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Gcgr
Gene Detail
 Symbol
Name
ID
Gcgr
glucagon receptor
MGI:99572
Synonyms GR
Feature Type protein coding gene
Genetic Map
Chromosome 11
84.24 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120530699-120538986 bp, + strand
From VEGA annotation of GRCm38

  8288 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Gcgr
Human
homologs
Human Homolog GCGR, glucagon receptor
NCBI Gene ID 2642
neXtProt AC  NX_P47871
Human Synonyms  GGR
Human Chr (Location)  17q25; chr17:79762010-79771889 (+)  GRCh37.p10
Disease Associations  (1) Diseases Associated with Human GCGR
Alleles
and
phenotypes 		All alleles(4) : Targeted(4)
 
Animals homozygous for a targeted mutation in this gene exhibit somewhat reduced blood glucose levels and increased plasma glucagon levels.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (22 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component endosome, integral to membrane, ...
Function glucagon receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Results (130)    Tissues (24)    Images (52)
Theiler Stages: 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 54
Northern blot 31
RT-PCR 45
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(29) Genomic(1) cDNA(26) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000004269 (Evidence)
Ensembl Gene ModelENSMUSG00000025127 (Evidence)
Entrez Gene14527 (Evidence)
UniGene22329
DFCITC1583574, TC1616227
DoTSDT.101362834, DT.91337494, DT.94304436
NIA Mouse Gene IndexU013665
Consensus CDS ProjectCCDS25739.1
International Mouse Knockout Project StatusGcgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004269 VEGA Gene Model | MGI Sequence Detail 8288 C57BL/6J ±  kb
transcript OTTMUST00000009673 VEGA | MGI Sequence Detail 1957 Not Applicable 
polypeptide OTTMUSP00000004661 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms SNPs(14 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
InterPro IPR003291 GPCR, family 2, glucagon receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000007892 glucagon receptor
References (Earliest) J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
(Latest) J:194789 Mu J, et al., Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist. PLoS One. 2012;7(11):e49572
All references(62)
Other
accession IDs 		MGD-MRK-16353
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory