Foxp3^tm2Flv
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm2Flv
• Name: forkhead box P3; targeted mutation 2, Richard A Flavell
• MGI ID: MGI:3700150
• Synonyms: FILIG
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm2Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118631
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette co-expressing luciferase and enhanced green fluorescent protein, under control of two tandem internal ribosomal entry sites, was inserted into the 3' UTR. (J:118631)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 55 strains or lines available

References

• Original: J:118631 Wan YY, et al., Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature. 2007 Feb 15;445(7129):766-70
• All: 4 reference(s)