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Phenotypes Associated with This Genotype
Genotype
MGI:3530450
Allelic
Composition
Nrg1tm2Zhou/Nrg1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm2Zhou mutation (0 available); any Nrg1 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• animals are significantly more active than controls in an open field test and in a four arm-cross maze test
• treatment of mice with 1mg/kg clozapine reversed the phenotype

nervous system
• impairment was seen, while normal acoustic startle response was also observed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:81106


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory