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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcl11a
BCL11 transcription factor A
MGI:106190
37 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bcl11atm1.1Pwt/Bcl11atm1.1Pwt
Not Specified 		abnormal erythropoiesis J:151995
abnormal hemoglobin content J:151995
Bcl11atm1.1Sbri/Bcl11atm1.1Sbri
involves: BALB/cJ 		neonatal lethality, complete penetrance J:184011
Bcl11atm1Ngc/Bcl11a+
involves: 129S1/Sv 		abnormal common lymphocyte progenitor cell morphology J:194616
abnormal T cell differentiation J:194616
decreased DN2 thymocyte number J:194616
decreased hematopoietic stem cell number J:194616
decreased lymphocyte cell number J:207383
Bcl11atm1Ngc/Bcl11atm1Ngc
involves: 129S1/Sv * C57BL/6J 		abnormal dendritic cell differentiation J:207383
abnormal immunoglobulin heavy chain V(D)J recombination J:83646
absent B cells J:83646, J:207383
absent CD4-positive, alpha-beta T cells J:83646
absent lymphocyte J:207383
decreased plasmacytoid dendritic cell number J:207383
decreased T cell number J:83646
increased CD8-positive, alpha-beta T cell number J:83646
increased double-negative T cell number J:83646
increased gamma-delta T cell number J:83646
neonatal lethality, complete penetrance J:83646
small thymus J:83646
thymus hypoplasia J:83646
Bcl11atm1Peli/Bcl11atm1Peli
Not Specified 		normal hematopoietic system phenotype J:194616
Bcl11atm1Pwt/Bcl11atm1Pwt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		decreased B cell number J:207383
decreased circulating interferon-alpha level J:207383
decreased hematopoietic stem cell number J:207383
decreased plasmacytoid dendritic cell number J:207383
normal hematopoietic system phenotype J:207383
Bcl11atm1Pwt/Bcl11atm1Pwt
Eportm1.1(EGFP/icre)Uk/Epor+
involves: BALB/cJ 		normal hematopoietic system phenotype J:196140
Bcl11atm1Pwt/Bcl11atm1Pwt
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		decreased leukocyte cell number J:196140
normal hematopoietic system phenotype J:196140
Bcl11atm1Sbri/Bcl11atm1Sbri
Tg(PLAT-cre)116Sdu/0
Not Specified 		normal nervous system phenotype J:184011
Bcl11atm1Sbri/Bcl11atm1Sbri
Tg(Pou3f4-cre)32Cren/0
involves: CD-1 		abnormal axon morphology J:184011
abnormal excitatory postsynaptic currents J:184011
abnormal neurite morphology J:184011
abnormal neuron differentiation J:184011
abnormal sensory neuron innervation pattern J:184011
abnormal spinal cord dorsal horn morphology J:184011
Bcl11atm2.1Peli/Bcl11atm2.1Peli
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv 		abnormal common lymphocyte progenitor cell morphology J:194616
abnormal hematopoietic stem cell physiology J:194616
abnormal immune system morphology J:194616
abnormal T cell differentiation J:194616
decreased B cell number J:194616
decreased DN2 thymocyte number J:194616
decreased hematopoietic stem cell number J:194616
decreased immature B cell number J:194616
decreased pre-B cell number J:194616
decreased pro-B cell number J:194616
increased B cell apoptosis J:194616
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory