foxp3tm2Ayr involves: 129S1/Sv * 129X1/SvJ	normal immune system phenotype	J:97029
	no abnormal phenotype detected	J:97029
Foxp3tm2Flv/Foxp3+ involves: C57BL/6	no abnormal phenotype detected	J:118631
Foxp3tm2Flv/Y involves: C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:118631
	abnormal CD8-positive, alpha-beta T cell physiology	J:118631
	abnormal immune system physiology	J:118631
	blepharitis	J:118631
	decreased body size	J:118631
	enlarged lymph nodes	J:118631
	enlarged spleen	J:118631
	increased autoantibody level	J:118631
	male infertility	J:118631
	premature death	J:118631
	scaly skin	J:118631
Foxp3tm2Tch/Foxp3+ C.129X1-Foxp3tm2Tch	normal immune system phenotype	J:120713
Foxp3tm2Tch/Y C.129X1-Foxp3tm2Tch	normal immune system phenotype	J:120713
Foxp3tm3Tch/Y C.129X1-Foxp3tm3Tch	abnormal CD4-positive, alpha beta T cell morphology	J:120636
	abnormal CD4-positive, alpha-beta T cell physiology	J:120636
	abnormal cytokine secretion	J:120636
	abnormal immune system organ morphology	J:120636
	abnormal lymphocyte physiology	J:120636
	abnormal regulatory T cell physiology	J:120636
	abnormal T cell subpopulation ratio	J:120636
	colitis	J:120636
	enlarged lymph nodes	J:120636
	enlarged spleen	J:120636
	increased T cell proliferation	J:120636
	postnatal lethality, complete penetrance	J:120636
	thymus hypoplasia	J:120636
Foxp3tm3Tch/Foxp3+ C.129X1-Foxp3tm3Tch	abnormal CD4-positive, alpha-beta T cell physiology	J:120636
	decreased T cell number	J:120636
	decreased thymocyte number	J:120636
	increased T cell apoptosis	J:120636
	normal mortality/aging	J:120636
Foxp3tm5.2Ayr/Foxp3tm5.2Ayr involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	abnormal gut-associated lymphoid tissue morphology	J:156942
	abnormal intraepithelial T cell morphology	J:156942
	abnormal mesenteric lymph node morphology	J:156942
	abnormal Peyer's patch morphology	J:156942
	abnormal T cell differentiation	J:156942
	decreased regulatory T cell number	J:156942
	increased T cell number	J:156942
Foxp3tm6.2Ayr/Foxp3tm6.2Ayr involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	decreased regulatory T cell number	J:156942
Foxp3tm7.2Ayr/Foxp3+ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	decreased regulatory T cell number	J:156942
Foxp3tm7.2Ayr/Foxp3tm7.2Ayr involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	abnormal regulatory T cell morphology	J:156942
	decreased regulatory T cell number	J:156942
Foxp3tm8Ayr/Foxp3+ B6.129-Foxp3tm8Ayr	no abnormal phenotype detected	J:157377
Foxp3tm8Ayr/Y B6.129-Foxp3tm8Ayr	autoimmune response	J:157377
	premature death	J:157377