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Nrg1
Gene Detail
 Symbol
Name
ID
Nrg1
neuregulin 1
MGI:96083
Synonyms 6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF
Feature Type protein coding gene
Genetic Map
Chromosome 8
18.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:31818028-31918203 bp, - strand
From NCBI annotation of GRCm38

  100176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:8509  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: heregulin
Gene Tree: Nrg1
Alleles
and
phenotypes 		All alleles(12) : Targeted(11) Chemically induced(1)
 
Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.
 
Human Diseases Modeled Using Mouse Nrg1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications 		All GO classifications: (37 annotations)
Process cardiac conduction system development, cell migration, ...
Component axon, cytoplasm, ...
Function ErbB-2 class receptor binding, ErbB-3 class receptor binding, ...
External Resources: FuncBase
Expression Literature Summary: (71 records)
Data Summary: Results (535)    Tissues (212)    Images (83)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 481
In situ reporter (knock in) 38
RT-PCR 6
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(32) Genomic(2) cDNA(26) Primer pair(3) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000062991 (Evidence)
Entrez Gene211323 (Evidence)
DFCITC1587751, TC1589778, TC1618477, TC1631053
DoTSDT.101250768, DT.101270808, DT.103559932, DT.110885346, DT.91334987, DT.91361545, DT.91387806, DT.91393502
NIA Mouse Gene IndexU029697
Consensus CDS ProjectCCDS40315.1
International Mouse Knockout Project StatusNrg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 211323 NCBI Gene Model | MGI Sequence Detail 100176 C57BL/6J ±  kb
transcript NM_178591 RefSeq | MGI Sequence Detail 2103 C57BL/6 
polypeptide NP_848706 RefSeq | MGI Sequence Detail 700 C57BL/6 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(6)
Polymorphisms SNPs(279 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR018250 Neuregulin
InterPro IPR002154 Neuregulin 1-related, C-terminal
Protein Ontology PR:000029649 pro-neuregulin-1, membrane-bound isoform
References (Earliest) J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
(Latest) J:194919 Nam J, et al., Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013 Apr;140(7):1475-85
All references(171)
Other
accession IDs 		MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory