Analysis Tools
normal phenotype
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• females are fertile and phenotypically normal
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Allele Symbol Allele Name Allele ID |
Foxp3tm2Flv targeted mutation 2, Richard A Flavell MGI:3700150 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females are fertile and phenotypically normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by ~3 months of age, all mice die of lymphoproliferative autoimmune syndrome
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• hemizygous mice are runted
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• at death, mice have enlarged spleens
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• at death, mice have enlarged spleens
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• infiltration of lymphocytes into non-lymphoid tissues is observed
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• mutants show high levels of activated CD4+ T cells
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• mutants show high levels of activated CD4+ T cells
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• serum levels are drastically elevated at death
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• nearly all males develop eyelid defects resembling blepharitis around 4 weeks of age
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• at death, mice have enlarged spleens
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• mutants show high levels of activated CD4+ T cells
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• mutants show high levels of activated CD4+ T cells
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• males are sterile (barren)
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• nearly all males develop eyelid defects resembling blepharitis around 4 weeks of age
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• >50% develop scaly skin
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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