All Phenotypes Nrg1<tm2Zhou> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nrg1^tm2Zhou
targeted mutation 2, Mingdong Zhou
MGI:2448078

Summary

2 genotypes

Allelic Composition	Nrg1^tm2Zhou/Nrg1^tm2Zhou
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1^tm2Zhou mutation (0 available); any Nrg1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• die at E10.5-E11.5

cardiovascular system

abnormal heart morphology ( J:81106 )

• cardiac defects observed

Allelic Composition	Nrg1^tm2Zhou/Nrg1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1^tm2Zhou mutation (0 available); any Nrg1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:81106 )

• animals are significantly more active than controls in an open field test and in a four arm-cross maze test

• treatment of mice with 1mg/kg clozapine reversed the phenotype

nervous system

abnormal prepulse inhibition ( J:81106 )

• impairment was seen, while normal acoustic startle response was also observed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:81106

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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