About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
91 phenotypes from 24 alleles in 23 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Lrp5em1Xjz/Lrp5em1Xjz
C57BL/6J-Lrp5em1Xjz 		abnormal retina development J:328283
decreased angiogenesis J:328283
Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
involves: 129S5/SvEvBrd 		abnormal retina vasculature morphology J:154863
blood vessel congestion J:154863
increased vascular permeability J:154863
Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal bone structure J:133196
abnormal long bone diaphysis morphology J:133196
abnormal lumbar vertebrae morphology J:133196
abnormal trabecular bone morphology J:133196
decreased body weight J:133196
decreased bone mass J:133196
decreased bone mineral density J:133196
decreased bone mineral density of femur J:133196
decreased bone ossification J:133196
decreased bone resorption J:133196
decreased compact bone mass J:133196
decreased trabecular bone mass J:133196
Lrp5m1Btlr/Lrp5+
C57BL/6J-Lrp5m1Btlr/Btlr 		decreased bone mineral density J:309727
Lrp5m1Btlr/Lrp5m1Btlr
C57BL/6J-Lrp5m1Btlr/Btlr 		decreased bone mass J:309727
decreased bone mineral density J:309727
fragile skeleton J:309727
Lrp5m2Btlr/Lrp5+
C57BL/6J-Lrp5m2Btlr/Btlr 		decreased bone mineral density J:309727
Lrp5m3Btlr/Lrp5m3Btlr
C57BL/6J-Lrp5m3Btlr/Btlr 		decreased bone mineral density J:309727
Lrp5m4Btlr/Lrp5m4Btlr
C57BL/6J-Lrp5m4Btlr/Btlr 		increased bone mineral density J:309727
Lrp5r18/Lrp5r18
C57BL/6J-Lrp5r18 		abnormal retina vasculature morphology J:135279
Lrp5tm1.1Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm1.1Mawa/Lrp5tm1.1Mawa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm1.1Vari/Lrp5tm1.1Vari
involves: 129S1/Sv 		no abnormal phenotype detected J:178499
Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		normal skeleton phenotype J:178499
Lrp5tm1.2Vari/Lrp5tm1.2Vari
involves: 129S1/Sv 		decreased bone mass J:178499
normal skeleton phenotype J:178499
Lrp5tm1Dgen/Lrp5tm1Dgen
B6.129P2-Lrp5tm1Dgen/J 		abnormal b-wave shape J:235600
abnormal retina blood vessel morphology J:235600
abnormal retina morphology J:235600
abnormal retina vasculature morphology J:235600
abnormal vascular plexus formation J:235600
abnormal vision J:235600
decreased total retina thickness J:235600
persistence of hyaloid vascular system J:169924, J:235600
Lrp5tm1Dgen/Lrp5tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		abnormal retina development J:328283
abnormal retina layer morphology J:101679
abnormal retina nerve fiber layer morphology J:101679
abnormal retina outer nuclear layer morphology J:101679
abnormal retina outer plexiform layer morphology J:101679
abnormal retina pigment epithelium morphology J:101679
decreased angiogenesis J:328283
decreased locomotor activity J:101679
disorganized retina inner nuclear layer J:101679
disorganized retina outer nuclear layer J:101679
disorganized retina outer plexiform layer J:101679
gliosis J:101679
hemorrhage J:328283
increased susceptibility to age-related retinal degeneration J:101679
increased thigmotaxis J:101679
retina fold J:101679
retina ganglion cell degeneration J:101679
retina photoreceptor degeneration J:101679
thin retina inner plexiform layer J:101679
thin retina outer nuclear layer J:101679
thin retina outer plexiform layer J:101679
Lrp5tm1Grw/Lrp5tm1Grw
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone structure J:104382
abnormal osteoblast physiology J:104382
abnormal trabecular bone morphology J:104382
decreased bone mass J:104382, J:213541
decreased bone mineral content J:213541
decreased bone mineral density J:104382, J:213541
decreased bone mineralization J:104382, J:213541
decreased bone ossification J:104382
decreased bone stiffness J:213541
decreased bone strength J:213541
decreased bone volume J:213541
decreased compact bone mass J:213541
decreased osteoblast cell number J:104382
decreased osteoclast cell number J:104382
decreased trabecular bone mass J:213541
osteoporosis J:213541
Lrp5tm1Jfh/Lrp5tm1Jfh
involves: 129S5/SvEvBrd * C57BL/6 		abnormal phalanx morphology J:91055
Lrp5tm1Jsak/Lrp5+
involves: C57BL/6 * CBA 		decreased circulating insulin level J:81174
impaired glucose tolerance J:81174
increased cholesterol level J:81174
Lrp5tm1Jsak/Lrp5tm1Jsak
involves: C57BL/6 * CBA 		abnormal calcium ion homeostasis J:81174
abnormal femur morphology J:81174
abnormal limb morphology J:81174
abnormal liver physiology J:81174
decreased circulating insulin level J:81174
decreased diameter of femur J:81174
decreased diameter of tibia J:81174
decreased insulin secretion J:81174
