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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lgr5
leucine rich repeat containing G protein coupled receptor 5
MGI:1341817
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apctm1Tno/Apctm1Tno
Elp3tm1.1Tac/Elp3tm1.1Tac
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac 		abnormal intestinal epithelium morphology J:227334
abnormal small intestinal crypt cell physiology J:227334
decreased tumor growth/size J:227334
Apctm1Tno/Apctm1Tno
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		increased intestinal adenoma incidence J:227334
Apctm2.1Cip/Apc+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		normal neoplasm J:186084
Bptfem1Zfa/Bptfem1Zfa
Ehfem1Zfa/Ehfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		abnormal digestive system development J:268724
abnormal response to radiation J:268724
Bptfem1Zfa/Bptfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		abnormal digestive system development J:268724
Cdc42tm1Brak/Cdc42tm1Brak
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal crypts of Lieberkuhn morphology J:184563
abnormal intestinal epithelium morphology J:184563
abnormal small intestinal villus morphology J:184563
absent Paneth cells J:184563
increased small intestinal crypt cell apoptosis J:184563
Cdc42tm1Brak/Cdc42tm1Brak
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		abnormal crypts of Lieberkuhn morphology J:184563
absent Paneth cells J:184563
Cdx2tm2Fbe/Cdx2tm2Fbe
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell migration J:179732
abnormal crypts of Lieberkuhn morphology J:179732
abnormal intestine physiology J:179732
abnormal Paneth cell physiology J:179732
increased Paneth cell number J:179732
Col1a1tm1(tetO-SOX2)Mjm/Col1a1+
Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J 		abnormal ileum crypts of Lieberkuhn morphology J:199754
abnormal intestine physiology J:199754
ectopic Paneth cells J:199754
increased cell proliferation J:199754
Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+
Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J 		abnormal intestine physiology J:199754
abnormal small intestine crypts of Lieberkuhn morphology J:199754
increased cell proliferation J:199754
Ctnnb1tm1Mmt/Ctnnb1+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129X1/SvJ 		intestine polyps J:193873
Elp3tm1.1Tac/Elp3tm1.1Tac
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac 		normal digestive/alimentary phenotype J:227334
Gata6osem1Zfa/Gata6osem1Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal enterocyte physiology J:268724
Gata6osem1Zfa/Gata6osem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		abnormal crypts of Lieberkuhn morphology J:268724
abnormal digestive system development J:268724
abnormal enterocyte physiology J:268724
abnormal response to radiation J:268724
abnormal small intestinal villus morphology J:268724
Gata6osem3Zfa/Gata6osem3Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal enterocyte proliferation J:268724
Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa
Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
involves: C57BL/6 		abnormal epidermal stem cell proliferation J:212415
abnormal hair follicle development J:212415
abnormal intestine development J:212415
abnormal intestine physiology J:212415
abnormal skin development J:212415
decreased hair follicle number J:212415
decreased kidney cell proliferation J:212415
perinatal lethality, complete penetrance J:212415
prenatal lethality, incomplete penetrance J:212415
normal renal/urinary system phenotype J:212415
thin epidermis J:212415
Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Cyp1a1-cre)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal small intestinal crypt cell proliferation J:174842
decreased small intestinal villus size J:174842
premature death J:174842
Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal intestine physiology J:174842
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Lrig1tm1.1(cre/ERT2)Rjc/Lrig1tm1.1(cre/ERT2)Rjc
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal crypts of Lieberkuhn morphology J:186084
increased intestinal adenoma incidence J:186084
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Mex3atm1.1(KOMP)Vlcg/Mex3a+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac 		abnormal intestinal epithelium morphology J:287423
abnormal small intestine crypts of Lieberkuhn morphology J:287423
postnatal lethality, incomplete penetrance J:287423
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Stk26tm2.1Zzh/Stk26tm2.1Zzh
involves: 129P2/OlaHsd * C57BL/6 		abnormal enterocyte proliferation J:322311
Lgr5tm1(cre/ERT2)Fjs/Lgr5tm2(Hbegf/EGFP)Fjs
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N 		normal digestive/alimentary phenotype J:177145
neonatal lethality, complete penetrance J:177145
Lgr5tm2(Hbegf/EGFP)Fjs/Lgr5+
involves: C57BL/6N 		normal digestive/alimentary phenotype J:177145
Nrbp1tm1.1Dja/Nrbp1tm1.2Dja
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J 		abnormal intestinal goblet cell morphology J:184685
abnormal intestine morphology J:184685
abnormal Paneth cell morphology J:184685
ectopic Paneth cells J:184685
Rab11atm1.1Ngao/Rab11atm1.1Ngao
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal intestinal epithelium morphology J:215917
Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd 		increased intestinal adenoma incidence J:186765
Rpap3tm1c(KOMP)Wtsi/Rpap3tm1c(KOMP)Wtsi
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6N 		no abnormal phenotype detected J:314346
Rprd1btm1Tshu/Rprd1btm1Tshu
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Tg(Vil1-cre)20Syr/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal digestive system development J:300857
Slc39a7tm1.1Tfk/Slc39a7tm1.1Tfk
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal intestine development J:236234
decreased Paneth cell number J:236234
normal digestive/alimentary phenotype J:236234
increased mortality induced by gamma-irradiation J:236234
TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Apctm1Tno/Apctm1Tno
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJae 		decreased susceptibility to induced morbidity/mortality J:198650
decreased tumor growth/size J:198650
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory