Nrg1^tm2Zhou
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm2Zhou
• Name: neuregulin 1; targeted mutation 2, Mingdong Zhou
• MGI ID: MGI:2448078
• Synonyms: Nrg1^tm
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm2Zhou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81106
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exon 11 and a portion of intron 11 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the transmembrane domain. (J:81106)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 53 strains or lines available

Notes

ES cell line = CJ1 (J:81106).

References

• Original: J:81106 Stefansson H, et al., Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002 Oct;71(4):877-92
• All: 35 reference(s)