impaired glucose tolerance J:81174
increased cholesterol level J:81174
increased circulating VLDL cholesterol level J:81174
insulin resistance J:81174
thin parietal bone J:81174
Lrp5tm1Kry/Lrp5+
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal bone ossification J:75973
abnormal osteoblast physiology J:75973
decreased bone mass J:75973
decreased bone volume J:75973
delayed bone ossification J:75973
Lrp5tm1Kry/Lrp5+
involves: 129S1/Sv * 129X1/SvJ 		increased serotonin level J:146078
Lrp5tm1Kry/Lrp5tm1Kry
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal bone ossification J:75973
abnormal eye development J:75973
abnormal osteoblast physiology J:75973
abnormal trabecular bone morphology J:75973
decreased apoptosis J:75973
decreased bone mass J:75973
decreased bone volume J:75973
decreased osteoblast cell number J:75973
delayed bone ossification J:75973
persistence of hyaloid vascular system J:75973
postnatal lethality, incomplete penetrance J:75973
normal skeleton phenotype J:75973
Lrp5tm1Kry/Lrp5tm1Kry
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone mineralization J:216098
abnormal retina vasculature morphology J:135279, J:144980
decreased bone mass J:146078
decreased serotonin level J:146078
increased serotonin level J:146078
persistence of hyaloid vascular system J:101493, J:146078
normal skeleton phenotype J:146078
Lrp5tm1Lex/Lrp5+
involves: 129/Sv * C57BL/6J * FVB/N 		abnormal trabecular bone morphology J:111359
decreased bone mineral density J:111359
Lrp5tm1Lex/Lrp5tm1Lex
involves: 129/Sv * C57BL/6J * FVB/N 		decreased bone mineral density J:111359
persistence of hyaloid vascular system J:111359
Lrp5tm1Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ 		normal skeleton phenotype J:172746
Lrp5tm1Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		normal skeleton phenotype J:172746
Lrp5tm1Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		increased bone mass J:172746
Lrp5tm1Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N 		increased bone mass J:172746
Lrp5tm2.1Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm2.1Mawa/Lrp5tm2.1Mawa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm2Kry/Lrp5+
Tg(Vil1-cre)20Syr/0
involves: C57BL/6 * DBA/2 		decreased bone mass J:146078
decreased bone ossification J:146078
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Col1a1-cre)1Kry/0
involves: FVB 		normal homeostasis/metabolism phenotype J:146078
normal skeleton phenotype J:146078
normal vision/eye phenotype J:146078
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0
involves: C57BL/6 * DBA/2 		abnormal serotonin level J:146078
decreased bone mass J:146078
decreased bone ossification J:146078
decreased osteoblast cell number J:146078
decreased osteoblast proliferation J:146078
normal vision/eye phenotype J:146078
Lrp5tm2Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ 		normal skeleton phenotype J:172746
Lrp5tm2Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		normal skeleton phenotype J:172746
Lrp5tm2Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		increased bone mass J:172746
Lrp5tm2Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N 		increased bone mass J:172746
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Col1a1-cre)1Kry/0
involves: FVB 		normal homeostasis/metabolism phenotype J:146078
normal skeleton phenotype J:146078
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0
involves: C57BL/6 * DBA/2 		decreased serotonin level J:146078
increased bone mass J:146078
increased bone ossification J:146078
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Dmp1-cre)1Jqfe/0
involves: 129 * C57BL/6J * FVB/N 		decreased bone mass J:172746
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Vil1-cre)997Gum/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		normal skeleton phenotype J:172746
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
involves: 129S1/Sv 		abnormal bone trabecula morphology J:201597
decreased bone mass J:201597
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
involves: 129S1/Sv * C57BL/6J * FVB/N * SJL 		decreased bone mass J:172746
Lrp5tvrm111B/Lrp5tvrm111B
C57BL/6J-Lrp5tvrm111b/Pjn 		abnormal blood-retina barrier function J:241491
abnormal cone electrophysiology J:241491
abnormal retina neuronal layer morphology J:241491
abnormal retina vasculature morphology J:241491
decreased a-wave amplitude J:241491
decreased areal bone mineral density J:241491
decreased b-wave amplitude J:241491
decreased bone mineral content J:241491
persistence of hyaloid vascular system J:241491
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory