86 phenotypes from 17 alleles in 17 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Amhr2tm3(cre)Bhr/Amhr2+ Smad2tm1Cxd/Smad2tm1.1Mwst involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	normal reproductive system phenotype	J:142827
Smad2m1Mag/Smad2+ either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)	no abnormal phenotype detected	J:80520
Smad2m1Mag/Smad2m1Mag either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)	abnormal dorsal aorta morphology	J:80520
	abnormal embryonic tissue morphology	J:80520
	abnormal heart development	J:80520
	abnormal heart tube morphology	J:80520
	absent foregut	J:80520
	absent notochord	J:80520
	absent optic placodes	J:80520
	embryonic lethality, complete penetrance	J:80520
	failure of chorioallantoic fusion	J:80520
	rostral body truncation	J:80520
Smad2m1Mag/Smad2tm1Rob either: (involves: 129S/Sv * 129S/SvEv * Black Swiss) or (involves: 129S/Sv * 129S/SvEv * C57BL/6)	abnormal embryonic tissue morphology	J:80520
	embryonic lethality during organogenesis, complete penetrance	J:80520
Smad2tm1.1Epb/Smad2tm1.1Epb Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129/Sv * C57BL/6 * DBA * SJL	abnormal cell differentiation	J:119642
	abnormal cell migration	J:119642
	abnormal hepatocyte morphology	J:119642
	abnormal hepatocyte physiology	J:119642
	increased hepatocyte proliferation	J:119642
	normal liver/biliary system phenotype	J:119642
Smad2tm1.1Mwst/Smad2tm1.1Mwst involves: 129S6/SvEvTac * Black Swiss	no abnormal phenotype detected	J:94232
Smad2tm1.1Mwst/Smad2tm1.2Mwst involves: 129S6/SvEvTac * Black Swiss	no abnormal phenotype detected	J:94232
Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	abnormal cerebellar foliation	J:173787
	abnormal cerebellar granule cell migration	J:173787
	abnormal cerebellar granule cell morphology	J:173787
	abnormal cerebellum morphology	J:173787
	abnormal cerebellum vermis lobule IX morphology	J:173787
	abnormal cerebellum vermis lobule X morphology	J:173787
	abnormal gait	J:173787
	abnormal locomotor coordination	J:173787
	abnormal posture	J:173787
	abnormal Purkinje cell dendrite morphology	J:173787
	ataxia	J:173787
	decreased body size	J:173787
	decreased CNS synapse formation	J:173787
	impaired balance	J:173787
	increased neuron apoptosis	J:173787
	limb grasping	J:173787
	normal nervous system phenotype	J:173787
	premature death	J:173787
	short stride length	J:173787
	slow postnatal weight gain	J:173787
	tremors	J:173787
Smad2tm1.2Mwst/Smad2+ involves: 129S6/SvEvTac * Black Swiss	abnormal developmental patterning	J:94232
Smad2tm1.2Mwst/Smad2tm1.2Mwst involves: 129S6/SvEvTac * Black Swiss	decreased embryo size	J:94232
Smad2tm1Cxd/Smad2+ involves: 129S6/SvEvTac * C57BL/6	abnormal eye morphology	J:76396
	abnormal mandible morphology	J:76396
	abnormal Meckel's cartilage morphology	J:76396
Smad2tm1Cxd/Smad2tm1Cxd involves: 129S6/SvEvTac * NIH Black Swiss	abnormal developmental patterning	J:49084
	abnormal ectoplacental cone morphology	J:49084
	abnormal egg cylinder morphology	J:49084
	abnormal extraembryonic endoderm formation	J:49084
	abnormal extraembryonic tissue morphology	J:49084
	absent allantois	J:49084
	absent amnion	J:49084
	absent chorion	J:49084
	absent extraembryonic ectoderm	J:49084
	absent head fold	J:49084
	absent mesoderm	J:49084
	decreased embryo size	J:49084
	embryonic growth arrest	J:49084
	embryonic lethality between implantation and somite formation, complete penetrance	J:49084
	failure of primitive streak formation	J:49084
	failure to gastrulate	J:49084
Smad2tm1Cxd/Smad2tm1Mwst involves: 129S6/SvEvTac * Black Swiss	embryonic lethality, complete penetrance	J:94232
Smad2tm1Enl/Smad2+ involves: 129S4/SvJae	abnormal craniofacial morphology	J:48467
	abnormal embryonic tissue morphology	J:48467
