Foxp3^tm2Tch
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm2Tch
• Name: forkhead box P3; targeted mutation 2, Talal A Chatila
• MGI ID: MGI:3699400
• Synonyms: Foxp3^EGFP, FoxP3.GFP, Foxp3-GFP KI, Foxp3^IRES-GFP, Foxp3^tm2(EGFP)Tch
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm2Tch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120713
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An IRES-EGFP-SV40 poly A sequence was inserted immediately downstream of the endogenous Foxp3 translational stop codon, but upstream of the endogenous polyA signal, generating a bicistronic locus encoding both Foxp3 and EGFP. Expression of EGFP is restricted to the T cell lineage, primarily to the CD4+ T cell population. (J:120713)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 55 strains or lines available

References

• Original: J:120713 Haribhai D, et al., Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol. 2007 Mar 1;178(5):2961-72
• All: 214 reference(s)