	abnormal eye development	J:48467
	abnormal mandible morphology	J:48467
	abnormal primitive streak elongation	J:48467
	absent allantois	J:48467
	absent amnion	J:48467
	absent mandible	J:48467
	embryonic growth retardation	J:48467
	mandible hypoplasia	J:48467
Smad2tm1Enl/Smad2tm1Enl involves: 129S4/SvJae	abnormal developmental patterning	J:48467
	abnormal embryonic epiblast morphology	J:48467
	abnormal embryonic-extraembryonic boundary morphology	J:48467
	abnormal extraembryonic endoderm formation	J:48467
	abnormal extraembryonic tissue morphology	J:48467
	abnormal proamniotic cavity morphology	J:48467
	abnormal proximal-distal axis patterning	J:48467
	abnormal rostral-caudal axis patterning	J:48467
	abnormal visceral endoderm morphology	J:48467
	absent mesoderm	J:48467
	decreased embryo size	J:48467
	embryonic growth retardation	J:48467
	embryonic lethality, complete penetrance	J:48467
	failure of primitive streak formation	J:48467
Smad2tm1Kato/Smad2tm1Kato involves: 129S4/SvJae * C57BL/6J	abnormal developmental patterning	J:79668
	abnormal extraembryonic tissue morphology	J:79668
Smad2tm1Mwst/Smad2tm1.2Mwst involves: 129S6/SvEvTac * Black Swiss	abnormal developmental patterning	J:94232
	embryonic lethality during organogenesis, complete penetrance	J:94232
Smad2tm1Mwst/Smad2tm1Mwst involves: 129S6/SvEvTac * Black Swiss	no abnormal phenotype detected	J:94232
Smad2tm1Rak/Smad2tm1Rak involves: 129/Sv * C57BL/6J * SJL	abnormal embryonic tissue morphology	J:73507
	embryonic lethality between implantation and somite formation, complete penetrance	J:73507
Smad2tm1Rob/Smad2tm1Rob involves: 129S/SvEv	abnormal chorion morphology	J:46532
	abnormal embryonic epiblast morphology	J:46532
	abnormal embryonic tissue morphology	J:46532
	abnormal rostral-caudal axis patterning	J:46532
	absent ectoderm	J:46532
	absent endoderm	J:46532
	absent mesoderm	J:46532
	absent primitive node	J:46532
	embryonic lethality during organogenesis, complete penetrance	J:46532
	failure of primitive streak formation	J:46532
Smad2tm1Rob/Smad2tm2.1Rob involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1	abnormal embryonic tissue morphology	J:84300
	abnormal rostral-caudal axis patterning	J:84300
	embryonic lethality during organogenesis	J:84300
Smad2tm1Rob/Smad2tm2Rob Edil3Tg(Sox2-cre)1Amc/Edil3+ involves: 129S/SvEv * C57BL/6 * CBA * CD-1	abnormal anterior definitive endoderm morphology	J:84300
	abnormal heart looping	J:84300
	abnormal rostral-caudal axis patterning	J:84300
	absent forebrain	J:84300
	absent midbrain	J:84300
	enlarged pericardium	J:84300
	pericardial edema	J:84300
	truncated foregut	J:84300
Smad2tm1Xya/Smad2tm1Xya Tg(KRT5-cre)1Xya/0 involves: 129S6/SvEvTac	abnormal wound healing	J:178733
	enhanced wound healing	J:178733
	increased keratinocyte migration	J:178733
Smad2tm2.1Rob/Smad2tm2.1Rob involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1	abnormal embryonic tissue morphology	J:84300
	abnormal rostral-caudal axis patterning	J:84300
	embryonic lethality during organogenesis	J:84300
Smad2tm2Enl/Smad2+ involves: 129S4/SvJae	abnormal craniofacial morphology	J:48467
	abnormal embryonic tissue morphology	J:48467
	abnormal eye development	J:48467
	abnormal mandible morphology	J:48467
	embryonic growth retardation	J:48467
Smad2tm2Enl/Smad2tm2Enl involves: 129S4/SvJae	abnormal rostral-caudal axis patterning	J:48467
	embryonic growth retardation	J:48467
	embryonic lethality, complete penetrance	J:48467
Smad2tm2Kato/Smad2tm2Kato involves: 129S4/SvJae * C57BL/6J	abnormal developmental patterning	J:79668
	abnormal extraembryonic tissue morphology	J:79668
Smad2tm2Rob/Smad2tm2Rob involves: 129S/SvEv * C57BL/6	no abnormal phenotype detected	J:84300
Smad2tm3Rob/Smad2tm3Rob involves: 129S/SvEv * C57BL/6 * ICR	no abnormal phenotype detected	J:95374